Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BRCA1_HUMAN
Description:breast cancer 1, early onset [Source:HGNC Symbol;Acc:1100]
Location:chr17 q21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1212KKLESsEENLSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S840HEVNHsRETSIRegPhos
T1394SDILTtQQRDTATRHPRD; RegPhos
S451RVHSKsVESNIBRCT_assocPhosphoSitePlus
Y1202HLAQGyRRGAKHPRD
S1460LTSQKsSEYPIPhosphoSitePlus; HPRD
S389EWFSRsDELLGP67870(Casein kinase II )RegPhos
S803PNKCVsQCAAFEIN3PhosphoSitePlus
S1423LEQHGsQPSNSATMHPRD; phosphoELM; RegPhos
S1423LEQHGsQPSNSATRHPRD; phosphoELM; RegPhos
S398LGSDDsHDGESHPRD; phosphoELM
T1720SYFWVtQSIKEBRCTPhosphoSitePlus
S1457KAVLTsQKSSEPhosphoSitePlus; phosphoELM
S426EYSGSsEKIDLBRCT_assocPhosphoSitePlus
S1330RHQSEsQGVGLPhosphoSitePlus; phosphoELM; RegPhos
S694SKRHDsDTFPEEIN3PhosphoSitePlus
S1466SEYPIsQNPEGPhosphoSitePlus; phosphoELM; RegPhos
S1572GISLFsDDPESP67870(Casein kinase II )RegPhos
T509RKRRPtSGLHPPhosphoSitePlus
S320LEQHGsQPSNSATRHPRD
S425DEYSGsSEKIDBRCT_assocPhosphoSitePlus
T1700FVCERtLKYFLHPRD; phosphoELM; RegPhos
S308EFCNKsKQPGLAURKAHPRD
S473SDDPEsDPSEDHPRD
S1483EVSADsSTSKNATMRegPhos
S434IDLLAsDPHEAHPRD
S1613AESAQsPAAAHPhosphoSitePlus
S398LGSDDsHDGESATMRegPhos
T967ETGLItPNKHGEIN3PhosphoSitePlus
S616LRRKSsTRHIHPhosphoSitePlus
S1187QKGELsRSPSPPhosphoSitePlus; HPRD
S694SKRHDsDTFPEHPRD
S1217SEENLsSEDEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S123LKDEVsIIQSMPhosphoSitePlus
T616SYFWVtQSIKEHPRD
S1542QQLEEsGPHDLATMHPRD; RegPhos
S395DELLGsDDSHDBRCT_assocPhosphoSitePlus
S1143GSSHAsQVCSEPhosphoSitePlus
S1191LSRSPsPFTHTPhosphoSitePlus; HPRD
S426EYSGSsEKIDLHPRD
S1007NFEEHsMSPERHPRD
S1164IKEDTsFAENDHPRD
S1280ILAKAsQEHHLPhosphoSitePlus
S1466SEYPIsQNPEGATMHPRD; phosphoELM; RegPhos
S423EVDEYsGSSEKBRCT_assocPhosphoSitePlus
S1009EEHSMsPEREMHPRD
S1497GVERSsPSKCPPhosphoSitePlus
Y978LLQNPyRIPPLEIN3PhosphoSitePlus
S1542QQLEEsGPHDLPhosphoSitePlus; phosphoELM; RegPhos
S1387CSGLSsQSDILPhosphoSitePlus
S1330RHQSEsQGVGLATMHPRD; phosphoELM; RegPhos
S454SKSVEsNIEDKBRCT_assocPhosphoSitePlus
S1211AKKLEsSEENLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1342DKELVsDDEERPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S988LFPIKsFVKTKCHK2phosphoELM; RegPhos
S1499ERSSPsKCPSLHPRD; phosphoELM; RegPhos
S1423LEQHGsQPSNSPhosphoSitePlus
S308EFCNKsKQPGLAurora AphosphoELM
S647DSCSSsEEIKKPhosphoSitePlus
S1178SSAVFsKSVQKPhosphoSitePlus
S434IDLLAsDPHEABRCT_assocPhosphoSitePlus
S1280ILAKAsQEHHLATRHPRD; RegPhos
T291SDILTtQQRDTATRHPRD
S1286QEHHLsEETKCPhosphoSitePlus; HPRD
S1143GSSHAsQVCSEATRHPRD; RegPhos
S753KDLMLsGERVLHPRD; phosphoELM
S1189GELSRsPSPFTPhosphoSitePlus; phosphoELM; RegPhos
T509RKRRPtSGLHPAKT_groupRegPhos
S615RLRRKsSTRHIPhosphoSitePlus
S510KRRPTsGLHPEPhosphoSitePlus
S1572GISLFsDDPESPhosphoSitePlus
T1777FTNMPtDQLEWBRCTPhosphoSitePlus
S1336QGVGLsDKELVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T164LGTVRtLRTKQPhosphoSitePlus
S308EFCNKsKQPGLPhosphoSitePlus
S1497GVERSsPSKCPCDK_groupRegPhos
S1457KAVLTsQKSSEATMHPRD; phosphoELM; RegPhos
S1457KAVLTsQKSSEATRHPRD; phosphoELM; RegPhos
S284CSGLSsQSDILATMHPRD
S1239VNNIPsQSTRHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S308EFCNKsKQPGLAurARegPhos
S398LGSDDsHDGESBRCT_assocPhosphoSitePlus
S420NRNYPsQEELIHPRD
S632VSRNLsPPNCTPhosphoSitePlus
S423EVDEYsGSSEKHPRD
S438QQLEEsGPHDLHPRD
T1720SYFWVtQSIKEHPRD; phosphoELM; RegPhos
S1572GISLFsDDPESCK2a1-rsRegPhos
S1239VNNIPsQSTRHATRRegPhos
S114KKENNsPEHLKPhosphoSitePlus; HPRD
S1524NRNYPsQEELIPhosphoSitePlus; phosphoELM
T596FVCERtLKYFLHPRD
S1328QMRHQsESQGVPhosphoSitePlus; HPRD
T208ELLQItPQGTRPhosphoSitePlus
S1497GVERSsPSKCPCDK2HPRD; phosphoELM; RegPhos
S395DELLGsDDSHDHPRD; phosphoELM
S1524NRNYPsQEELIATRHPRD; phosphoELM; RegPhos
S988LFPIKsFVKTKPhosphoSitePlus
S741ETVKVsNNAEDEIN3PhosphoSitePlus
S1387CSGLSsQSDILATRHPRD; RegPhos
S1387CSGLSsQSDILATMHPRD; phosphoELM; RegPhos
S1524NRNYPsQEELIATMHPRD; phosphoELM; RegPhos
T1700FVCERtLKYFLBRCTPhosphoSitePlus
S1245QSTRHsTVATEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1218EENLSsEDEELPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S403SHDGEsESNAKHPRD; phosphoELM
S281TNTHAsSLQHEATMRegPhos
S281TNTHAsSLQHEATRRegPhos
S1577SDDPEsDPSEDPhosphoSitePlus; HPRD
S1572GISLFsDDPESCSNK2A1HPRD
S1189GELSRsPSPFTATMHPRD; RegPhos
T509AESAQsPAAAHAKT1HPRD
S1572GISLFsDDPESCK2a1RegPhos
T967ETGLItPNKHGCDK2RegPhos
S1483EVSADsSTSKNPhosphoSitePlus
T509RKRRPtSGLHPAKT1HPRD; RegPhos
T1194SPSPFtHTHLAPhosphoSitePlus
T617RRKSStRHIHAPhosphoSitePlus
S1497GVERSsPSKCPATMphosphoELM
T509RKRRPtSGLHPPKB_groupphosphoELM
S988LFPIKsFVKTKCHEK2HPRD
S405DGESEsNAKVAHPRD; phosphoELM
T1196SPFTHtHLAQGHPRD
S1790QLCGAsVVKELBRCTPhosphoSitePlus
S753KDLMLsGERVLEIN3PhosphoSitePlus
S356LTSQKsSEYPIHPRD
T1550HDLTEtSYLPRPhosphoSitePlus
S320LEQHGsQPSNSATMHPRD

Dephosphorylation site
BRCA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350283M18THPIBreast Cancer8807330 17924331 21372787
ENSP00000350283M1775KOMIMBreast Cancer18285836
ENSP00000350283I1766SHPIBreast Cancer8807330 17924331
ENSP00000350283A1708EHPIBreast Cancer8807330 7939630 17924331 21063910 20960228 17063491 18036263 17080309 16758124 15923272 15184261 11802208 12400015 11916966 12645254 11157798 10737987 9523200 8942979 8872468
ENSP00000350283G960DHPIBreast Cancer8807330 9609997
ENSP00000350283G813fs*2COSMICOvarian Cancer21720365
ENSP00000350283P1150SHPIBreast Cancer8807330 8723683
ENSP00000350283S988*COSMICBreast Cancer22116506
ENSP00000350283Y465DHPIBreast Cancer8807330 9609997
ENSP00000350283M1411THPIOvarian Cancer8807330 14746861
ENSP00000350283C61GHPIOvarian Cancer9528852 8807330 7894493 8554067 9760198 12938098 14746861 21344391 22172724 20345474 20967475 20960228 20862552 20825051 20569256 20507347 19887647 19594371 19543972 19287951 19372713 18090912 19140568 18798010 18489799 18243530 18405391
ENSP00000350283K309QCOSMICBreast Cancer22116506
ENSP00000350283S1715RHPIBreast Cancer8807330 17924331
ENSP00000350283L1786PHPIBreast Cancer8807330 12938098
ENSP00000350283E1011KCOSMICBreast Cancer20668451
ENSP00000350283R1204IHPIBreast Cancer8807330 14722926
ENSP00000350283T1025IHPIBreast Cancer8807330 9609997
ENSP00000350283D1692NHPIOvarian Cancer8807330 11157798
ENSP00000350283K1207NHPIBreast Cancer8807330 14722926
ENSP00000350283G1706EHPIBreast Cancer8807330 17924331
ENSP00000350283V1047AHPIBreast Cancer8807330 9609997
ENSP00000350283S1297PHPIBreast Cancer8807330 12938098
ENSP00000350283L30FSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421, 8807330, 8807330, 16959974, 8807330 16959974
ENSP00000350283Y856HHPIBreast Cancer8807330 15365993
ENSP00000350283G1710fs*4COSMICOvarian Cancer21720365
ENSP00000350283V370ICOSMICBreast Cancer20668451
ENSP00000350283M1628THPIBreast Cancer8807330 15365993 15689452 15350310
ENSP00000350283R1243GHPIBreast Cancer8807330 14722926
ENSP00000350283S1187IHPIBreast Cancer8807330 14722926
ENSP00000350283G552VHPIBreast Cancer8807330 9609997
ENSP00000350283V757fs*8COSMICOvarian Cancer9796975
ENSP00000350283G778CSjoblom2006, COSMIC, HPIBreast Cancer16959974, 8807330, 8807330, 16959974, 8807330 16959974
ENSP00000350283R1835*COSMICOvarian Cancer21720365
ENSP00000350283M1689RHPIBreast Cancer8807330 17924331
ENSP00000350283G817fs*29COSMICOvarian Cancer9796975
ENSP00000350283P1812SHPIOvarian Cancer8807330
ENSP00000350283S1140GCOSMICBreast Cancer19593635
ENSP00000350283C47WCOSMICOvarian Cancer21720365
ENSP00000350283L892SHPIBreast Cancer8807330 9609997
ENSP00000350283P1749RHPIOvarian Cancer11301010 15133502 8807330 10486320 8872468
ENSP00000350283S1139IHPIBreast Cancer8807330 12938098
ENSP00000350283D749YHPIBreast Cancer8807330 12442275
ENSP00000350283V271MHPIBreast Cancer8807330 8723683
ENSP00000350283E23KHPIBreast Cancer8807330 14722926
ENSP00000350283C1697RHPIOvarian Cancer8807330 14746861 11157798
ENSP00000350283A521fs*11COSMICOvarian Cancer21720365
ENSP00000350283E1644*COSMICLung Cancer20668451
ENSP00000350283A1641PHPIOvarian Cancer8807330
ENSP00000350283G1788VHPIBreast Cancer8807330 17924331
ENSP00000350283C64GOMIM, HPIBreast Cancer7894491, 9528852 8807330 7894491 9482581 19287957 8653694
ENSP00000350283R71GOMIMBreast Cancer12014998 11385711 12955716
ENSP00000350283E730*COSMICOvarian Cancer9796975
ENSP00000350283G1077WDing2008, COSMICLung Cancer18948947
ENSP00000350283E1288fs*19COSMICBreast Cancer15712267
ENSP00000350283T1685AHPIBreast Cancer8807330 17924331
ENSP00000350283C61GOMIMBreast Cancer10788334 7795652
ENSP00000350283S1009*COSMICOvarian Cancer10467410
ENSP00000350283R1751*COSMICBreast Cancer
ENSP00000350283H835YHPIBreast Cancer8807330 12938098
ENSP00000350283R71KHPIBreast Cancer8807330 12938098
ENSP00000350283P724fs*12COSMICBreast Cancer19593635
ENSP00000350283S451*COSMICBreast Cancer21233401
ENSP00000350283E1210GHPIBreast Cancer8807330 12938098
ENSP00000350283M297VCOSMICLung Cancer20668451
ENSP00000350283T826KHPIBreast Cancer8807330
ENSP00000350283R1443GOMIMBreast Cancer7894491
ENSP00000350283L1764PHPIBreast Cancer8807330 17924331
ENSP00000350283E116*COSMICOvarian Cancer21720365
ENSP00000350283Q1420*COSMICOvarian Cancer9796975
ENSP00000350283P1776SHPIOvarian Cancer8807330
ENSP00000350283K38NCOSMICBreast Cancer22116506
ENSP00000350283R1495MHPIBreast Cancer8807330 17924331
ENSP00000350283H888YHPIBreast Cancer8807330 12938098
ENSP00000350283L431*COSMICOvarian Cancer21720365
ENSP00000350283L22SHPIBreast Cancer8807330 9609997 19543972
ENSP00000350283F1226LHPIBreast Cancer8807330 14722926
ENSP00000350283S114TCOSMICOther Cancer
ENSP00000350283Q1538*COSMICOvarian Cancer21720365
ENSP00000350283W372*COSMICBreast Cancer15712267
ENSP00000350283A1814fs*20COSMICOvarian Cancer7795636
ENSP00000350283P346SHPIBreast Cancer8807330 10323242
ENSP00000350283S1040NOMIMBreast Cancer7894493
ENSP00000350283S1217YHPIBreast Cancer8807330 14722926
ENSP00000350283R841WOMIM, HPIBreast Cancer8968716, 8807330 8968716 9760198 18798010 15290653 12070551 9585599
ENSP00000350283L758FSjoblom2006, COSMIC, HPIBreast Cancer16959974, 8807330, 8807330, 16959974, 8807330 16959974
ENSP00000350283Q1200HHPIBreast Cancer8807330 14722926
ENSP00000350283G275DCOSMICBreast Cancer22116506
ENSP00000350283E10KHPIBreast Cancer8807330 14722926
ENSP00000350283E227KHPIOvarian Cancer8807330
ENSP00000350283Q687PCOSMICLung Cancer20668451
ENSP00000350283I986MCOSMICBreast Cancer20668451
ENSP00000350283F461LHPIBreast Cancer8807330 9609997
ENSP00000350283R866QHPIBreast Cancer8807330 12938098
ENSP00000350283E1725*COSMICOvarian Cancer7795652
ENSP00000350283G1738RHPIBreast Cancer8807330 17924331
ENSP00000350283K1690QHPIBreast Cancer8807330 15365993
ENSP00000350283M1775KHPIBreast Cancer18285836 8807330
ENSP00000350283R1699WHPIOvarian Cancer8807330 14746861 17924331 21473589 19200354 17574969 17493881 11157798 12496476

Differential expressed protein
BRCA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S1387EDCSGLSsQSDILTTataxia-telangiectasia10866324PhosphoSitePlus
S1423AVLEQHGsQPSNSYPataxia-telangiectasia10866324PhosphoSitePlus
S1457SEKAVLTsQKSSEYPataxia-telangiectasia10866324PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CSK2B_HUMANBRCA1_HUMANkinase -> substrateHPRD
ATR_HUMANBRCA1_HUMANkinase -> substrateRegPhos
AURKA_HUMANBRCA1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANBRCA1_HUMANkinase -> substrateRegPhos
ATM_HUMANBRCA1_HUMANkinase -> substrateRegPhos
MK08_HUMANBRCA1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANBRCA1_HUMANkinase -> substrateHPRD
CHK2_HUMANBRCA1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
PLK3_HUMANBRCA1_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANBRCA1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANBRCA1_HUMANkinase -> substrateHPRD; RegPhos
CDK2_HUMANBRCA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis
hsa03460Fanconi anemia pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006359regulation of transcription from RNA polymerase IITASbiological_process
GO:0035067negative regulation of histone acetylationIEAbiological_process
GO:0031436BRCA1-BARD1 complexIDAcellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0008274gamma-tubulin ring complexNAScellular_component
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0006974response to DNA damage stimulusTASbiological_process
GO:0046600negative regulation of centriole replicationNASbiological_process
GO:0031572G2/M transition DNA damage checkpointIMPbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007059chromosome segregationIMPbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0008630intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0015631tubulin bindingNASmolecular_function
GO:0006978DNA damage response, signal transduction by p53 clTASbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0009048dosage compensation by inactivation of X chromosomIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0042127regulation of cell proliferationTASbiological_process
GO:0007098centrosome cycleIEAbiological_process
GO:2000617positive regulation of histone H3-K9 acetylationIEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0003713transcription coactivator activityNASmolecular_function
GO:0051574positive regulation of histone H3-K9 methylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0045739positive regulation of DNA repairIMPbiological_process
GO:0031941filamentous actinIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0035066positive regulation of histone acetylationIDAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0071681cellular response to indole-3-methanolIDAbiological_process
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0006302double-strand break repairIMPbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0001726ruffleIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0034446substrate adhesion-dependent cell spreadingIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005694chromosomeISScellular_component
GO:0016567protein ubiquitinationIDAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0006301postreplication repairIDAbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0045717negative regulation of fatty acid biosynthetic proIMPbiological_process
GO:0070512positive regulation of histone H4-K20 methylationIEAbiological_process
GO:0071158positive regulation of cell cycle arrestIDAbiological_process
GO:0031398positive regulation of protein ubiquitinationIDAbiological_process
GO:0000724double-strand break repair via homologous recombinIDAbiological_process
GO:0085020protein K6-linked ubiquitinationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0051571positive regulation of histone H3-K4 methylationIEAbiological_process
GO:0051573negative regulation of histone H3-K9 methylationIEAbiological_process
GO:0010212response to ionizing radiationIMPbiological_process
GO:0000151ubiquitin ligase complexNAScellular_component
GO:0043009chordate embryonic developmentIEAbiological_process
GO:2000620positive regulation of histone H4-K16 acetylationIEAbiological_process
GO:0051572negative regulation of histone H3-K4 methylationIEAbiological_process
GO:0006349regulation of gene expression by genetic imprintinIEAbiological_process
GO:0043627response to estrogen stimulusIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0070531BRCA1-A complexIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenTASbiological_process
GO:0000794condensed nuclear chromosomeIEAcellular_component
GO:0044030regulation of DNA methylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:2000145regulation of cell motilityIDAbiological_process
GO:0006633fatty acid biosynthetic processIEAbiological_process