Phosphorylation

You are querying signaling transduction network mediated by FGFR1_HUMAN in Hepatocellular Carcinoma.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	FGF8_HUMAN	FGFR1_HUMAN	ligand -> receptor	HPMR
2	FGF3_HUMAN	FGFR1_HUMAN	ligand -> receptor	HPMR
3	FGF23_HUMAN	FGFR1_HUMAN	ligand -> receptor	HPMR
4	FGF5_HUMAN	FGFR1_HUMAN	ligand -> receptor	HPMR
5	FGF1_HUMAN	FGFR1_HUMAN	ligand -> receptor; other	HPMR; KEGG
6	FGF4_HUMAN	FGFR1_HUMAN	ligand -> receptor	HPMR
7	FGFR1_HUMAN	KS6A3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
8	FGFR1_HUMAN	RAGE_HUMAN	kinase -> substrate	Robert H Newman (2013)
9	KS6A3_HUMAN	FOS_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
10	RAGE_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
11	RAGE_HUMAN	CSK22_HUMAN	kinase -> substrate	Robert H Newman (2013)
12	KS6A3_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
13	KS6A3_HUMAN	P53_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
14	KS6A3_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
15	KS6A3_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
16	KS6A3_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD; RegPhos
17	RAGE_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
18	KS6A3_HUMAN	ATF4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
19	RAGE_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
20	FOS_HUMAN	MLTK_HUMAN	TF -> target gene	TRANSFAC
21	MK07_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
22	FOS_HUMAN	WEE1_HUMAN	TF -> target gene	TRANSFAC
23	CSK22_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
24	CSK22_HUMAN	PTN1_HUMAN	kinase -> substrate	HPRD
25	MK07_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
26	CSK22_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
27	CSK22_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
28	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
29	P53_HUMAN	ATF3_HUMAN	TF -> target gene	TRANSFAC
30	MK07_HUMAN	SGK1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
31	CSK22_HUMAN	E2AK2_HUMAN	kinase -> substrate	Robert H Newman (2013)
32	P53_HUMAN	DUS1_HUMAN	TF -> target gene	TRANSFAC
33	P53_HUMAN	P73_HUMAN	TF -> target gene	KEGG; TRANSFAC
34	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
35	MK07_HUMAN	ETS1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
36	CSK22_HUMAN	PTPRC_HUMAN	kinase -> substrate	HPRD
37	P53_HUMAN	P63_HUMAN	TF -> target gene	TRANSFAC
38	MK07_HUMAN	RIPK3_HUMAN	kinase -> substrate	Robert H Newman (2013)
39	CSK22_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD
40	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
41	STK11_HUMAN	AAPK2_HUMAN	kinase -> substrate	RegPhos
42	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
43	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
44	STK11_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
46	STK11_HUMAN	AAPK1_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
47	P53_HUMAN	CHK1_HUMAN	TF -> target gene	TRANSFAC
48	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
49	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
50	CSK22_HUMAN	MYC_HUMAN	kinase -> substrate	HPRD
51	CSK22_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	MK07_HUMAN	RXRA_HUMAN	kinase -> substrate	HPRD
53	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
54	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
55	P53_HUMAN	BBC3_HUMAN	TF -> target gene	TRANSFAC
56	P53_HUMAN	EGFR_HUMAN	TF -> target gene	TRANSFAC
57	CREB1_HUMAN	MITF_HUMAN	TF -> target gene	TRANSFAC
58	MK07_HUMAN	CDK9_HUMAN	kinase -> substrate	Robert H Newman (2013)
59	CSK22_HUMAN	HNRPK_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	SOX10_HUMAN	MITF_HUMAN	TF -> target gene	TRANSFAC
61	MLTK_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
62	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
63	WEE1_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	PTN1_HUMAN	MK01_HUMAN	phosphatase -> substrate	HPRD
65	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
66	MK08_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
67	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
68	PTN1_HUMAN	STA5B_HUMAN	phosphatase -> substrate	HPRD
69	MK08_HUMAN	MK01_HUMAN	kinase -> substrate	Robert H Newman (2013)
70	SGK1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos
71	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
72	E2AK2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
73	WEE1_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
74	DUS1_HUMAN	MK01_HUMAN	phosphatase -> substrate	HPRD
75	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
76	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
77	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
78	RIPK3_HUMAN	MK01_HUMAN	kinase -> substrate	Robert H Newman (2013)
79	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
80	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
81	AAPK2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	KKCC1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
83	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
84	AAPK1_HUMAN	CDK2_HUMAN	kinase -> substrate	Robert H Newman (2013)
85	CHK1_HUMAN	CDK1_HUMAN	kinase -> substrate	KEGG
86	EGR1_HUMAN	TGFR2_HUMAN	TF -> target gene	TRANSFAC
87	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
88	WEE1_HUMAN	CDK2_HUMAN	kinase -> substrate	HPRD
89	KKCC1_HUMAN	AKT1_HUMAN	kinase -> substrate	HPRD
90	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
91	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
92	PTN1_HUMAN	STA5A_HUMAN	phosphatase -> substrate	HPRD
93	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
94	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
95	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
96	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
97	SGK1_HUMAN	GSK3B_HUMAN	kinase -> substrate	RegPhos
98	WEE1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
99	AAPK2_HUMAN	HNF4A_HUMAN	kinase -> substrate	HPRD; RegPhos
100	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
101	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
102	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
103	EGR1_HUMAN	ELK1_HUMAN	TF -> target gene	TRANSFAC
104	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
105	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
106	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
107	KPCA_HUMAN	KGP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
108	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
109	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
110	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
111	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	CDK9_HUMAN	ANDR_HUMAN	kinase -> substrate	NetPath
113	EGFR_HUMAN	STA5A_HUMAN	kinase -> substrate	KEGG
114	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
115	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
116	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
117	KKCC1_HUMAN	KCC4_HUMAN	kinase -> substrate	HPRD
118	EGFR_HUMAN	STA5B_HUMAN	kinase -> substrate	RegPhos
119	MK08_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
120	AAPK2_HUMAN	EP300_HUMAN	kinase -> substrate	RegPhos
121	PTPRC_HUMAN	LCK_HUMAN	phosphatase -> substrate	HPRD; KEGG
122	KPCA_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD
123	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
124	AAPK1_HUMAN	MTOR_HUMAN	kinase -> substrate	KEGG; HPRD
125	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
126	KPCA_HUMAN	CTNB1_HUMAN	kinase -> substrate	KEGG
127	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
128	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
129	GSK3B_HUMAN	CEBPA_HUMAN	kinase -> substrate	RegPhos
130	MK01_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
131	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
132	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
133	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
134	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
135	MK01_HUMAN	STF1_HUMAN	kinase -> substrate	HPRD
136	MK01_HUMAN	BCL6_HUMAN	kinase -> substrate	NetPath
137	MK01_HUMAN	CEBPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
138	JAK1_HUMAN	STAT6_HUMAN	kinase -> substrate	RegPhos; NetPath
139	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
140	KS6A2_HUMAN	GABPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
141	MK01_HUMAN	STK16_HUMAN	kinase -> substrate	Robert H Newman (2013)
142	MK01_HUMAN	SRBP2_HUMAN	kinase -> substrate	Robert H Newman (2013)
143	CDK2_HUMAN	NFYA_HUMAN	kinase -> substrate	HPRD
144	TGFR2_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
145	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
146	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
147	KS6A2_HUMAN	CEBPB_HUMAN	kinase -> substrate	RegPhos
148	KS6A2_HUMAN	CSEN_HUMAN	kinase -> substrate	Robert H Newman (2013)
149	MK01_HUMAN	SOS1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
150	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
151	MK01_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD
152	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
153	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
154	MK01_HUMAN	MYB_HUMAN	kinase -> substrate	HPRD
155	KS6A2_HUMAN	KS6A1_HUMAN	kinase -> substrate	RegPhos
156	MK01_HUMAN	SRBP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
157	CDK2_HUMAN	TFDP1_HUMAN	kinase -> substrate	RegPhos
158	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
159	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
160	KGP1_HUMAN	STF1_HUMAN	kinase -> substrate	HPRD
161	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
162	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
163	CDK2_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
164	MK01_HUMAN	CEBPB_HUMAN	kinase -> substrate	HPRD
165	STAT1_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
166	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
167	FOXO4_HUMAN	BCL6_HUMAN	TF -> target gene	TRANSFAC
168	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
169	MK01_HUMAN	THB_HUMAN	kinase -> substrate	Robert H Newman (2013)
170	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
171	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
172	STA5A_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
173	KCC4_HUMAN	CEBPB_HUMAN	kinase -> substrate	Robert H Newman (2013)
174	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
175	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
176	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
177	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
178	TGFR2_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
179	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
180	SP1_HUMAN	PHX2A_HUMAN	TF -> target gene	TRANSFAC
181	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
182	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
183	STK16_HUMAN	IRF5_HUMAN	kinase -> substrate	Robert H Newman (2013)
184	SP1_HUMAN	AP2C_HUMAN	TF -> target gene	TRANSFAC
185	SP1_HUMAN	RARA_HUMAN	TF -> target gene	TRANSFAC
186	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
187	SP1_HUMAN	SP3_HUMAN	TF -> target gene	TRANSFAC
188	CDK7_HUMAN	RARA_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
189	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
190	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
191	FGFR1_HUMAN	EXOS5_HUMAN	kinase -> substrate	Robert H Newman (2013)
192	FGFR1_HUMAN	FGFR1_HUMAN	kinase -> substrate	RegPhos
193	FGFR1_HUMAN	NDF1_HUMAN	kinase -> substrate	Robert H Newman (2013)
194	FGFR1_HUMAN	RS10_HUMAN	kinase -> substrate	Robert H Newman (2013)
195	ZAGL2_HUMAN	FGFR1_HUMAN	kinase -> substrate	RegPhos
196	FGFR1_HUMAN	ANXA2_HUMAN	kinase -> substrate	Robert H Newman (2013)
197	FGFR1_HUMAN	CSRP3_HUMAN	kinase -> substrate	Robert H Newman (2013)
198	FGFR1_HUMAN	IF4H_HUMAN	kinase -> substrate	Robert H Newman (2013)
199	FGFR1_HUMAN	LSR_HUMAN	kinase -> substrate	Robert H Newman (2013)
200	FGFR1_HUMAN	HCLS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
201	FGFR1_HUMAN	SRC8_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
202	SHB_HUMAN	FGFR1_HUMAN	kinase -> substrate	HPRD
203	FGFR1_HUMAN	BPL1_HUMAN	kinase -> substrate	Robert H Newman (2013)
204	FGFR1_HUMAN	PLCG1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
205	FGFR1_HUMAN	XPR1_HUMAN	kinase -> substrate	Robert H Newman (2013)
206	FGFR1_HUMAN	ANS1A_HUMAN	kinase -> substrate	Robert H Newman (2013)
207	FGFR1_HUMAN	KAP0_HUMAN	kinase -> substrate	Robert H Newman (2013)
208	FGFR1_HUMAN	BCAR1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
209	FGFR1_HUMAN	MTA1_HUMAN	kinase -> substrate	Robert H Newman (2013)
210	FGFR1_HUMAN	HNRPQ_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
211	FGFR1_HUMAN	CSDE1_HUMAN	kinase -> substrate	Robert H Newman (2013)
212	FGFR1_HUMAN	DDX6_HUMAN	kinase -> substrate	Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network