Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VCAM1_HUMAN
Description:vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:12663]
Location:chr1 p21.2
Node attribute:PPI(target); PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S706VLYFAsSLIIPTMPhosphoSitePlus
Y703ELLVLyFASSLTMPhosphoSitePlus
Y718IGMIIyFARKATMPhosphoSitePlus
S707LYFASsLIIPATMPhosphoSitePlus
Y653SIDGAyTIRKAV-setPhosphoSitePlus

Dephosphorylation site
VCAM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000294728G395RCOSMICCentral Nervous System Neoplasms18772396
ENSP00000294728V516IBIOMARTBrain Cancer21930507, 21930502
ENSP00000294728S622FCOSMICSkin Cancer21984974
ENSP00000294728G293RCOSMICSkin Cancer21984974
ENSP00000294728P254LCOSMICHead and Neck Cancer21798893

Differential expressed protein
VCAM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VCAM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANVCAM1_HUMANkinase -> substrateRegPhos
KS6A1_HUMANVCAM1_HUMANkinase -> substrateHPRD; RegPhos
KS6A2_HUMANVCAM1_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANVCAM1_HUMANkinase -> substrateHPRD
VCAM1_HUMANVCAM1_HUMANotherKEGG
TF65_HUMANVCAM1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05143African trypanosomiasis
hsa04064NF-kappa B signaling pathway
hsa04670Leukocyte transendothelial migration
hsa05144Malaria
hsa04514Cell adhesion molecules (CAMs)
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060710chorio-allantoic fusionIEAbiological_process
GO:0007157heterophilic cell-cell adhesionIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0001666response to hypoxiaIEAbiological_process
GO:0002526acute inflammatory responseIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0045177apical part of cellIDAcellular_component
GO:0005178integrin bindingIEAmolecular_function
GO:0007584response to nutrientIEAbiological_process
GO:0030175filopodiumIDAcellular_component
GO:0007159leukocyte cell-cell adhesionIEAbiological_process
GO:0060669embryonic placenta morphogenesisIEAbiological_process
GO:0002544chronic inflammatory responseIEAbiological_process
GO:0050901leukocyte tethering or rollingIEPbiological_process
GO:0010212response to ionizing radiationIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0071065alpha9-beta1 integrin-vascular cell adhesion molecIDAcellular_component
GO:0030183B cell differentiationICbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0050839cell adhesion molecule bindingIPImolecular_function
GO:0071944cell peripheryIEAcellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0007157heterophilic cell-cell adhesionIEAbiological_process
GO:0042383sarcolemmaIEAcellular_component
GO:0022614membrane to membrane dockingIEPbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007568agingIEAbiological_process
GO:0007159leukocyte cell-cell adhesionIDAbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0042102positive regulation of T cell proliferationIDAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0002102podosomeIDAcellular_component
GO:0005178integrin bindingIDAmolecular_function
GO:0050776regulation of immune responseTASbiological_process
GO:0071333cellular response to glucose stimulusIEAbiological_process
GO:0007155cell adhesionIDAbiological_process
GO:0005902microvillusIDAcellular_component


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