| UniProt/SwissProt ID: | TF2AY_HUMAN |
| Description: | general transcription factor IIA, 1-like [Source:HGNC Symbol;Acc:30727] |
| Location: | chr2 p16.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S357 | SGDTSsNEEIG | CK2a2 | RegPhos |
| S418 | EDPLNsGDDVS | CK2a1 | RegPhos |
| S356 | GSGDTsSNEEI | CK2a2 | RegPhos |
| S356 | GSGDTsSNEEI | CK2a1 | RegPhos |
| S356 | GSGDTsSNEEI | CSNK2A1 | HPRD |
| S356 | GSGDTsSNEEI | CK2a1-rs | RegPhos |
| S423 | SGDDVsEQDVP | CSNK2A1 | HPRD |
| S423 | SGDDVsEQDVP | CK2a2 | RegPhos |
| S423 | SGDDVsEQDVP | CK2a1 | RegPhos |
| S418 | EDPLNsGDDVS | CK2a2 | RegPhos |
| S357 | SGDTSsNEEIG | CK2a1 | RegPhos |
| S418 | EDPLNsGDDVS | CK2_group | phosphoELM; RegPhos |
| S356 | GSGDTsSNEEI | CK2_group | phosphoELM; RegPhos |
| S423 | SGDDVsEQDVP | CSNK2A2 | HPRD |
| S418 | EDPLNsGDDVS | CK2a1-rs | RegPhos |
| S423 | SGDDVsEQDVP | CK2a1-rs | RegPhos |
| S357 | SGDTSsNEEIG | CK2a1-rs | RegPhos |
| S356 | GSGDTsSNEEI | CSNK2A2 | HPRD |
| S357 | SGDTSsNEEIG | CSNK2A1 | HPRD |
| S357 | SGDTSsNEEIG | CSNK2A2 | HPRD |
| S418 | EDPLNsGDDVS | CSNK2A1 | HPRD |
| S418 | EDPLNsGDDVS | CSNK2A2 | HPRD |
| S423 | SGDDVsEQDVP | CK2_group | phosphoELM; RegPhos |
| S357 | SGDTSsNEEIG | CK2_group | phosphoELM; RegPhos |
| Dephosphorylation site |
| TF2AY_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000384597 | D389G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000387896 | D355G | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TF2AY_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TF2AY_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK22_HUMAN | TF2AY_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | TF2AY_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05203 | Viral carcinogenesis |
| hsa03022 | Basal transcription factors |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005672 | transcription factor TFIIA complex | IEA | cellular_component |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0006367 | transcription initiation from RNA polymerase II pr | IEA | biological_process |