| UniProt/SwissProt ID: | MYB_HUMAN |
| Description: | v-myb myeloblastosis viral oncogene homolog (avian) [Source:HGNC Symbol;Acc:7545] |
| Location: | chr6 q23.3 |
| Node attribute: | gene; substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S11 | RHSIYsSDEDD | CK2_alpha | phosphoELM |
| T420 | EMPSLtSTPLI | Cmyb_C | PhosphoSitePlus |
| T534 | EVESPtDKSGN | Cmyb_C | PhosphoSitePlus |
| S463 | SILESsPRTPT | Cmyb_C | PhosphoSitePlus |
| S12 | HSIYSsDEDDE | CK2a1-rs | RegPhos |
| S11 | RHSIYsSDEDD | CK2a1-rs | RegPhos |
| S11 | RHSIYsSDEDD | CK2_group | phosphoELM; RegPhos |
| S12 | HSIYSsDEDDE | CK2_alpha | phosphoELM |
| T433 | KLTVTtPFHRD | Cmyb_C | PhosphoSitePlus |
| T466 | ESSPRtPTPFK | Cmyb_C | PhosphoSitePlus |
| Y69 | KVIANyLPNRT | Myb_DNA-bind_6 | PhosphoSitePlus |
| S532 | KQEVEsPTDKS | Erk2 | RegPhos |
| S532 | KQEVEsPTDKS | Cmyb_C | PhosphoSitePlus |
| S11 | RHSIYsSDEDD | CSNK2A1 | HPRD |
| S11 | RHSIYsSDEDD | CK2a1 | RegPhos |
| S12 | HSIYSsDEDDE | CSNK2A1 | HPRD |
| S12 | HSIYSsDEDDE | CK2a1 | RegPhos |
| S532 | KQEVEsPTDKS | MAPK_group | phosphoELM; RegPhos |
| S12 | HSIYSsDEDDE | CK2a1(CK2 alpha | RegPhos |
| S12 | HSIYSsDEDDE | CK2_group | phosphoELM; RegPhos |
| S11 | RHSIYsSDEDD | PhosphoSitePlus | |
| S532 | KQEVEsPTDKS | MAPK1 | HPRD |
| S532 | KQEVEsPTDKS | MAPK3 | phosphoELM |
| S11 | RHSIYsSDEDD | CK2a1(CK2 alpha | RegPhos |
| S12 | HSIYSsDEDDE | PhosphoSitePlus | |
| S532 | KQEVEsPTDKS | Erk1(MAPK3 | RegPhos |
| Dephosphorylation site |
| MYB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339992 | E201* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000410825 | E514Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356788 | D334N | COSMIC | Skin Cancer | 21984974 | ENSP00000356786 | *667Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356788 | E201* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000410825 | E201* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356788 | E514Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356788 | C130Y | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000339992 | E437* | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| MYB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MYB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | MYB_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | MYB_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK03_HUMAN | MYB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MZF1_HUMAN | MYB_HUMAN | TF -> target gene | TRANSFAC |
| MYB_HUMAN | CDK1_HUMAN | TF -> target gene | TRANSFAC |
| MYB_HUMAN | MYB_HUMAN | TF -> target gene | TRANSFAC |
| MYB_HUMAN | KIT_HUMAN | TF -> target gene | TRANSFAC |
| MYB_HUMAN | SRSF2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:0051574 | positive regulation of histone H3-K9 methylation | IMP | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IMP | biological_process |
| GO:0048566 | embryonic digestive tract development | IEA | biological_process |
| GO:0048538 | thymus development | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045624 | positive regulation of T-helper cell differentiati | IMP | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006338 | chromatin remodeling | IMP | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0016363 | nuclear matrix | NAS | cellular_component |
| GO:0051571 | positive regulation of histone H3-K4 methylation | IMP | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0010468 | regulation of gene expression | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0048872 | homeostasis of number of cells | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |