| UniProt/SwissProt ID: | ATF1_HUMAN |
| Description: | activating transcription factor 1 [Source:HGNC Symbol;Acc:783] |
| Location: | chr12 q13.12 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S63 | LARRPsYRKIL | MSK1(RSK5 | RegPhos |
| S63 | LARRPsYRKIL | RPS6KA4 | HPRD |
| S63 | LARRPsYRKIL | phosphoELM | |
| S36 | QVSSLsESEES | PhosphoSitePlus; phosphoELM | |
| S36 | QVSSLsESEES | CK2a1 | RegPhos |
| S63 | LARRPsYRKIL | CDK3 | phosphoELM |
| S47 | QDSSDsIGSSQ | HPRD | |
| S63 | LARRPsYRKIL | PKACa | RegPhos |
| S63 | LARRPsYRKIL | pKID | PhosphoSitePlus |
| S36 | QVSSLsESEES | CK2_group | phosphoELM; RegPhos |
| S36 | QVSSLsESEES | CK2a1-rs | RegPhos |
| S63 | LARRPsYRKIL | CaMK2g | RegPhos |
| S63 | LARRPsYRKIL | CAMK1 | HPRD |
| S47 | QDSSDsIGSSQ | pKID | PhosphoSitePlus |
| S41 | SESEEsQDSSD | PhosphoSitePlus | |
| S51 | DSIGSsQKAHG | pKID | PhosphoSitePlus |
| S63 | LARRPsYRKIL | CAMK2G | HPRD |
| S63 | LARRPsYRKIL | MSK2 | RegPhos |
| T197 | QTVVMtSPVTL | ASD2 | PhosphoSitePlus |
| S50 | SDSIGsSQKAH | pKID | PhosphoSitePlus |
| S63 | LARRPsYRKIL | RPS6KA5 | HPRD |
| S63 | LARRPsYRKIL | CaMK1 _group | RegPhos |
| S63 | LARRPsYRKIL | MSK1 | RegPhos |
| T188 | TTPSAtSLPQT | HPRD; phosphoELM | |
| T209 | SQTTKtDDPQL | ASD2 | PhosphoSitePlus |
| T183 | TYQIRtTPSAT | HPRD; phosphoELM | |
| Y64 | ARRPSyRKILK | pKID | PhosphoSitePlus |
| S198 | TVVMTsPVTLT | HPRD; phosphoELM; SysPTM | |
| S198 | TVVMTsPVTLT | ASD2 | PhosphoSitePlus; SysPTM |
| S186 | IRTTPsATSLP | HPRD; phosphoELM | |
| S63 | LARRPsYRKIL | PRKACA | HPRD |
| T197 | QTVVMtSPVTL | HPRD; phosphoELM | |
| S63 | LARRPsYRKIL | CaMK1a | RegPhos |
| S36 | QVSSLsESEES | CSNK2A1 | HPRD |
| Dephosphorylation site |
| ATF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262053 | L71I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000262053 | R228G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000262053 | R228G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000262053 | L71I | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| ATF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ATF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6A4_HUMAN | ATF1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| CSK21_HUMAN | ATF1_HUMAN | kinase -> substrate | HPRD |
| KPCA_HUMAN | ATF1_HUMAN | kinase -> substrate | HPRD |
| KCC1A_HUMAN | ATF1_HUMAN | kinase -> substrate | HPRD |
| KS6A5_HUMAN | ATF1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| KCC2G_HUMAN | ATF1_HUMAN | kinase -> substrate | HPRD |
| ATF1_HUMAN | C2TA_HUMAN | TF -> target gene | TRANSFAC |
| ATF1_HUMAN | LORI_HUMAN | TF -> target gene | TRANSFAC |
| ATF1_HUMAN | CCNA2_HUMAN | TF -> target gene | TRANSFAC |
| ATF1_HUMAN | EGR1_HUMAN | TF -> target gene | TRANSFAC |
| ATF1_HUMAN | TGFB2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathwa | TAS | biological_process |
| GO:0051403 | stress-activated MAPK cascade | TAS | biological_process |
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0002756 | MyD88-independent toll-like receptor signaling pat | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |