Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MPIP2_HUMAN
Description:cell division cycle 25B [Source:HGNC Symbol;Acc:1726]
Location:chr20 p13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S160RLLGHsPVLRNCDK1HPRD; phosphoELM; SysPTM
S280QRLFRsPSMPCMELKHPRD
S353NKRRRsVTPPEAurora AphosphoELM; SysPTM
S160RLLGHsPVLRNCDC2(CDK1RegPhos; SysPTM
T341RRRSVtPPEEQHPRD
S323LFRSPsMPCSVM-inducer_phospPhosphoSitePlus; SysPTM
S321QRLFRsPSMPCMELKHPRD; RegPhos
S89RLTHLsLSRRAPhosphoSitePlus
S323LFRSPsMPCSVEg3 kinasephosphoELM; SysPTM
S375VLRSKsLCHDEM-inducer_phospPhosphoSitePlus; SysPTM
S186GSGAAsSSGEDM-inducer_phospPhosphoSitePlus
S97RRASEsSLSSEPhosphoSitePlus
S186GSGAAsSSGEDCK2_groupphosphoELM; RegPhos
S151IRRFQsMPVRLM-inducer_phospPhosphoSitePlus; SysPTM
S312NKRRRsVTPPEAURKAHPRD
T56PVTTLtQTMHDPhosphoSitePlus
S209KPTHPsSTHALM-inducer_phospPhosphoSitePlus
T54SSPVTtLTQTMPhosphoSitePlus
S375VLRSKsLCHDEHPRD; phosphoELM; SysPTM
S42HGLLGsPVRAAPhosphoSitePlus; SysPTM
S187SGAASsSGEDKCK2_groupphosphoELM; RegPhos
S339NKRRRsVTPPEAURKAHPRD
S249EVEELsPLALGphosphoELM; SysPTM
S186GSGAAsSSGEDCK2a1RegPhos
T127HMAEQtFEQAIM-inducer_phospPhosphoSitePlus
S187SGAASsSGEDKCK2a1-rsRegPhos
S307QRLFRsPSMPCMELKHPRD
S321QRLFRsPSMPCM-inducer_phospPhosphoSitePlus
S169RNITNsQAPDGM-inducer_phospPhosphoSitePlus; SysPTM
S230AQRPSsAPDLMM-inducer_phospPhosphoSitePlus
S465ERDAEsFLLKSRhodanesePhosphoSitePlus; SysPTM
S513VNDYPsLYYPERhodanesePhosphoSitePlus
S172GSGAAsSSGEDCSNK2A1HPRD
S160RLLGHsPVLRNCDC2RegPhos; SysPTM
S187SGAASsSGEDKCSNK2A1HPRD
S230AQRPSsAPDLMCHK1phosphoELM
T167VLRNItNSQAPM-inducer_phospPhosphoSitePlus; SysPTM
S187SGAASsSGEDKCK2_alphaphosphoELM
T556KDELKtFRLKTPhosphoSitePlus
S375VLRSKsLCHDEBRSK1phosphoELM; RegPhos; SysPTM
S186GSGAAsSSGEDCK2_alphaphosphoELM
S353NKRRRsVTPPEAURKAHPRD; SysPTM
S50RAAASsPVTTLPhosphoSitePlus; SysPTM
S249EVEELsPLALGM-inducer_phospPhosphoSitePlus; SysPTM
S187SGAASsSGEDKCK2a1RegPhos
T53ASSPVtTLTQTPhosphoSitePlus
T265PAEGDtEEDDGM-inducer_phospPhosphoSitePlus
S563RLKTRsWAGERPhosphoSitePlus; SysPTM
T58TTLTQtMHDLAPhosphoSitePlus
T314RRRSVtPPEEQHPRD
Y312KDLVMySKCQRM-inducer_phospPhosphoSitePlus
S353NKRRRsVTPPEM-inducer_phospPhosphoSitePlus; SysPTM
S146RLLGHsPVLRNCDK1HPRD
T404AFLLQtVDGKHPhosphoSitePlus; SysPTM
S173SGAASsSGEDKCSNK2A1HPRD
S186GSGAAsSSGEDCK2a1-rsRegPhos
S334VLRSKsLCHDEHPRD
S187SGAASsSGEDKCK2a1(CK2 alphaRegPhos
S397LIGDYsKAFLLPhosphoSitePlus
S353NKRRRsVTPPEAurARegPhos; SysPTM
S169RNITNsQAPDGEg3 kinasephosphoELM; SysPTM
T355RRRSVtPPEEQM-inducer_phospPhosphoSitePlus; SysPTM
S187SGAASsSGEDKM-inducer_phospPhosphoSitePlus
S160RLLGHsPVLRNM-inducer_phospPhosphoSitePlus; SysPTM
S353NKRRRsVTPPEphosphoELM; SysPTM
S178DGRRKsEAGSGM-inducer_phospPhosphoSitePlus; SysPTM
S238DLMCLsPDRKMM-inducer_phospPhosphoSitePlus
S361VLRSKsLCHDEHPRD
S291PPGMEsLISAPM-inducer_phospPhosphoSitePlus
S353NKRRRsVTPPEMELK(pEg3 kinaseRegPhos; SysPTM
T355RRRSVtPPEEQHPRD; phosphoELM; SysPTM
S186GSGAAsSSGEDCSNK2A1HPRD
S323LFRSPsMPCSVMAPKAPK2phosphoELM; RegPhos; SysPTM
S169RNITNsQAPDGMELK(pEg3 kinaseRegPhos; SysPTM
S182KSEAGsGAASSM-inducer_phospPhosphoSitePlus
S186GSGAAsSSGEDCK2a1(CK2 alphaRegPhos
T344LERPQDRDTPVQNK SysPTM 2.0
S470DAESFLLKSPIAPCSLDK SysPTM 2.0
T344LERPQDRDTPVQNK SysPTM 2.0
S470DAESFLLKSPIAPCSLDK SysPTM 2.0

Dephosphorylation site
MPIP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339170R179CBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000245960Uterine CancerNormal vs. Cancercell lineDown0.1715838902
ENSP00000245960Uterine CancerNormal vs. Cancercell lineUp2.115838902

Hyperphosphorylation site
MPIP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BRSK1_HUMANMPIP2_HUMANkinase -> substrateRegPhos
MK14_HUMANMPIP2_HUMANkinase -> substrateKEGG
CSK21_HUMANMPIP2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CDK1_HUMANMPIP2_HUMANkinase -> substrateHPRD; RegPhos
AURKA_HUMANMPIP2_HUMANkinase -> substrateHPRD
MAPK2_HUMANMPIP2_HUMANkinase -> substrateRegPhos
MELK_HUMANMPIP2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04110Cell cycle
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001556oocyte maturationIEAbiological_process
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0005813centrosomeIDAcellular_component
GO:0004725protein tyrosine phosphatase activityTASmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0000087M phase of mitotic cell cycleIEAbiological_process
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0051301cell divisionIEAbiological_process
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0007144female meiosis IIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006470protein dephosphorylationIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000922spindle poleIDAcellular_component
GO:0007067mitosisIEAbiological_process
GO:0005622intracellularNAScellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0035335peptidyl-tyrosine dephosphorylationTASbiological_process


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