| UniProt/SwissProt ID: | IF5_HUMAN |
| Description: | eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:3299] |
| Location: | chr14 q32.32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S389 | EAEEEsSGGEE | CSNK2A1 | HPRD; SysPTM |
| Y16 | DQFYRyKMPRL | eIF-5_eIF-2B | PhosphoSitePlus |
| S390 | AEEESsGGEEE | CK2_alpha | phosphoELM |
| S10 | VNRSVsDQFYR | HPRD; phosphoELM; SysPTM | |
| S174 | ENGSVsSSETP | CK2a1-rs | RegPhos |
| Y16 | DQFYRyKMPRL | HPRD | |
| S390 | AEEESsGGEEE | CK2a1(CK2 alpha | RegPhos |
| T208 | WGEDTtEEAQR | PhosphoSitePlus | |
| S390 | AEEESsGGEEE | CSNK2B | HPRD |
| S389 | EAEEEsSGGEE | CK2a1(CK2 alpha | RegPhos; SysPTM |
| S174 | ENGSVsSSETP | P67870(Casein kinase II ) | RegPhos |
| S389 | EAEEEsSGGEE | CK2_alpha | phosphoELM; SysPTM |
| S389 | EAEEEsSGGEE | CK2a1 | RegPhos; SysPTM |
| S176 | GSVSSsETPPP | PhosphoSitePlus | |
| S389 | EAEEEsSGGEE | W2 | PhosphoSitePlus; SysPTM |
| S149 | NPPENsDSGTG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S390 | AEEESsGGEEE | phosphoELM; RegPhos | |
| S390 | AEEESsGGEEE | P67870(Casein kinase II ) | RegPhos |
| S174 | ENGSVsSSETP | CK2a1 | RegPhos |
| S406 | IEVVYsKAASV | PhosphoSitePlus | |
| S10 | VNRSVsDQFYR | eIF-5_eIF-2B | PhosphoSitePlus; SysPTM |
| S389 | EAEEEsSGGEE | CSNK2B | HPRD; SysPTM |
| S229 | KVLTLsDDLER | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S390 | AEEESsGGEEE | CK2a1 | RegPhos |
| Y405 | NIEVVySKAAS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| Y362 | KASKKyVSKEL | W2 | PhosphoSitePlus |
| S174 | ENGSVsSSETP | CSNK2A1 | HPRD |
| T227 | HAKVLtLSDDL | PhosphoSitePlus; HPRD; SysPTM | |
| S390 | AEEESsGGEEE | CK2a1-rs | RegPhos |
| S419 | VETVKsDNKDD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S389 | EAEEEsSGGEE | phosphoELM; RegPhos; SysPTM | |
| S175 | NGSVSsSETPP | PhosphoSitePlus | |
| T207 | DWGEDtTEEAQ | PhosphoSitePlus | |
| S390 | AEEESsGGEEE | CSNK2A1 | HPRD |
| S390 | AEEESsGGEEE | W2 | PhosphoSitePlus |
| S389 | EAEEEsSGGEE | CK2a1-rs | RegPhos; SysPTM |
| S410 | YSKAAsVPKVE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S174 | ENGSVsSSETP | CSNK2B | HPRD |
| S389 | EAEEEsSGGEE | P67870(Casein kinase II ) | RegPhos; SysPTM |
| Dephosphorylation site |
| IF5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376477 | M195V | COSMIC | Pancreatic Cancer | ENSP00000376477 | K418M | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000216554 | K418M | Sjoblom2006, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000376477 | Breast Cancer | Treatment (tamoxifen-sensitive vs. tamoxifen-resistant) | tissue | Up | 2 | 19329653 |
| Hyperphosphorylation site |
| IF5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | IF5_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| CSK2B_HUMAN | IF5_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | IF5_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03013 | RNA transport |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008135 | translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0005829 | cytosol | NAS | cellular_component |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0006412 | translation | TAS | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0006413 | translational initiation | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0003743 | translation initiation factor activity | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | IEA | biological_process |
| GO:0006446 | regulation of translational initiation | TAS | biological_process |
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |