Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPTB2_HUMAN
Description:spectrin, beta, non-erythrocytic 1 [Source:HGNC Symbol;Acc:11275]
Location:chr2 p16.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S825VRGRLsGIEERHPRD
S817QEHAEsPDVRGHPRD
S2316HEVSAsTQSTPPhosphoSitePlus; HPRD
S825VRGRLsGIEERSpectrinPhosphoSitePlus
S1076LDDFQsWLSRTHPRD
T2107SPEPStKVSEEPhosphoSitePlus; HPRD
S2110PSTKVsEEAESCSNK2A1HPRD
S804QEHAEsPDVRGHPRD
T2317EVSAStQSTPAPhosphoSitePlus; HPRD
T2159ATEQRtSSKESPhosphoSitePlus; phosphoELM
Y381NNQKVyMPREGSpectrinPhosphoSitePlus
S2110PSTKVsEEAESCK2a1-rsRegPhos
Y1303AQDMSyDEARNHPRD
S553KVLVLsQDYGKHPRD
Y2249ASGIPyHSEVPPHPhosphoSitePlus
S2148ETVDTsEMVNGPhosphoSitePlus; HPRD; phosphoELM
Y1171SQSHAyQQFLRSpectrinPhosphoSitePlus
Y1811ELHKFyHDAKESpectrinPhosphoSitePlus
S2341ITSESsPGKREPhosphoSitePlus; HPRD; phosphoELM
T2195ARTQEtPSAQMPhosphoSitePlus; RegPhos
Y796EEIANyRPTLDHPRD
S2106PSPEPsTKVSEHPRD
S1057KNREAsLGEASHPRD
T2328SSRAQtLPTSVPhosphoSitePlus; HPRD; phosphoELM
Y796EEIANyRPTLDSpectrinPhosphoSitePlus
S10RTSSIsGPLSPHPRD
S2324STPASsRAQTLPhosphoSitePlus; HPRD
T2155MVNGAtEQRTSPhosphoSitePlus; HPRD; phosphoELM
T2320ASTQStPASSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T779HDEYStQSLVKSpectrinPhosphoSitePlus
T333LQAFNtYRTVEHPRD
Y79RITDLyTDLRDCHPhosphoSitePlus
S770KIVSSsDVGHDSpectrinPhosphoSitePlus
T6SISGHPRD
S2097PSTKVsEEAESHPRD
S2128KGEQVsQNGLPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1996KLLQLtEKRKESpectrinPhosphoSitePlus
S150QIQDIsVETEDHPRD
S2115KGEQVsQNGLPHPRD
S96LLEVLsGERLPCHPhosphoSitePlus
T1217EDFMTtMDANESpectrinPhosphoSitePlus
S1044KNREAsLGEASHPRD
S2358KEKRFsLFGKKPhosphoSitePlus
T2335PTSVVtITSESHPRD; phosphoELM
S781EYSTQsLVKKHSpectrinPhosphoSitePlus
Y2268EVALDyKKKKHPHPhosphoSitePlus
T1217EDFMTtMDANEHPRD
T999LQRKLtGMERDRegPhos
S1918KFRFFsMVRDLRegPhos
Y1303AQDMSyDEARNSpectrinPhosphoSitePlus
S812VRGRLsGIEERHPRD
S2165SSKESsPIPSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S2093PSPEPsTKVSEHPRD
S1804QILAAsYELHKPhosphoSitePlus
T2094SPEPStKVSEEHPRD
S2102KRRPPsPEPSTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S163QIQDIsVETEDPhosphoSitePlus; HPRD
Y777VGHDEySTQSLSpectrinPhosphoSitePlus
T838EVAELtRLRKQSpectrinPhosphoSitePlus
S228DKLKKsNAHYNCHPhosphoSitePlus
T1203QEDFMtTMDANHPRD
S333RKFANsLVGVQSpectrinPhosphoSitePlus
S795LHEQAsALPQEHPRD
Y2039LGQEPyLSSRESpectrinPhosphoSitePlus
T2331AQTLPtSVVTIHPRD
T2187AQSAAtLPARTPhosphoSitePlus; HPRD; phosphoELM
T2159ATEQRtSSKESCSNK2A1HPRD
Y17PLSPAyTGQVPHPRD
T999LQRKLtGMERDSpectrinPhosphoSitePlus
T2147AETVDtSEMVNHPRD; phosphoELM
S1985RKHYAsEEIKESpectrinPhosphoSitePlus
Y1983LARKHyASEEISpectrinPhosphoSitePlus
S2251GIPYHsEVPVSPHPhosphoSitePlus
S2110PSTKVsEEAESCK2a1RegPhos
Y1805ILAASyELHKFSpectrinPhosphoSitePlus
S2110PSTKVsEEAESPhosphoSitePlus
Y1680KVDKLyAGLKDSpectrinPhosphoSitePlus
S2221KASSRsWHNVYPHPhosphoSitePlus
Y274YVVTYyHYFSKCHPhosphoSitePlus
S540KVLVLsQDYGKHPRD
S1057KNREAsLGEASSpectrinPhosphoSitePlus
S2089KRRPPsPEPSTHPRD
Y1124QTDAQyMFLRQHPRD
Y1805ILAASyELHKFRegPhos
S2338VVTITsESSPGPhosphoSitePlus; HPRD
S2160TEQRTsSKESSPhosphoSitePlus; HPRD; phosphoELM
T2159ATEQRtSSKESPRKACAHPRD
Y1137QTDAQyMFLRQHPRD
Y1644QAVEDyAETVHSpectrinPhosphoSitePlus
Y1730ELGQDyEHVTMSpectrinPhosphoSitePlus
S2041QEPYLsSREIGSpectrinPhosphoSitePlus
S2172IPSPTsDRKAKPhosphoSitePlus; HPRD; phosphoELM
S2169SSPIPsPTSDRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1114NEIDNyEEDYQSpectrinPhosphoSitePlus
T2337SVVTItSESSPPhosphoSitePlus; HPRD
S14ISGPLsPAYTGHPRD
S1243DGNINsDRIQESpectrinPhosphoSitePlus
T2159ATEQRtSSKESPKACaRegPhos
Y1290AQDMSyDEARNHPRD
Y783EEIANyRPTLDHPRD
S2125PAEQGsPRVSYHPRD
Y1118NYEEDyQKMRDSpectrinPhosphoSitePlus
Y493LEAENyHDIKRSpectrinPhosphoSitePlus
T2297DEEMNtWIQAIPHPhosphoSitePlus
S1388ELFTQsCADLDSpectrinPhosphoSitePlus
S2115SEEAEsQQQWDPhosphoSitePlus; RegPhos
