Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZAP70_HUMAN
Description:zeta-chain (TCR) associated protein kinase 70kDa [Source:HGNC Symbol;Acc:12858]
Location:chr2 q11.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y204ALSLIyGKTVYSH2PhosphoSitePlus
Y569CPPELyALMSDPkinase_TyrPhosphoSitePlus
Y474LVNRHyAKISDPkinase_TyrPhosphoSitePlus
Y12VYESPySDPEEZAP70HPRD
T494DDSYYtARSAGHPRD; RegPhos
T293NSDGYtPEPARPhosphoSitePlus; HPRD; RegPhos
T300EPARItSPDKPPhosphoSitePlus
Y126AMVRDyVRQTWZAP70HPRD; phosphoELM; RegPhos
Y493ADDSYyTARSAZAP70phosphoELM; RegPhos; SysPTM
T312PMPMDtSVYESPhosphoSitePlus
Y397QLDNPyIVRLIPkinase_TyrPhosphoSitePlus
Y493ADDSYyTARSALCKHPRD; RegPhos; SysPTM
Y12HLPFFyGSISRSH2PhosphoSitePlus
Y319VYESPySDPEEZAP70HPRD; RegPhos
T187DDSYYtARSAGHPRD
Y186ADDSYyTARSALCKHPRD
Y69QLNGTyAIAGGSH2PhosphoSitePlus
Y319VYESPySDPEELCKHPRD; RegPhos
Y493ADDSYyTARSAphosphoELM; RegPhos; SysPTM
Y12HLPFFyGSISRZAP70RegPhos
Y492GADDSyYTARSLckphosphoELM; RegPhos
Y492GADDSyYTARSphosphoELM
S317TSVYEsPYSDPPhosphoSitePlus
S534MWEALsYGQKPPkinase_TyrPhosphoSitePlus
Y474LVNRHyAKISDLckphosphoELM; RegPhos
Y315MDTSVyESPYSPhosphoSitePlus; phosphoELM; RegPhos
Y315MDTSVyESPYSZAP70HPRD; phosphoELM; RegPhos
Y597RMRACyYSLASPhosphoSitePlus
S258ACPNSsASNASPhosphoSitePlus
Y474LVNRHyAKISDP29353(SHC (Src homology RegPhos
Y492GADDSyYTARSautocatalysisRegPhos
Y178AERKLySGAQTLCKHPRD; RegPhos
T611GPPGStQKAEAPhosphoSitePlus
S599RACYYsLASKVPhosphoSitePlus
Y211KTVYHyLISQDSH2PhosphoSitePlus
S179ERKLYsGAQTDSH2PhosphoSitePlus
S289IDTLNsDGYTPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y12HLPFFyGSISRLCKRegPhos
S167PWYHSsLTREESH2PhosphoSitePlus
Y493ADDSYyTARSAPkinase_TyrPhosphoSitePlus; SysPTM
Y292LNSDGyTPEPAZAP70HPRD; phosphoELM; RegPhos; SysPTM
Y492GADDSyYTARSZAP70phosphoELM; RegPhos
S520KFSSRsDVWSYPkinase_TyrPhosphoSitePlus
Y319VYESPySDPEEPhosphoSitePlus; phosphoELM; RegPhos
Y209YGKTVyHYLISSH2PhosphoSitePlus
Y164ERMPWyHSSLTSH2PhosphoSitePlus
T278HPSTLtHPQRRPhosphoSitePlus
S166MPWYHsSLTRESH2PhosphoSitePlus
Y167LVNRHyAKISDSHC1HPRD
S351CGNFGsVRQGVPkinase_TyrPhosphoSitePlus
Y8MDTSVyESPYSZAP70HPRD
Y598MRACYySLASKPhosphoSitePlus
Y506WPLKWyAPECIPkinase_TyrPhosphoSitePlus
Y474LVNRHyAKISDLCKHPRD; RegPhos
Y492GADDSyYTARSLCKHPRD; RegPhos
S257EACPNsSASNAPhosphoSitePlus
S320YESPYsDPEELPhosphoSitePlus
Y248ADGLIyCLKEAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T197RKEQGtYALSLSH2PhosphoSitePlus
S491LGADDsYYTARPkinase_TyrPhosphoSitePlus
Y292LNSDGyTPEPAPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S313MPMDTsVYESPPhosphoSitePlus
Y535WEALSyGQKPYPkinase_TyrPhosphoSitePlus
Y12VYESPySDPEELCKHPRD
Y167LVNRHyAKISDLCKHPRD
Y126AMVRDyVRQTWPhosphoSitePlus
Y221DKAGKyCIPEGSH2PhosphoSitePlus
Y493ADDSYyTARSALckphosphoELM; RegPhos; SysPTM
Y292LNSDGyTPEPALckphosphoELM; RegPhos; SysPTM
Y69QLNGTyAIAGGLCKHPRD; RegPhos
Y178AERKLySGAQTSH2PhosphoSitePlus
S263SASNAsGAAAPPhosphoSitePlus
Y185GADDSyYTARSLCKHPRD
T494DDSYYtARSAGPkinase_TyrPhosphoSitePlus
Y87ELCEFySRDPDSH2PhosphoSitePlus
S301PARITsPDKPRPhosphoSitePlus
Y198KEQGTyALSLISH2PhosphoSitePlus
T286QRRIDtLNSDGPhosphoSitePlus
Y46RSLGGyVLSLVSH2PhosphoSitePlus
Y492GADDSyYTARSPkinase_TyrPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y292DTLNSDGyTPEPARIACP1HPRD
Y493LGADDSYyTARSAGKPTPN22HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264972G448EGreenman2007, HPIHead and Neck Cancer17344846, 18428421
ENSP00000264972*620YCOSMICIntestines Cancer16959974
ENSP00000264972A495VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000264972D303GTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
ZAP70_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZAP70_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAP70_HUMANEPHB3_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANZAP70_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
ZAP70_HUMANLAT_HUMANkinase -> substrateRegPhos; NetPath
ZAP70_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANLAX1_HUMANkinase -> substrateNetPath
ZAP70_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANSH2B3_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
ZAP70_HUMANMUC1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
ZAP70_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANTRAT1_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANZAP70_HUMANkinase -> substrateRegPhos
ZAP70_HUMANSHC1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
PAK4_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
SHC1_HUMANZAP70_HUMANkinase -> substrateHPRD
ZAP70_HUMANLCP2_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
ZAP70_HUMANZAP70_HUMANkinase -> substrateRegPhos; NetPath
MK14_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANMK14_HUMANkinase -> substrateKEGG; RegPhos; Robert H Newman (2013)
M3K7_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
KCC1B_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
KPCL_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANDUS3_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
CSK21_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANGAB2_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
ZAP70_HUMANDBNL_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
ZAP70_HUMANVAV_HUMANkinase -> substrateNetPath
PDPK1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANNFAM1_HUMANkinase -> substrateNetPath
ZAP70_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
PTN6_HUMANZAP70_HUMANphosphatase -> substrateKEGG
PTN22_HUMANZAP70_HUMANphosphatase -> substrateHPRD
PPAC_HUMANZAP70_HUMANphosphatase -> substrateHPRD; NetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa05340Primary immunodeficiency
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043366beta selectionIEAbiological_process
GO:0005524ATP bindingNASmolecular_function
GO:0042113B cell activationTASbiological_process
GO:0046638positive regulation of alpha-beta T cell differentIEAbiological_process
GO:0007243intracellular protein kinase cascadeNASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0050850positive regulation of calcium-mediated signalingIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005737cytoplasmTAScellular_component
GO:0045059positive thymic T cell selectionIEAbiological_process
GO:0042110T cell activationTASbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0002250adaptive immune responseTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiTASmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0045061thymic T cell selectionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006955immune responseIDAbiological_process
GO:0042101T cell receptor complexIDAcellular_component
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0001772immunological synapseIEAcellular_component
GO:0046641positive regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0045582positive regulation of T cell differentiationIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0072678T cell migrationTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0030217T cell differentiationNASbiological_process
GO:0070489T cell aggregationTASbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0045582positive regulation of T cell differentiationIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0001784phosphotyrosine bindingIEAmolecular_function
GO:0045059positive thymic T cell selectionIDAbiological_process