Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PKD2_HUMAN
Description:polycystic kidney disease 2 (autosomal dominant) [Source:HGNC Symbol;Acc:9009]
Location:chr4 q22.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S408AAQVAsLKKNVPKD_channelPhosphoSitePlus
S80PSPPLsSCSRQPhosphoSitePlus
S263LDTPVsKTEKTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S254YTRMMsQLFLDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S858IGSIVsKIDAVphosphoELM; RegPhos
S76AAASPsPPLSSPhosphoSitePlus
S801LPRPMsSRSFPPhosphoSitePlus
S812RSLDDsEEDDDCK2a1(CK2 alphaRegPhos
S949SRPSSsQSTEGPhosphoSitePlus; HPRD
S138SVGARsRGLGGPhosphoSitePlus
S812RSLDDsEEDDDCK2_alphaphosphoELM
S852DRMEHsIGSIVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T952SSSQStEGMEGPhosphoSitePlus
S591LSTTMsRCAKDPKD_channelPhosphoSitePlus
S812RSLDDsEEDDDPhosphoSitePlus; HPRD
T260QLFLDtPVSKTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S307EADNRsFIFYEPKD_channelPhosphoSitePlus
S166GPPCPsPVGGGPhosphoSitePlus; HPRD; RegPhos; SysPTM

Dephosphorylation site
PKD2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000237596E740KCOSMICSkin Cancer21984974
ENSP00000237596G202RCOSMICMelanoma21499247
ENSP00000237596R592QCOSMICHead and Neck Cancer21798893
ENSP00000237596S829CCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000237596Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.1315169874

Hyperphosphorylation site
PKD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKD2_HUMANKPCD2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANPKD2_HUMANkinase -> substrateRegPhos
CSK21_HUMANPKD2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PKD2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030814regulation of cAMP metabolic processIEAbiological_process
GO:0015267channel activityIEAmolecular_function
GO:0055085transmembrane transportIEAbiological_process
GO:0072075metanephric mesenchyme developmentIEPbiological_process
GO:0050982detection of mechanical stimulusIEAbiological_process
GO:0072177mesonephric duct developmentIEPbiological_process
GO:0009925basal plasma membraneIDAcellular_component
GO:0048763calcium-induced calcium release activityIDAmolecular_function
GO:0071458integral to cytosolic side of endoplasmic reticuluIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0061441renal artery morphogenesisIEPbiological_process
GO:0008092cytoskeletal protein bindingIDAmolecular_function
GO:0060315negative regulation of ryanodine-sensitive calciumIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEPbiological_process
GO:0061371determination of heart left/right asymmetryIMPbiological_process
GO:0071556integral to lumenal side of endoplasmic reticulum IDAcellular_component
GO:0008285negative regulation of cell proliferationNASbiological_process
GO:0044325ion channel bindingIPImolecular_function
GO:0042805actinin bindingIDAmolecular_function
GO:0005244voltage-gated ion channel activityIDAmolecular_function
GO:0005789endoplasmic reticulum membraneIDAcellular_component
GO:0071158positive regulation of cell cycle arrestIMPbiological_process
GO:0042127regulation of cell proliferationIMPbiological_process
GO:0006811ion transportIEAbiological_process
GO:0001889liver developmentIEPbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0045180basal cortexIEAcellular_component
GO:0031512motile primary ciliumIEAcellular_component
GO:0035904aorta developmentIEPbiological_process
GO:0072164mesonephric tubule developmentIEPbiological_process
GO:0051117ATPase bindingIEAmolecular_function
GO:0090279regulation of calcium ion importIDAbiological_process
GO:0051209release of sequestered calcium ion into cytosolIEAbiological_process
GO:0006816calcium ion transportISSbiological_process
GO:0035502metanephric part of ureteric bud developmentIEPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071805potassium ion transmembrane transportIEAbiological_process
GO:0044441cilium partIEAcellular_component
GO:0031659positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0007368determination of left/right symmetryISSbiological_process
GO:0005245voltage-gated calcium channel activityIDAmolecular_function
GO:0005102receptor bindingIEAmolecular_function
GO:0051298centrosome duplicationNASbiological_process
GO:0034614cellular response to reactive oxygen speciesNASbiological_process
GO:0005929ciliumIEAcellular_component
GO:0071470cellular response to osmotic stressIDAbiological_process
GO:0072208metanephric smooth muscle tissue developmentIEPbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0070588calcium ion transmembrane transportIDAbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:2000134negative regulation of G1/S transition of mitotic IMPbiological_process
GO:0072686mitotic spindleIEAcellular_component
GO:0022843voltage-gated cation channel activityIDAmolecular_function
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0072219metanephric cortical collecting duct developmentIEPbiological_process
GO:0005216ion channel activityIEAmolecular_function
GO:0002133polycystin complexIEAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0003127detection of nodal flowIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005932microtubule basal bodyIDAcellular_component
GO:0071464cellular response to hydrostatic pressureIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0031587positive regulation of inositol 1,4,5-trisphosphatIMPbiological_process
GO:0072218metanephric ascending thin limb developmentIEPbiological_process
GO:0072235metanephric distal tubule developmentIEPbiological_process
GO:0043398HLH domain bindingIPImolecular_function
GO:0006816calcium ion transportIEAbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0021915neural tube developmentIEPbiological_process
GO:0005929ciliumISScellular_component
GO:0007050cell cycle arrestIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0072284metanephric S-shaped body morphogenesisIEPbiological_process
GO:0007259JAK-STAT cascadeIEAbiological_process
GO:0031941filamentous actinIDAcellular_component
GO:0031513nonmotile primary ciliumIEAcellular_component
GO:0042994cytoplasmic sequestering of transcription factorIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0021510spinal cord developmentIEPbiological_process
GO:0071498cellular response to fluid shear stressIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0005248voltage-gated sodium channel activityIDAmolecular_function
GO:0035725sodium ion transmembrane transportIDAbiological_process
GO:0061333renal tubule morphogenesisIEAbiological_process
GO:0072214metanephric cortex developmentIEPbiological_process
GO:0060674placenta blood vessel developmentIEAbiological_process
GO:0005267potassium channel activityIEAmolecular_function