Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ESR1_HUMAN
Description:estrogen receptor 1 [Source:HGNC Symbol;Acc:3467]
Location:chr6 q25.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S236KNRRKsCQACRPKA_groupphosphoELM; RegPhos
S236KNRRKsCQACRphosphoELM
S154FYRPNsDNRRQphosphoELM
S236KNRRKsCQACRzf-C4PhosphoSitePlus
S104PLNSVsPSPLMGSK-3_betaphosphoELM
S118PPPQLsPFLQPMAPK3phosphoELM
S118PPPQLsPFLQPMAPK1HPRD; phosphoELM
S118PPPQLsPFLQPMAPK_groupphosphoELM; RegPhos
T311LALSLtADQMVp38a(MAPK14RegPhos
S118PPPQLsPFLQPMAPKAPK2RegPhos
S559SRGGAsVEETDESR1_CPhosphoSitePlus
Y219QGHNDyMCPATphosphoELM
T311LALSLtADQMVPhosphoSitePlus; phosphoELM
Y537NVVPLyDLLLESrcRegPhos
S167RERLAsTNDKGAKT_groupRegPhos
S46EVYLDsSKPAVOest_recepPhosphoSitePlus
S167RERLAsTNDKGCK2_groupRegPhos
S167RERLAsTNDKGphosphoELM
S118PPPQLsPFLQPRPS6KA1HPRD
Y537NVVPLyDLLLESRCHPRD; phosphoELM; RegPhos
Y537NVVPLyDLLLELckphosphoELM; RegPhos
S106NSVSPsPLMLLOest_recepPhosphoSitePlus
S167RERLAsTNDKGOest_recepPhosphoSitePlus
Y537NVVPLyDLLLELCKHPRD; RegPhos
S118PPPQLsPFLQPCDK7HPRD; phosphoELM; RegPhos
Y537NVVPLyDLLLEHormone_recepPhosphoSitePlus
S102FPPLNsVSPSPGSK-3_betaphosphoELM
S167RERLAsTNDKGRPS6KA3HPRD
S167RERLAsTNDKGRPS6KA1HPRD
S104PLNSVsPSPLMMNAT1HPRD
S118PPPQLsPFLQPGSK-3_betaphosphoELM
S102FPPLNsVSPSPP51948(MAT1RegPhos
S104PLNSVsPSPLMphosphoELM
S305RSKKNsLALSLPhosphoSitePlus; phosphoELM
S118PPPQLsPFLQPErk1(MAPK3RegPhos
S167RERLAsTNDKGPKB_betaphosphoELM
S106NSVSPsPLMLLCDK2RegPhos
S118PPPQLsPFLQPRSK_groupphosphoELM
S118PPPQLsPFLQPGSK3B(GSK3 betaRegPhos
S118PPPQLsPFLQPOest_recepPhosphoSitePlus
T4__MTMtLHTKAPhosphoSitePlus
S102FPPLNsVSPSPGSK3B(GSK3 betaRegPhos
S282RGEVGsAGDMRPhosphoSitePlus; phosphoELM
T311LALSLtADQMVMAPK14HPRD; phosphoELM
S104PLNSVsPSPLMOest_recepPhosphoSitePlus
S118PPPQLsPFLQPErk2RegPhos
S106NSVSPsPLMLLphosphoELM
S118PPPQLsPFLQPRSK3RegPhos
S106NSVSPsPLMLLP51948(MAT1RegPhos
T2____MtMTLHTPhosphoSitePlus
T311LALSLtADQMVMAPK_groupphosphoELM; RegPhos
S104PLNSVsPSPLMCDK2RegPhos
S212AFFKRsIQGHNphosphoELM
S47VYLDSsKPAVYphosphoELM
S167RERLAsTNDKGRSK2RegPhos
Y52SKPAVyNYPEGphosphoELM
S102FPPLNsVSPSPphosphoELM
S167RERLAsTNDKGAKT1HPRD; RegPhos
S167RERLAsTNDKGAKT2HPRD; RegPhos
S106NSVSPsPLMLLGSK3B(GSK3 betaRegPhos
S212AFFKRsIQGHNzf-C4PhosphoSitePlus
Y52SKPAVyNYPEGOest_recepPhosphoSitePlus
S106NSVSPsPLMLLCDK_groupphosphoELM; RegPhos
S104PLNSVsPSPLMP51948(MAT1RegPhos
S554LHAPTsRGGASphosphoELM
S102FPPLNsVSPSPMNAT1HPRD
S104PLNSVsPSPLMCDK_groupphosphoELM; RegPhos
S118PPPQLsPFLQPphosphoELM; RegPhos
Y219QGHNDyMCPATzf-C4PhosphoSitePlus
S102FPPLNsVSPSPOest_recepPhosphoSitePlus
S47VYLDSsKPAVYOest_recepPhosphoSitePlus
T485DKITDtLIHLMHormone_recepPhosphoSitePlus
Y537NVVPLyDLLLEphosphoELM
S10LHTKAsGMALLPhosphoSitePlus; RegPhos
Y537NVVPLyDLLLETyr-kinasesRegPhos
S167RERLAsTNDKGAkt2(PKB betaRegPhos
S106NSVSPsPLMLLMNAT1HPRD
S167RERLAsTNDKGRSK_groupphosphoELM; RegPhos
S106NSVSPsPLMLLGSK-3_betaphosphoELM
T311LALSLtADQMVp38aRegPhos
S559SRGGAsVEETDphosphoELM
S167RERLAsTNDKGRSK3RegPhos
S46EVYLDsSKPAVphosphoELM
T7TMTLHtKASGMPhosphoSitePlus; RegPhos
S554LHAPTsRGGASESR1_CPhosphoSitePlus
S294ANLWPsPLMIKPhosphoSitePlus; phosphoELM
S305RSKKNsLALSLPAK1HPRD; phosphoELM; RegPhos
S104PLNSVsPSPLMGSK3B(GSK3 betaRegPhos
S154FYRPNsDNRRQOest_recepPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y537CKNVVPLyDLLLEMLPTPN6HPRD
Y537CKNVVPLyDLLLEMLPTPN1HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000342630D538GCOSMICBreast Cancer20668451
ENSP00000206249M264IHPIBreast Cancer17224074
ENSP00000387500M490ICOSMICLung Cancer20668451
ENSP00000387500D538GCOSMICBreast Cancer20668451
ENSP00000405330H6YHPIBreast Cancer17224074
ENSP00000206249D538GCOSMICBreast Cancer20668451
ENSP00000405330M490ICOSMICLung Cancer20668451
ENSP00000342630M264IHPIBreast Cancer17224074
ENSP00000405330M264IHPIBreast Cancer17224074
ENSP00000342630M490ICOSMICLung Cancer20668451
ENSP00000405330S341LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000342630H6YHPIBreast Cancer17224074
ENSP00000206249M490ICOSMICLung Cancer20668451
ENSP00000387500M264IHPIBreast Cancer17224074
ENSP00000206249H6YHPIBreast Cancer17224074
ENSP00000387500H6YHPIBreast Cancer17224074
ENSP00000405330L489VCOSMICOvarian Cancer20668451
ENSP00000342630L489VCOSMICOvarian Cancer20668451
ENSP00000387500L489VCOSMICOvarian Cancer20668451
ENSP00000405330D538GCOSMICBreast Cancer20668451
ENSP00000206249S341LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000206249L489VCOSMICOvarian Cancer20668451
ENSP00000342630S341LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000387500S341LCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
ESR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S118Oest_recepLHPPPQLsPFLQPHGbreast cancer12118371PhosphoSitePlus
S167Oest_recepGGRERLAsTNDKGSMbreast cancer19940156PhosphoSitePlus
S106Oest_recepPLNSVSPsPLMLLHPbreast cancer20418363PhosphoSitePlus
T311NSLALSLtADQMVSAbreast cancer20418363PhosphoSitePlus
S167Oest_recepGGRERLAsTNDKGSMbreast cancer20418363PhosphoSitePlus
S294RAANLWPsPLMIKRSbreast cancer20418363PhosphoSitePlus
S118Oest_recepLHPPPQLsPFLQPHGbreast cancer16168121PhosphoSitePlus
S167Oest_recepGGRERLAsTNDKGSMbreast cancer16168121PhosphoSitePlus
S118Oest_recepLHPPPQLsPFLQPHGbreast cancer19940281PhosphoSitePlus
S282EGRGEVGsAGDMRAAbreast cancer20418363PhosphoSitePlus
S559ESR1_CPTSRGGAsVEETDQSbreast cancer20418363PhosphoSitePlus
S104Oest_recepFPPLNSVsPSPLMLLbreast cancer20418363PhosphoSitePlus
S118Oest_recepLHPPPQLsPFLQPHGbreast cancer20418363PhosphoSitePlus
Y52Oest_recepDSSKPAVyNYPEGAAbreast cancer20101225PhosphoSitePlus
Y219zf-C4SIQGHNDyMCPATNQbreast cancer20101225PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANESR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
AKT2_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos
KS6A2_HUMANESR1_HUMANkinase -> substrateRegPhos
MAT1_HUMANESR1_HUMANkinase -> substrateHPRD
LCK_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KS6A1_HUMANESR1_HUMANkinase -> substrateHPRD
PKN1_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
FAK2_HUMANESR1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
SRC_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos
MK14_HUMANESR1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANESR1_HUMANkinase -> substrateRegPhos
MAPK2_HUMANESR1_HUMANkinase -> substrateRegPhos
MK01_HUMANESR1_HUMANkinase -> substrateHPRD
