| UniProt/SwissProt ID: | MAX_HUMAN |
| Description: | MYC associated factor X [Source:HGNC Symbol;Acc:6913] |
| Location: | chr14 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S138 | AFDGGsDSSSE | CK2a1 | RegPhos |
| S2 | MSDNDdI | CK2a1 | RegPhos |
| S140 | DGGSDsSSESE | CK2a1 | RegPhos |
| S141 | GGSDSsSESEP | CK2a1-rs | RegPhos |
| S11 | DIEVEsDADKR | HPRD | |
| S142 | GSDSSsESEPE | CSNK2A1 | HPRD |
| S42 | DHIKDsFHSLR | Filament; ATG16; HLH; Myo | PhosphoSitePlus |
| S123 | KGSTIsAFDGG | HPRD | |
| S129 | AFDGGsDSSSE | CSNK2A1 | HPRD |
| S11 | DIEVEsDEEQP | CK2_group | phosphoELM; RegPhos |
| S140 | DGGSDsSSESE | CSNK2A1 | HPRD |
| S141 | GGSDSsSESEP | CSNK2A1 | HPRD |
| S138 | AFDGGsDSSSE | CSNK2A1 | HPRD |
| S2 | MSDNDdI | CK2a1(CK2 alpha | RegPhos |
| S144 | DSSSEsEPEEP | CSNK2A1 | HPRD |
| S2 | ____MsDNDDI | Filament; ATG16; Myosin_t | PhosphoSitePlus |
| T124 | DNSLYtNAKGS | Filament; CENP-Q; Tropomy | PhosphoSitePlus |
| S144 | DSSSEsEPEEP | CENP-Q | PhosphoSitePlus |
| T68 | ILDKAtEYIQY | Filament; ATG16; HLH; Myo | PhosphoSitePlus |
| S135 | DSSSEsEPEEP | MAPK14 | HPRD |
| S40 | HSLRDsVPSLQ | MAPK14 | HPRD |
| S132 | GGSDSsSESEP | CSNK2A1 | HPRD |
| Y123 | SDNSLyTNAKG | HPRD; phosphoELM; RegPhos | |
| S11 | DIEVEsDEEQP | Filament; ATG16; Myosin_t | PhosphoSitePlus |
| S142 | GSDSSsESEPE | CK2a1 | RegPhos |
| S2 | MSDNDdI | CK2_group | RegPhos |
| S131 | DGGSDsSSESE | CSNK2A1 | HPRD |
| S129 | TNAKGsTISAF | CK2a1 | RegPhos |
| S2 | NDDI | CK2_group | phosphoELM |
| S132 | KGSTIsAFDGG | CK2a1-rs | RegPhos |
| S49 | HSLRDsVPSLQ | p38a | RegPhos |
| S2 | NDDI | phosphoELM | |
| S45 | KDSFHsLRDSV | Filament; ATG16; HLH; Myo | PhosphoSitePlus |
| S121 | PSSDNsLYTNA | Filament; Fib_alpha; CENP | PhosphoSitePlus |
| S49 | HSLRDsVPSLQ | MAPK14 | HPRD |
| S11 | DIEVEsDEEQP | CK2a1 | RegPhos |
| S11 | DIEVEsDEEQP | CSNK2A1 | HPRD |
| S2 | NDDI | CK2_alpha | phosphoELM |
| S144 | DSSSEsEPEEP | CK2a1-rs | RegPhos |
| S141 | GGSDSsSESEP | CK2a1 | RegPhos |
| S144 | DSSSEsEPEEP | MAPK14 | HPRD |
| S138 | AFDGGsDSSSE | CK2a1-rs | RegPhos |
| S11 | DIEVEsDEEQP | CK2a1(CK2 alpha | RegPhos |
| S11 | DIEVEsDEEQP | CK2a1-rs | RegPhos |
| S140 | DGGSDsSSESE | CK2a1-rs | RegPhos |
| S132 | KGSTIsAFDGG | HPRD | |
| Y115 | QLQTNyPSSDN | Filament; Myosin_tail_1; | PhosphoSitePlus |
| S144 | DSSSEsEPEEP | CK2a1 | RegPhos |
| S2 | NDDI | CSNK2A1 | HPRD |
| S144 | DSSSEsEPEEP | p38a | RegPhos |
| S11 | DIEVEsDEEQP | phosphoELM; RegPhos | |
| S132 | KGSTIsAFDGG | CK2a1 | RegPhos |
| Y73 | TEYIQyMRRKN | Filament; ATG16; HLH; Myo | PhosphoSitePlus |
| S2 | MSDNDdI | RegPhos | |
| Y114 | SDNSLyTNAKG | HPRD | |
| Y70 | DKATEyIQYMR | Filament; ATG16; HLH; Myo | PhosphoSitePlus |
| S142 | GSDSSsESEPE | CK2a1-rs | RegPhos |
| S133 | GSDSSsESEPE | CSNK2A1 | HPRD |
| Y123 | SDNSLyTNAKG | Filament; CENP-Q; Tropomy | PhosphoSitePlus |
| S129 | TNAKGsTISAF | CK2a1-rs | RegPhos |
| S135 | DSSSEsEPEEP | CSNK2A1 | HPRD |
| S140 | DGGSDsSSESE | CENP-Q | PhosphoSitePlus |
| S11 | DIEVEsDEEQP | CK2_alpha | phosphoELM |
| S2 | MSDNDdI | CK2a1-rs | RegPhos |
| Dephosphorylation site |
| MAX_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000351490 | Y123C | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| MAX_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MAX_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK14_HUMAN | MAX_HUMAN | kinase -> substrate | KEGG; HPRD |
| CSK21_HUMAN | MAX_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK13_HUMAN | MAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | MAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | MAX_HUMAN | kinase -> substrate | RegPhos |
| HIPK1_HUMAN | MAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa05222 | Small cell lung cancer |
| hsa05200 | Pathways in cancer |
| hsa05202 | Transcriptional misregulation in cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0032868 | response to insulin stimulus | IEA | biological_process |
| GO:0006461 | protein complex assembly | IEA | biological_process |
| GO:0071375 | cellular response to peptide hormone stimulus | IEA | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0010243 | response to organic nitrogen | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0003712 | transcription cofactor activity | TAS | molecular_function |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0009267 | cellular response to starvation | IEA | biological_process |
| GO:0030425 | dendrite | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0048678 | response to axon injury | IEA | biological_process |
| GO:0010629 | negative regulation of gene expression | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0051402 | neuron apoptotic process | IEA | biological_process |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0060041 | retina development in camera-type eye | IEA | biological_process |
| GO:0032403 | protein complex binding | IEA | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |