Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRF_HUMAN
Description:serum response factor (c-fos serum response element-binding transcription factor) [Source:HGNC Symbol;Acc:11291]
Location:chr6 p21.1
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S103LKRSLsEMEIGRSK3RegPhos
S103LKRSLsEMEIGCAMK2AHPRD
S83GSEGDsESGEEPhosphoSitePlus; phosphoELM; RegPhos
S79ALYSGsEGDSECK2_alphaphosphoELM
S224LNSPDsPPRSDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S103LKRSLsEMEIGRSK_groupphosphoELM; RegPhos
S446MQVSHsQVQEPDNAPKRegPhos
S251LTYQVsESDSSPhosphoSitePlus
S176KAYELsTLTGTSRF-TFPhosphoSitePlus
S103LKRSLsEMEIGCaMK2aRegPhos
S435VLNAFsQAPSTDNA-PKphosphoELM
S83GSEGDsESGEECSNK2A1HPRD
S77AGALYsGSEGDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T159KLRRYtTFSKRPKC_alphaphosphoELM
T4__MLPtQAGAAPhosphoSitePlus
T199VYTFAtRKLQPSRF-TFPhosphoSitePlus
S162RYTTFsKRKTGSRF-TFPhosphoSitePlus
S83GSEGDsESGEECK2a1(CK2 alphaRegPhos
S103LKRSLsEMEIGMAPKAPK2HPRD; RegPhos
T177AYELStLTGTQSRF-TFPhosphoSitePlus
S79ALYSGsEGDSECK2a1(CK2 alphaRegPhos
T160LRRYTtFSKRKCAMK2AHPRD
S103LKRSLsEMEIGPhosphoSitePlus; RegPhos
S103LKRSLsEMEIGRPS6KA1HPRD
S435VLNAFsQAPSTDNAPKRegPhos
S228DSPPRsDPTTDHPRD; phosphoELM
S79ALYSGsEGDSEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S83GSEGDsESGEECK2a1RegPhos
S253YQVSEsDSSGEPhosphoSitePlus; RegPhos
S446MQVSHsQVQEPPRKDCHPRD
S85EGDSEsGEEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S85EGDSEsGEEEEMAPKAPK2phosphoELM; RegPhos
S83GSEGDsESGEECK2_alphaphosphoELM
T71TTPAPtAGALYHPRD
S77AGALYsGSEGDCK2_alphaphosphoELM
Y76TAGALySGSEGHPRD; RegPhos
T27LNRTPtGRPGGPhosphoSitePlus
S101RGLKRsLSEMEPhosphoSitePlus
S83GSEGDsESGEECK2a1-rsRegPhos
T159KLRRYtTFSKRSRF-TFPhosphoSitePlus
S435VLNAFsQAPSTPhosphoSitePlus
S446MQVSHsQVQEPPhosphoSitePlus
S446MQVSHsQVQEPDNA-PKphosphoELM
T160LRRYTtFSKRKCaMK2aRegPhos
S16ALGRGsALGGSPhosphoSitePlus
S435VLNAFsQAPSTPRKDCHPRD
T159KLRRYtTFSKRDMPK_groupphosphoELM; RegPhos
T159KLRRYtTFSKRPKCa(PKC alphaRegPhos
S77AGALYsGSEGDCK2a1(CK2 alphaRegPhos

Dephosphorylation site
SRF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265354Q353HTCGAOvarian Cancer21720365, 18772890
ENSP00000265354Q353HCOSMICOvarian Cancer21720365
ENSP00000265354T393ACOSMICBreast Cancer20668451

Differential expressed protein
SRF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SRF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAPK2_HUMANSRF_HUMANkinase -> substrateRegPhos
KPCA_HUMANSRF_HUMANkinase -> substrateRobert H Newman (2013)
PRKDC_HUMANSRF_HUMANkinase -> substrateHPRD
DMPK_HUMANSRF_HUMANkinase -> substrateRegPhos
KS6A2_HUMANSRF_HUMANkinase -> substrateRegPhos
CSK21_HUMANSRF_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK08_HUMANSRF_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSRF_HUMANkinase -> substrateRegPhos
FGR_HUMANSRF_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANSRF_HUMANkinase -> substrateHPRD
STK16_HUMANSRF_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANSRF_HUMANkinase -> substrateHPRD
CDK5_HUMANSRF_HUMANkinase -> substrateRobert H Newman (2013)
SRF_HUMANDMD_HUMANTF -> target geneTRANSFAC
SRF_HUMANACTB_HUMANTF -> target geneTRANSFAC
ELK1_HUMANSRF_HUMANTF -> target geneTRANSFAC
SRF_HUMANFOS_HUMANTF -> target geneTRANSFAC
SRF_HUMANMYL3_HUMANTF -> target geneTRANSFAC
SRF_HUMANEGR1_HUMANTF -> target geneTRANSFAC
SRF_HUMANELK1_HUMANTF -> target geneTRANSFAC
SRF_HUMANAPOE_HUMANTF -> target geneTRANSFAC
SRF_HUMANEGR2_HUMANTF -> target geneTRANSFAC
SRF_HUMANACTC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04010MAPK signaling pathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060218hematopoietic stem cell differentiationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0010735positive regulation of transcription via serum resIDAbiological_process
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0007015actin filament organizationIEAbiological_process
