Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAGP1_HUMAN
Description:Ran GTPase activating protein 1 [Source:HGNC Symbol;Acc:9854]
Location:chr22 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S358VLASLsDDEDESigma70_ner; Plasmodium_VPhosphoSitePlus
T419ILDPNtGEPAPHPRD
T436PADVStFLAFPPlasmodium_Vir; CDC45; RRPhosphoSitePlus
S453RLGPKsSVLIAHPRD
S358VLASLsDDEDECK2a1RegPhos
T409GEKSAtPSRKISigma70_ner; Plasmodium_VPhosphoSitePlus
S478FLKVSsVFKDEPlasmodium_Vir; RRN3; YcfPhosphoSitePlus
S453RLGPKsSVLIAPlasmodium_Vir; CDC45; RRPhosphoSitePlus
S358VLASLsDDEDEphosphoELM
S442FLAFPsPEKLLHPRD; phosphoELM; RegPhos; SysPTM
T485FKDEAtVRMAVHPRD
T485FKDEAtVRMAVPlasmodium_Vir; RRN3; YcfPhosphoSitePlus
S478FLKVSsVFKDEHPRD
T436PADVStFLAFPHPRD; phosphoELM; RegPhos
S428APVLSsPPPADPlasmodium_Vir; CPSF100_CPhosphoSitePlus
S29SFKGKsLKLNTPhosphoSitePlus
S428APVLSsPPPADHPRD; phosphoELM; RegPhos
S427PAPVLsSPPPAPlasmodium_Vir; CPSF100_CPhosphoSitePlus
Y585LLQTLyKV___RanGAP1_CPhosphoSitePlus
S24AGGQLsFKGKSHPRD
S435PPADVsTFLAFPlasmodium_Vir; Drc1-Sld2PhosphoSitePlus
T409GEKSAtPSRKICDK1phosphoELM
S442FLAFPsPEKLLPlasmodium_Vir; CDC45; RRPhosphoSitePlus; SysPTM
S358VLASLsDDEDECSNK2A1HPRD
S427PAPVLsSPPPAHPRD; phosphoELM
S358VLASLsDDEDECK2a1-rsRegPhos

Dephosphorylation site
RAGP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348577E391KCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000401470Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
RAGP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRAGP1_HUMANkinase -> substrateRegPhos
CSK21_HUMANRAGP1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03013RNA transport

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032853positive regulation of Ran GTPase activityTASbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0000922spindle poleIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0046826negative regulation of protein export from nucleusIDAbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0005098Ran GTPase activator activityIEAmolecular_function
GO:0005643nuclear poreTAScellular_component


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