Y831GIEERyKEVAESpectrinPhosphoSitePlus
T1216QEDFMtTMDANHPRD
Y620HMEFCyQELCQSpectrinPhosphoSitePlus
S215DKLKKsNAHYNHPRD
T2159ATEQRtSSKESCK2a1RegPhos
S7ISGPHPRD
S1168NLLSQsHAYQQPhosphoSitePlus
S2314DKHEVsASTQSPhosphoSitePlus
T2159ATEQRtSSKESCK2a1-rsRegPhos
S228DKLKKsNAHYNHPRD
T2171PIPSPtSDRKAPhosphoSitePlus; HPRD; phosphoELM
S2340TITSEsSPGKRPhosphoSitePlus; HPRD; phosphoELM
S2164TSSKEsSPIPSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T2080ALERLtTLELLSpectrinPhosphoSitePlus
S1447QAQALsQEGKSSpectrinPhosphoSitePlus
S2161EQRTSsKESSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1204EDFMTtMDANEHPRD
T1734DYEHVtMLQERSpectrinPhosphoSitePlus
T346LQAFNtYRTVEHPRD; RegPhos
S2138PAEQGsPRMAEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S808LHEQAsALPQEHPRD
S278YYHYFsKMKALCHPhosphoSitePlus
S817QEHAEsPDVRGSpectrinPhosphoSitePlus
T1216QEDFMtTMDANSpectrinPhosphoSitePlus
S8LQRTSsISGPLHPRD
S1063LDDFQsWLSRTHPRD
S2319SASTQsTPASSPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
SPTB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000349259L962FTCGAOvarian Cancer21720365, 18772890
ENSP00000349259I1636MCOSMICOvarian Cancer20826764
ENSP00000349259L1314*COSMICOvarian Cancer21720365
ENSP00000349259M526ICOSMICSkin Cancer21984974
ENSP00000349259V789MCOSMICHead and Neck Cancer21798893
ENSP00000349259R107*COSMICBreast Cancer17932254
ENSP00000349259R681WBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000334156A447TBIOMARTBreast Cancer21930507, 21930502
ENSP00000349259L1314*TCGAOvarian Cancer21720365, 18772890
ENSP00000349259L962FCOSMICOvarian Cancer21720365
ENSP00000349259R523QCOSMICHead and Neck Cancer21798893
ENSP00000349259A460TBIOMARTBreast Cancer21930507, 21930502
ENSP00000349259R972QCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000349259hepatitis C virusNormal vs. CancertissueDown0.418715028
ENSP00000349259Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.4216319398
ENSP00000349259Hepatocellular CarcinomaMetastasiscell lineUp1.819016532
ENSP00000349259Breast CancerNormal vs. CancertissueDown20560667
ENSP00000349259Breast CancerNormal vs. CancertissueDown0.5420739354
ENSP00000349259Gastric CancerNormal vs. CancertissueDown0.4515761955

Hyperphosphorylation site
SPTB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANSPTB2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANSPTB2_HUMANkinase -> substrateRegPhos
KPCA_HUMANSPTB2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
SPTB2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIDAcellular_component
GO:0007009plasma membrane organizationIMPbiological_process
GO:0030673axolemmaISScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0031430M bandIEAcellular_component
GO:0030506ankyrin bindingIPImolecular_function
GO:0007182common-partner SMAD protein phosphorylationIEAbiological_process
GO:0000281cytokinesis after mitosisIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0030863cortical cytoskeletonIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0003779actin bindingIEAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0072661protein targeting to plasma membraneIMPbiological_process
GO:0007184SMAD protein import into nucleusIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0014731spectrin-associated cytoskeletonNAScellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0032437cuticular plateIEAcellular_component
GO:0008091spectrinIEAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005200structural constituent of cytoskeletonIMPmolecular_function
GO:0072661protein targeting to plasma membraneIEAbiological_process
GO:0043001Golgi to plasma membrane protein transportIMPbiological_process
GO:0051693actin filament cappingIEAbiological_process
GO:0071709membrane assemblyIMPbiological_process


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