KS6A3_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos
MK03_HUMANESR1_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANESR1_HUMANkinase -> substrateRegPhos
PTN6_HUMANESR1_HUMANphosphatase -> substrateHPRD
PTN1_HUMANESR1_HUMANphosphatase -> substrateHPRD
ESR1_HUMANCATD_HUMANTF -> target geneTRANSFAC
ESR1_HUMANAPOE_HUMANTF -> target geneTRANSFAC
ESR1_HUMANNQO1_HUMANTF -> target geneTRANSFAC
ESR1_HUMANFOS_HUMANTF -> target geneTRANSFAC
ESR1_HUMANPRGR_HUMANTF -> target geneTRANSFAC
ESR1_HUMANNHRF1_HUMANTF -> target geneTRANSFAC
ESR1_HUMANTRFE_HUMANTF -> target geneTRANSFAC
ESR1_HUMANPTMA_HUMANTF -> target geneTRANSFAC
ESR1_HUMANTGFA_HUMANTF -> target geneTRANSFAC
ESR1_HUMANCO3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04961Endocrine and other factor-regulated calcium reabs

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030520intracellular estrogen receptor signaling pathwayNASbiological_process
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0060065uterus developmentIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003707steroid hormone receptor activityTASmolecular_function
GO:0060750epithelial cell proliferation involved in mammary IEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0071391cellular response to estrogen stimulusIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0043627response to estrogen stimulusIDAbiological_process
GO:0051000positive regulation of nitric-oxide synthase activIDAbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0005496steroid bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0060745mammary gland branching involved in pregnancyIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0060068vagina developmentIEAbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:0010629negative regulation of gene expressionIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0060523prostate epithelial cord elongationIEAbiological_process
GO:0060687regulation of branching involved in prostate glandIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0030235nitric-oxide synthase regulator activityNASmolecular_function
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorNASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0038052estrogen-activated sequence-specific DNA binding RIGImolecular_function
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0030284estrogen receptor activityIEAmolecular_function
GO:0008209androgen metabolic processIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0016020membraneNAScellular_component
GO:0034056estrogen response element bindingIDAmolecular_function
GO:0002064epithelial cell developmentIEAbiological_process
GO:0001547antral ovarian follicle growthIEAbiological_process
GO:0048386positive regulation of retinoic acid receptor signIDAbiological_process
GO:0060527prostate epithelial cord arborization involved in IEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0016585chromatin remodeling complexNAScellular_component
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0008134transcription factor bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0001046core promoter sequence-specific DNA bindingIDAmolecular_function