Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BID_HUMAN
Description:BH3 interacting domain death agonist [Source:HGNC Symbol;Acc:1050]
Location:chr22 q11.21
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T59YDELQtDGNRSCK2a1-rsRegPhos
T59YDELQtDGNRSCSNK2A2HPRD
S64TDGNRsSHSRLCSNK1A1HPRD
S64TDGNRsSHSRLCSNK2A1HPRD
T59YDELQtDGNRSCSNK2A1HPRD
S64TDGNRsSHSRLP67870(Casein kinase II )RegPhos
S64TDGNRsSHSRLCK2a2RegPhos
S64TDGNRsSHSRLCSNK2A2HPRD
Y100PQWEGyDELQTHPRD
S78EADSEsQEDIIBIDPhosphoSitePlus
S64TDGNRsSHSRLCK1aRegPhos
S64TDGNRsSHSRLCK1_groupphosphoELM; RegPhos
T59YDELQtDGNRSCK1_groupphosphoELM; RegPhos
T59YDELQtDGNRSCK1aRegPhos
T59YDELQtDGNRSCK1eRegPhos
Y54PQWEGyDELQTHPRD; phosphoELM; RegPhos
T59YDELQtDGNRSCSNK2BHPRD
T59YDELQtDGNRSCSNK1A1HPRD
T59YDELQtDGNRSCK2a2RegPhos
S78EADSEsQEDIIHPRD; phosphoELM; RegPhos
T59YDELQtDGNRSCSNK1EHPRD
S64TDGNRsSHSRLCK1eRegPhos
T59YDELQtDGNRSBIDPhosphoSitePlus
T59YDELQtDGNRSP67870(Casein kinase II )RegPhos
S124EADSEsQEDIIHPRD
S64TDGNRsSHSRLCK2a1RegPhos
Y54PQWEGyDELQTBIDPhosphoSitePlus
T59YDELQtDGNRSCK2_groupphosphoELM; RegPhos
T59YDELQtDGNRSCK2a1RegPhos
S64TDGNRsSHSRLCK2a1-rsRegPhos
S64TDGNRsSHSRLCSNK2BHPRD
S64TDGNRsSHSRLCK2_groupphosphoELM; RegPhos
S64TDGNRsSHSRLCSNK1EHPRD

Dephosphorylation site
BID_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318822S110TCOSMICOvarian Cancer21720365
ENSP00000318822*242SCOSMICBreast Cancer16959974

Differential expressed protein
BID_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BID_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1A_HUMANBID_HUMANkinase -> substrateHPRD
ZAGL2_HUMANBID_HUMANkinase -> substrateRegPhos
CSK2B_HUMANBID_HUMANkinase -> substrateHPRD
CSK22_HUMANBID_HUMANkinase -> substrateHPRD
KC1E_HUMANBID_HUMANkinase -> substrateHPRD
CSK21_HUMANBID_HUMANkinase -> substrateHPRD
CASP8_HUMANBID_HUMANotherNetPath
CASP8_HUMANBID_HUMANotherKEGG
BID_HUMANCYC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05152Tuberculosis
hsa04210Apoptosis
hsa04115p53 signaling pathway
hsa05416Viral myocarditis
hsa05010Alzheimer's disease
hsa05200Pathways in cancer
hsa05014Amyotrophic lateral sclerosis (ALS)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032464positive regulation of protein homooligomerizationIDAbiological_process
GO:0016020membraneTAScellular_component
GO:0006915apoptotic processTASbiological_process
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0001836release of cytochrome c from mitochondriaIEAbiological_process
GO:0005741mitochondrial outer membraneTAScellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0008637apoptotic mitochondrial changesTASbiological_process
GO:2001238positive regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0008637apoptotic mitochondrial changesIEAbiological_process
GO:2000045regulation of G1/S transition of mitotic cell cyclIEAbiological_process
GO:0001836release of cytochrome c from mitochondriaIDAbiological_process
GO:0005739mitochondrionTAScellular_component
GO:0051402neuron apoptotic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005123death receptor bindingTASmolecular_function
GO:0032592integral to mitochondrial membraneIEAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0032461positive regulation of protein oligomerizationIDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0034349glial cell apoptotic processIEAbiological_process
GO:0090150establishment of protein localization to membraneIDAbiological_process
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0007420brain developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0090200positive regulation of release of cytochrome c froIMPbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0008625extrinsic apoptotic signaling pathway via death doTASbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0006626protein targeting to mitochondrionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046902regulation of mitochondrial membrane permeabilityIEAbiological_process


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