Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CREM_HUMAN
Description:cAMP responsive element modulator [Source:HGNC Symbol;Acc:2352]
Location:chr10 p11.21
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S178AASPGsLHSPQHPRD
S130LNELSsDVPGVRegPhos
S87LSRRPsYRKILCAMK2GHPRD
T96AAIAEtDESAECK2a1RegPhos
S274AASPGsLHSPQphosphoELM
S110IEEERsEEEGTCSNK2A2HPRD
S143IEEERsEEEGTCK1aRegPhos
S97LNELSsDVPGVHPRD
S143IEEERsEEEGTCK2a1-rsRegPhos
S177PGSLHsPQQLAHPRD
S271VVMAAsPGSLHphosphoELM
S66AETDEsAESEGCSNK1A1HPRD
S41PGSLHsPQQLAHPRD
T96AAIAEtDESAECK2a2RegPhos
S67RREILsRRPSYHPRD
T190LAEEAtRKRELHPRD
S120LSRRPsYRKILRegPhos
S35VVMAAsPGSLHHPRD
S143IEEERsEEEGTCK2a1RegPhos
S83RREILsRRPSYHPRD
S32AASPGsLHSPQHPRD
T96AAIAEtDESAERegPhos
S53PGSLHsPQQLAHPRD
S120LSRRPsYRKILPKCaRegPhos
S36AETDEsAESEGCSNK1A1HPRD
S110IEEERsEEEGTCSNK2A1HPRD
S175VVMAAsPGSLHHPRD
S136AASPGsLHSPQHPRD
S290AASPGsLHSPQbZIP_1PhosphoSitePlus
S120LSRRPsYRKILCDC2RegPhos
T148LAEEAtRKRELHPRD
S83WVIQSsEIHTVGSK3ARegPhos
S83WVIQSsEIHTVGSK3BRegPhos
S181PGSLHsPQQLAHPRD
Y137SRRPSyRKILNpKIDPhosphoSitePlus
S80ILNELsSDVPGHPRD
S229AASPGsLHSPQHPRD
S38AASPGsLHSPQHPRD
S129ILNELsSDVPGRegPhos
S108EGVIDsHKRRERegPhos
S42ALAQVsVAGSGRegPhos
T62LAEEAtRKRELHPRD
S110IEEERsEEEGTCDK1HPRD
S35PGSLHsPQQLAHPRD
S116RREILsRRPSYphosphoELM; RegPhos
T63AAIAEtDESAEHPRD
S47VVMAAsPGSLHHPRD
S71LSRRPsYRKILHPRD
S29VVMAAsPGSLHHPRD
S67LNELSsDVPGVHPRD
S83RREILsRRPSYGSK3BHPRD
S83RREILsRRPSYGSK3AHPRD
S99AETDEsAESEGCK1aRegPhos
S87LSRRPsYRKILCDK1HPRD
T186LAEEAtRKRELHPRD
S143IEEERsEEEGTRegPhos
S53RREILsRRPSYHPRD
T96AAIAEtDESAECK2a1-rsRegPhos
S139PGSLHsPQQLAHPRD
S87LSRRPsYRKILPRKACAHPRD
S87LSRRPsYRKILPRKCAHPRD
S226VVMAAsPGSLHHPRD
S171VVMAAsPGSLHHPRD
S87LSRRPsYRKILHPRD
S287VVMAAsPGSLHbZIP_1PhosphoSitePlus
T44LAEEAtRKRELHPRD
S50AASPGsLHSPQHPRD
S87LSRRPsYRKILCAMK2DHPRD
S75EGVIDsHKRREHPRD
S120LSRRPsYRKILPKACaRegPhos
S83WVIQSsEIHTVRegPhos
S57LSRRPsYRKILHPRD
T275QIRAPtAALPQPhosphoSitePlus
S120LSRRPsYRKILCaMK2gRegPhos
S133VVMAAsPGSLHHPRD
T8AAIAEtDESAEHPRD
S81LNELSsDVPGVHPRD
S143IEEERsEEEGTCDC2RegPhos
T47AAIAEtDESAEHPRD
S66ILNELsSDVPGHPRD
T286LAEEAtRKRELphosphoELM
S110IEEERsEEEGTHPRD
S80IEEERsEEEGTHPRD
S202PGSLHsPQQLAHPRD
S120LSRRPsYRKILCaMK2dRegPhos
S45EGVIDsHKRREHPRD
S110IEEERsEEEGTCSNK1A1HPRD
S232PGSLHsPQQLAHPRD
T211LAEEAtRKRELHPRD
S94IEEERsEEEGTHPRD
T241LAEEAtRKRELHPRD
T63AAIAEtDESAECSNK2A1HPRD
T63AAIAEtDESAECSNK2A2HPRD
T50LAEEAtRKRELHPRD
S96ILNELsSDVPGHPRD
S293PGSLHsPQQLAbZIP_1PhosphoSitePlus
T33AAIAEtDESAEHPRD
S277PGSLHsPQQLAphosphoELM
S196VVMAAsPGSLHHPRD
S199AASPGsLHSPQHPRD
S174AASPGsLHSPQHPRD
S50AETDEsAESEGCSNK1A1HPRD
S136LSRRPsYRKILpKIDPhosphoSitePlus
S143IEEERsEEEGTCK2a2RegPhos

Dephosphorylation site
CREM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265372R242CBIOMARTBreast Cancer21930507, 21930502
ENSP00000354593R212CBIOMARTBreast Cancer21930507, 21930502
ENSP00000379225R224CBIOMARTBreast Cancer21930507, 21930502
ENSP00000379225E16GCOSMICHepatocellular Carcinoma
ENSP00000420511R254CBIOMARTBreast Cancer21930507, 21930502
ENSP00000341875R187CBIOMARTBreast Cancer21930507, 21930502
ENSP00000349387R51CBIOMARTBreast Cancer21930507, 21930502
ENSP00000420681R63CBIOMARTBreast Cancer21930507, 21930502
ENSP00000417460R51CBIOMARTBreast Cancer21930507, 21930502
ENSP00000417562R55CBIOMARTBreast Cancer21930507, 21930502
ENSP00000417807R63CBIOMARTBreast Cancer21930507, 21930502
ENSP00000363854R275CBIOMARTBreast Cancer21930507, 21930502
ENSP00000419075R45CBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CREM_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CREM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCREM_HUMANkinase -> substrateRegPhos
KCC2G_HUMANCREM_HUMANkinase -> substrateHPRD
CDK1_HUMANCREM_HUMANkinase -> substrateRegPhos
CSK22_HUMANCREM_HUMANkinase -> substrateHPRD
CSK21_HUMANCREM_HUMANkinase -> substrateHPRD
KCC2D_HUMANCREM_HUMANkinase -> substrateHPRD
GSK3B_HUMANCREM_HUMANkinase -> substrateHPRD; RegPhos
KC1A_HUMANCREM_HUMANkinase -> substrateHPRD
KPCA_HUMANCREM_HUMANkinase -> substrateHPRD
GSK3A_HUMANCREM_HUMANkinase -> substrateHPRD; RegPhos
CREM_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
CREM_HUMANCCND1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CREM_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008140cAMP response element binding protein bindingNASmolecular_function
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006687glycosphingolipid metabolic processIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005634nucleusNAScellular_component
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component