| UniProt/SwissProt ID: | RAGP1_HUMAN |
| Description: | Ran GTPase activating protein 1 [Source:HGNC Symbol;Acc:9854] |
| Location: | chr22 q13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S358 | VLASLsDDEDE | Sigma70_ner; Plasmodium_V | PhosphoSitePlus |
| T419 | ILDPNtGEPAP | HPRD | |
| T436 | PADVStFLAFP | Plasmodium_Vir; CDC45; RR | PhosphoSitePlus |
| S453 | RLGPKsSVLIA | HPRD | |
| S358 | VLASLsDDEDE | CK2a1 | RegPhos |
| T409 | GEKSAtPSRKI | Sigma70_ner; Plasmodium_V | PhosphoSitePlus |
| S478 | FLKVSsVFKDE | Plasmodium_Vir; RRN3; Ycf | PhosphoSitePlus |
| S453 | RLGPKsSVLIA | Plasmodium_Vir; CDC45; RR | PhosphoSitePlus |
| S358 | VLASLsDDEDE | phosphoELM | |
| S442 | FLAFPsPEKLL | HPRD; phosphoELM; RegPhos; SysPTM | |
| T485 | FKDEAtVRMAV | HPRD | |
| T485 | FKDEAtVRMAV | Plasmodium_Vir; RRN3; Ycf | PhosphoSitePlus |
| S478 | FLKVSsVFKDE | HPRD | |
| T436 | PADVStFLAFP | HPRD; phosphoELM; RegPhos | |
| S428 | APVLSsPPPAD | Plasmodium_Vir; CPSF100_C | PhosphoSitePlus |
| S29 | SFKGKsLKLNT | PhosphoSitePlus | |
| S428 | APVLSsPPPAD | HPRD; phosphoELM; RegPhos | |
| S427 | PAPVLsSPPPA | Plasmodium_Vir; CPSF100_C | PhosphoSitePlus |
| Y585 | LLQTLyKV___ | RanGAP1_C | PhosphoSitePlus |
| S24 | AGGQLsFKGKS | HPRD | |
| S435 | PPADVsTFLAF | Plasmodium_Vir; Drc1-Sld2 | PhosphoSitePlus |
| T409 | GEKSAtPSRKI | CDK1 | phosphoELM |
| S442 | FLAFPsPEKLL | Plasmodium_Vir; CDC45; RR | PhosphoSitePlus; SysPTM |
| S358 | VLASLsDDEDE | CSNK2A1 | HPRD |
| S427 | PAPVLsSPPPA | HPRD; phosphoELM | |
| S358 | VLASLsDDEDE | CK2a1-rs | RegPhos |
| Dephosphorylation site |
| RAGP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000348577 | E391K | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000401470 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| RAGP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | RAGP1_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | RAGP1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03013 | RNA transport |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032853 | positive regulation of Ran GTPase activity | TAS | biological_process |
| GO:0031965 | nuclear membrane | IEA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0000922 | spindle pole | IEA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
| GO:0046826 | negative regulation of protein export from nucleus | IDA | biological_process |
| GO:0000776 | kinetochore | IDA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0000777 | condensed chromosome kinetochore | IEA | cellular_component |
| GO:0005098 | Ran GTPase activator activity | IEA | molecular_function |
| GO:0005643 | nuclear pore | TAS | cellular_component |