| UniProt/SwissProt ID: | RGS19_HUMAN |
| Description: | regulator of G-protein signaling 19 [Source:HGNC Symbol;Acc:13735] |
| Location: | chr20 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S214 | GPSQSsSEA__ | PhosphoSitePlus; SysPTM | |
| S24 | RPPSMsSHDTA | PKC_group | RegPhos |
| S213 | QGPSQsSSEA_ | PhosphoSitePlus; SysPTM | |
| S148 | YEDYVsILSPK | RGS | PhosphoSitePlus |
| S214 | GPSQSsS | HPRD; SysPTM | |
| Y146 | LIYEDyVSILS | RGS | PhosphoSitePlus |
| S215 | PSQSSs | HPRD; SysPTM | |
| S97 | DKLMHsPAGRS | HPRD; SysPTM | |
| S24 | RPPSMsSHDTA | CK2a2 | RegPhos |
| S213 | QGPSQsSS | HPRD; SysPTM | |
| S151 | YVSILsPKEVS | Erk1(MAPK3 | RegPhos |
| S97 | DKLMHsPAGRS | RGS | PhosphoSitePlus; SysPTM |
| S24 | RPPSMsSHDTA | CK2_group | phosphoELM; RegPhos |
| T201 | FLSSPtYRALL | RGS | PhosphoSitePlus |
| S211 | LLQGPsQSSSE | PhosphoSitePlus | |
| S24 | RPPSMsSHDTA | PKCa | RegPhos |
| T201 | FLSSPtYRALL | PKC_group | phosphoELM; RegPhos |
| S199 | PRFLSsPTYRA | RGS | PhosphoSitePlus |
| S151 | YVSILsPKEVS | RGS | PhosphoSitePlus |
| S151 | YVSILsPKEVS | Erk2 | RegPhos |
| Y202 | LSSPTyRALLL | RGS | PhosphoSitePlus |
| S151 | YVSILsPKEVS | MAPK1 | HPRD; phosphoELM |
| S24 | RPPSMsSHDTA | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y143 | KARLIyEDYVS | RGS | PhosphoSitePlus |
| S24 | RPPSMsSHDTA | CK2a1 | RegPhos |
| S151 | YVSILsPKEVS | CK2_group | phosphoELM; RegPhos |
| T201 | FLSSPtYRALL | PRKCA | HPRD |
| S151 | YVSILsPKEVS | Erk2(MAPK1 | RegPhos |
| T201 | FLSSPtYRALL | PKCa | RegPhos |
| S24 | RPPSMsSHDTA | CSNK2A2 | HPRD |
| S24 | RPPSMsSHDTA | CSNK2A1 | HPRD |
| S215 | PSQSSsEA___ | PhosphoSitePlus; SysPTM | |
| S24 | RPPSMsSHDTA | PRKCA | HPRD |
| S24 | RPPSMsSHDTA | CK2a1-rs | RegPhos |
| Dephosphorylation site |
| RGS19_HUMAN do not have dephosphorylation site. |
| Mutation site |
| RGS19_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000378483 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| RGS19_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | RGS19_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCA_HUMAN | RGS19_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | RGS19_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | RGS19_HUMAN | kinase -> substrate | RegPhos |
| CSK22_HUMAN | RGS19_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| RGS19_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | IBA | cellular_component |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0005096 | GTPase activator activity | IBA | molecular_function |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006914 | autophagy | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0044445 | cytosolic part | IEA | cellular_component |
| GO:0043547 | positive regulation of GTPase activity | IBA | biological_process |
| GO:0001965 | G-protein alpha-subunit binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IBA | cellular_component |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030136 | clathrin-coated vesicle | IEA | cellular_component |
| GO:0005834 | heterotrimeric G-protein complex | TAS | cellular_component |
| GO:0005903 | brush border | IEA | cellular_component |