Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FAF1_HUMAN
Description:Fas (TNFRSF6) associated factor 1 [Source:HGNC Symbol;Acc:3578]
Location:chr1 p32.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S270VGRRSsPAQTRPhosphoSitePlus; HPRD
S289DVHMVsDSDGDCK2a1-rsRegPhos
S342FTAEFsSRYGDPhosphoSitePlus
S291HMVSDsDGDDFCK2_groupphosphoELM; RegPhos
S289DVHMVsDSDGDCK2_groupphosphoELM; RegPhos
S291HMVSDsDGDDFCK2a1RegPhos
Y225VKRNVyDLTSIHPRD; RegPhos
Y225VKRNVyDLTSIubiquitinPhosphoSitePlus
S291HMVSDsDGDDFCK2a1(CK2 alphaRegPhos
S291HMVSDsDGDDFCK2a1-rsRegPhos
S320SALRKsPMMPEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S582RIRTPsGEFLEUBXPhosphoSitePlus
S153GDVEDsTVLKSHPRD
S291HMVSDsDGDDFCK2_alphaphosphoELM
S289DVHMVsDSDGDCK2a1RegPhos
S343TAEFSsRYGDCPhosphoSitePlus
T580KLRIRtPSGEFUBXPhosphoSitePlus
S289DVHMVsDSDGDCSNK2A1HPRD
S582RIRTPsGEFLEHPRD
T274SSPAQtREQSEPhosphoSitePlus; HPRD
S291HMVSDsDGDDFCSNK2A1HPRD
S289DVHMVsDSDGDPhosphoSitePlus
S291HMVSDsDGDDFPhosphoSitePlus
S289DVHMVsDSDGDCK2_alphaphosphoELM
S289DVHMVsDSDGDCK2a1(CK2 alphaRegPhos

Dephosphorylation site
FAF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379457P89SCOSMICPancreatic Cancer
ENSP00000360843P89SCOSMICPancreatic Cancer
ENSP00000379457F602SCOSMICHead and Neck Cancer21798893
ENSP00000360843F602SCOSMICHead and Neck Cancer21798893

Differential expressed protein
FAF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FAF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANFAF1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANFAF1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
FAF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051059NF-kappaB bindingIPImolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0043161proteasomal ubiquitin-dependent protein catabolic NASbiological_process
GO:0031072heat shock protein bindingIDAmolecular_function
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0008219cell deathIMPbiological_process
GO:0031334positive regulation of protein complex assemblyIMPbiological_process
GO:0042176regulation of protein catabolic processIMPbiological_process
GO:0019901protein kinase bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0045859regulation of protein kinase activityNASbiological_process
GO:0043130ubiquitin bindingIDAmolecular_function
GO:0031625ubiquitin protein ligase bindingIDAmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005635nuclear envelopeIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0007253cytoplasmic sequestering of NF-kappaBIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0034098Cdc48p-Npl4p-Ufd1p AAA ATPase complexIDAcellular_component
GO:0031265CD95 death-inducing signaling complexNAScellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0019887protein kinase regulator activityNASmolecular_function
GO:0043065positive regulation of apoptotic processNASbiological_process


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