Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SCG1_HUMAN
Description:chromogranin B (secretogranin 1) [Source:HGNC Symbol;Acc:1930]
Location:chr20 p12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S301GGSLPsEEKGHHPRD
S317EESNVsMASLGGraninPhosphoSitePlus
Y429GEPRAyFMSDTGraninPhosphoSitePlus
S377APRPQsEESWDGraninPhosphoSitePlus
S405GYGEEsEEERGHPRD
Y173EEGENyQKGERGraninPhosphoSitePlus
S183RGEDSsEEKHLGraninPhosphoSitePlus
S311HPQEEsEESNVHPRD
S259KGQPRsQEESEGraninPhosphoSitePlus
S183RGEDSsEEKHLHPRD
S626PDFYDsEEPVSGraninPhosphoSitePlus
Y506FQDKQySSHHTGraninPhosphoSitePlus
Y401KMAHGyGEESEGraninPhosphoSitePlus
S335THYRAsEEEPEGraninPhosphoSitePlus
S130EGGGHsRERADHPRD
S182ERGEDsSEEKHGraninPhosphoSitePlus
S259KGQPRsQEESEHPRD
Y526LFNPYyDPLQWGraninPhosphoSitePlus
S149SDSQVsEEVKTHPRD; phosphoELM
S617HYRKKsAEFPDHPRD
S405GYGEEsEEERGGraninPhosphoSitePlus
S182ERGEDsSEEKHHPRD
S626PDFYDsEEPVSHPRD
S311HPQEEsEESNVGraninPhosphoSitePlus
S263RSQEEsEEGEEGraninPhosphoSitePlus
S617HYRKKsAEFPDGraninPhosphoSitePlus
S263RSQEEsEEGEEHPRD
Y341EEEPEyGEEIKGraninPhosphoSitePlus
S377APRPQsEESWDHPRD
S301GGSLPsEEKGHGraninPhosphoSitePlus
Y525ELFNPyYDPLQGraninPhosphoSitePlus
S149SDSQVsEEVKTGraninPhosphoSitePlus
Y389EDKRNyPSLELGraninPhosphoSitePlus
Y332HHSTHyRASEEGraninPhosphoSitePlus
Y613DQLLHyRKKSAGraninPhosphoSitePlus

Dephosphorylation site
SCG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368244G366ECOSMICMelanoma21499247
ENSP00000368244N558KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000368244R469SCOSMICOvarian Cancer21720365
ENSP00000416643G150EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000368244R469STCGAOvarian Cancer21720365, 18772890
ENSP00000368244L85FCOSMICMelanoma21499247
ENSP00000368244G126ECOSMICHead and Neck Cancer21984974
ENSP00000416643A185SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000368244A205SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000368244Q449*COSMICSkin Cancer21984974
ENSP00000368244G170EBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000368244R258QCOSMICBreast Cancer20393555
ENSP00000368244N473SCOSMICSkin Cancer21984974

Differential expressed protein
SCG1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SCG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK1_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
MAST2_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
KPCT_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SCG1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0030141secretory granuleIEAcellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005179hormone activityTASmolecular_function


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