GO:0035855megakaryocyte developmentIEAbiological_process
GO:0035912dorsal aorta morphogenesisIEAbiological_process
GO:0090398cellular senescenceIMPbiological_process
GO:0045987positive regulation of smooth muscle contractionIDAbiological_process
GO:0051491positive regulation of filopodium assemblyIEAbiological_process
GO:0048666neuron developmentTASbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0022028tangential migration from the subventricular zone IEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0001707mesoderm formationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043149stress fiber assemblyIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0001666response to hypoxiaIEPbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0042789mRNA transcription from RNA polymerase II promoterIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0016337cell-cell adhesionIEAbiological_process
GO:0003257positive regulation of transcription from RNA polyIEAbiological_process
GO:0033561regulation of water loss via skinIEAbiological_process
GO:0060261positive regulation of transcription initiation frIDAbiological_process
GO:0045059positive thymic T cell selectionIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0009725response to hormone stimulusIDAbiological_process
GO:0009636response to toxinTASbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0034097response to cytokine stimulusIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0070830tight junction assemblyIEAbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0001228RNA polymerase II transcription regulatory region IEAmolecular_function
GO:0001947heart loopingIEAbiological_process
GO:0008306associative learningIEAbiological_process
GO:0046716muscle cell homeostasisIEAbiological_process
GO:0060947cardiac vascular smooth muscle cell differentiatioIEAbiological_process
GO:0030168platelet activationIEAbiological_process
GO:0060292long term synaptic depressionIEAbiological_process
GO:0021766hippocampus developmentIEAbiological_process
GO:0002521leukocyte differentiationIEAbiological_process
GO:0051150regulation of smooth muscle cell differentiationTASbiological_process
GO:0010736serum response element bindingIEAmolecular_function
GO:0007369gastrulationIEAbiological_process
GO:0001829trophectodermal cell differentiationIDAbiological_process
GO:0090136epithelial cell-cell adhesionIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0002042cell migration involved in sprouting angiogenesisIEAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0030220platelet formationIEAbiological_process
GO:0000790nuclear chromatinIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0060055angiogenesis involved in wound healingTASbiological_process
GO:0060347heart trabecula formationIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045597positive regulation of cell differentiationIDAbiological_process
GO:0048821erythrocyte developmentIEAbiological_process
GO:1900222negative regulation of beta-amyloid clearanceIMPbiological_process
GO:0030038contractile actin filament bundle assemblyIEAbiological_process
GO:0001076RNA polymerase II transcription factor binding traIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0061029eyelid development in camera-type eyeIEAbiological_process
GO:0090009primitive streak formationIEAbiological_process
GO:0002011morphogenesis of an epithelial sheetIEAbiological_process
GO:0000978RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045214sarcomere organizationIEAbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region ISSmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0010669epithelial structure maintenanceIEAbiological_process
GO:0055003cardiac myofibril assemblyIEAbiological_process
GO:0000983RNA polymerase II core promoter sequence-specific IMPmolecular_function
GO:0043589skin morphogenesisIEAbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process