Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ATF1_HUMAN
Description:activating transcription factor 1 [Source:HGNC Symbol;Acc:783]
Location:chr12 q13.12
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S63LARRPsYRKILMSK1(RSK5RegPhos
S63LARRPsYRKILRPS6KA4HPRD
S63LARRPsYRKILphosphoELM
S36QVSSLsESEESPhosphoSitePlus; phosphoELM
S36QVSSLsESEESCK2a1RegPhos
S63LARRPsYRKILCDK3phosphoELM
S47QDSSDsIGSSQHPRD
S63LARRPsYRKILPKACaRegPhos
S63LARRPsYRKILpKIDPhosphoSitePlus
S36QVSSLsESEESCK2_groupphosphoELM; RegPhos
S36QVSSLsESEESCK2a1-rsRegPhos
S63LARRPsYRKILCaMK2gRegPhos
S63LARRPsYRKILCAMK1HPRD
S47QDSSDsIGSSQpKIDPhosphoSitePlus
S41SESEEsQDSSDPhosphoSitePlus
S51DSIGSsQKAHGpKIDPhosphoSitePlus
S63LARRPsYRKILCAMK2GHPRD
S63LARRPsYRKILMSK2RegPhos
T197QTVVMtSPVTLASD2PhosphoSitePlus
S50SDSIGsSQKAHpKIDPhosphoSitePlus
S63LARRPsYRKILRPS6KA5HPRD
S63LARRPsYRKILCaMK1 _groupRegPhos
S63LARRPsYRKILMSK1RegPhos
T188TTPSAtSLPQTHPRD; phosphoELM
T209SQTTKtDDPQLASD2PhosphoSitePlus
T183TYQIRtTPSATHPRD; phosphoELM
Y64ARRPSyRKILKpKIDPhosphoSitePlus
S198TVVMTsPVTLTHPRD; phosphoELM; SysPTM
S198TVVMTsPVTLTASD2PhosphoSitePlus; SysPTM
S186IRTTPsATSLPHPRD; phosphoELM
S63LARRPsYRKILPRKACAHPRD
T197QTVVMtSPVTLHPRD; phosphoELM
S63LARRPsYRKILCaMK1aRegPhos
S36QVSSLsESEESCSNK2A1HPRD

Dephosphorylation site
ATF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262053L71ICOSMICOvarian Cancer21720365
ENSP00000262053R228GCOSMICOvarian Cancer21720365
ENSP00000262053R228GTCGAOvarian Cancer21720365, 18772890
ENSP00000262053L71ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
ATF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ATF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A4_HUMANATF1_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANATF1_HUMANkinase -> substrateHPRD
KPCA_HUMANATF1_HUMANkinase -> substrateHPRD
KCC1A_HUMANATF1_HUMANkinase -> substrateHPRD
KS6A5_HUMANATF1_HUMANkinase -> substrateHPRD; RegPhos
KCC2G_HUMANATF1_HUMANkinase -> substrateHPRD
ATF1_HUMANC2TA_HUMANTF -> target geneTRANSFAC
ATF1_HUMANLORI_HUMANTF -> target geneTRANSFAC
ATF1_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
ATF1_HUMANEGR1_HUMANTF -> target geneTRANSFAC
ATF1_HUMANTGFB2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003677DNA bindingIEAmolecular_function
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0045087innate immune responseTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process


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