Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SP3_HUMAN
Description:Sp3 transcription factor [Source:HGNC Symbol;Acc:11208]
Location:chr2 q31.1
Node attribute:gene; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S563EEWQLsGDSTLPhosphoSitePlus; HPRD; phosphoELM
S646HLRWHsGERPFzf-H2C2_2PhosphoSitePlus; SysPTM
S566QLSGDsTLNTNHPRD; phosphoELM
T65ALLAAtCSKIGPhosphoSitePlus
S73KIGPPsPGDDEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T676HRRTHtGEKKFzf-H2C2_2PhosphoSitePlus
T674QRHRRtHTGEKzf-H2C2_2PhosphoSitePlus
S646HLRWHsGERPFHPRD; phosphoELM; SysPTM
S67LAATCsKIGPPPhosphoSitePlus
T601RRVACtCPNCKPhosphoSitePlus
S665KRFTRsDELQRPhosphoSitePlus

Dephosphorylation site
SP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000388903S60TBIOMARTBreast Cancer21930507, 21930502
ENSP00000310301P208LCOSMICHead and Neck Cancer
ENSP00000310301S113TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
SP3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP3_HUMANFOSL1_HUMANTF -> target geneTRANSFAC
SP3_HUMANSP1_HUMANTF -> target geneTRANSFAC
SP3_HUMANAP2C_HUMANTF -> target geneTRANSFAC
SP3_HUMANCCND1_HUMANTF -> target geneTRANSFAC
SP3_HUMANNOS1_HUMANTF -> target geneTRANSFAC
SP3_HUMANLCAT_HUMANTF -> target geneTRANSFAC
SP3_HUMANE2F1_HUMANTF -> target geneTRANSFAC
SP3_HUMANP53_HUMANTF -> target geneTRANSFAC
SP3_HUMANHMOX1_HUMANTF -> target geneTRANSFAC
SP3_HUMANTGFR2_HUMANTF -> target geneTRANSFAC
SP3_HUMANAOFB_HUMANTF -> target geneTRANSFAC
SP3_HUMANDHB1_HUMANTF -> target geneTRANSFAC
SP3_HUMANLORI_HUMANTF -> target geneTRANSFAC
SP3_HUMANPHX2A_HUMANTF -> target geneTRANSFAC
SP3_HUMANHAND1_HUMANTF -> target geneTRANSFAC
SP3_HUMANGROA_HUMANTF -> target geneTRANSFAC
SP1_HUMANSP3_HUMANTF -> target geneTRANSFAC
SP3_HUMANRET_HUMANTF -> target geneTRANSFAC
SP3_HUMANK1C16_HUMANTF -> target geneTRANSFAC
SP3_HUMANTTF1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
SP3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001889liver developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0000987core promoter proximal region sequence-specific DNIEAmolecular_function
GO:0048596embryonic camera-type eye morphogenesisIEAbiological_process
GO:0001078RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0048706embryonic skeletal system developmentIEAbiological_process
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030224monocyte differentiationIEAbiological_process
GO:0060216definitive hemopoiesisIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060136embryonic process involved in female pregnancyIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0030219megakaryocyte differentiationIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0001503ossificationIEAbiological_process
GO:0017053transcriptional repressor complexIEAcellular_component
GO:0043353enucleate erythrocyte differentiationIEAbiological_process
GO:0030851granulocyte differentiationIEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0005634nucleusICcellular_component
GO:0001829trophectodermal cell differentiationIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component


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