Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M4K2_HUMAN
Description:mitogen-activated protein kinase kinase kinase kinase 2 [Source:HGNC Symbol;Acc:6864]
Location:chr11 q13.1
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S39RDTVTsELAAVHPRD
S8LLRDVsLQDPRPhosphoSitePlus
T326GPAERtPSEIQPhosphoSitePlus
T819TGHQStY____PhosphoSitePlus
S298HLGTPsPEDCEPhosphoSitePlus
T578PTNRLtQRIIPCNHPhosphoSitePlus
S328AERTPsEIQFHPhosphoSitePlus
S327AERTPsEIQFHphosphoELM
Y27VGAGTyGDVYKPkinasePhosphoSitePlus
S170VAKRRsFIGTPPkinasePhosphoSitePlus
S394FQELDsPDDTMPhosphoSitePlus; HPRD
S227ALMLMsKSSFQPkinasePhosphoSitePlus
T574PLSIPtNRLTQCNHPhosphoSitePlus
Y307CELETyDMFPDPhosphoSitePlus
T306DCELEtYDMFPPhosphoSitePlus

Dephosphorylation site
M4K2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000294066L522VCOSMICGastric Cancer21097718
ENSP00000294066F640LBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
M4K2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M4K2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M4K2_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANM4K2_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANM4K2_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANUBTD2_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANGDIB_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
TRAF2_HUMANM4K2_HUMANotherKEGG
SRBP1_HUMANM4K2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0007257activation of JUN kinase activityIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046330positive regulation of JNK cascadeIDAbiological_process
GO:0006955immune responseTASbiological_process
GO:0006903vesicle targetingNASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0006903vesicle targetingIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0006950response to stressTASbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0031435mitogen-activated protein kinase kinase kinase binIPImolecular_function
GO:0045087innate immune responseIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000139Golgi membraneIEAcellular_component
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0007254JNK cascadeTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23