| UniProt/SwissProt ID: | SP3_HUMAN |
| Description: | Sp3 transcription factor [Source:HGNC Symbol;Acc:11208] |
| Location: | chr2 q31.1 |
| Node attribute: | gene; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S563 | EEWQLsGDSTL | PhosphoSitePlus; HPRD; phosphoELM | |
| S646 | HLRWHsGERPF | zf-H2C2_2 | PhosphoSitePlus; SysPTM |
| S566 | QLSGDsTLNTN | HPRD; phosphoELM | |
| T65 | ALLAAtCSKIG | PhosphoSitePlus | |
| S73 | KIGPPsPGDDE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T676 | HRRTHtGEKKF | zf-H2C2_2 | PhosphoSitePlus |
| T674 | QRHRRtHTGEK | zf-H2C2_2 | PhosphoSitePlus |
| S646 | HLRWHsGERPF | HPRD; phosphoELM; SysPTM | |
| S67 | LAATCsKIGPP | PhosphoSitePlus | |
| T601 | RRVACtCPNCK | PhosphoSitePlus | |
| S665 | KRFTRsDELQR | PhosphoSitePlus | |
| Dephosphorylation site |
| SP3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000388903 | S60T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000310301 | P208L | COSMIC | Head and Neck Cancer | ENSP00000310301 | S113T | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SP3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SP3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP3_HUMAN | FOSL1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | SP1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | AP2C_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | CCND1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | NOS1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | LCAT_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | E2F1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | P53_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | HMOX1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | TGFR2_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | AOFB_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | DHB1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | LORI_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | PHX2A_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | HAND1_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | GROA_HUMAN | TF -> target gene | TRANSFAC |
| SP1_HUMAN | SP3_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | RET_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | K1C16_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | TTF1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SP3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001889 | liver development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0001892 | embryonic placenta development | IEA | biological_process |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0000987 | core promoter proximal region sequence-specific DN | IEA | molecular_function |
| GO:0048596 | embryonic camera-type eye morphogenesis | IEA | biological_process |
| GO:0001078 | RNA polymerase II core promoter proximal region se | IEA | molecular_function |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0048706 | embryonic skeletal system development | IEA | biological_process |
| GO:0001779 | natural killer cell differentiation | IEA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IDA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0030218 | erythrocyte differentiation | IEA | biological_process |
| GO:0000979 | RNA polymerase II core promoter sequence-specific | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030224 | monocyte differentiation | IEA | biological_process |
| GO:0060216 | definitive hemopoiesis | IEA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0060136 | embryonic process involved in female pregnancy | IEA | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0030219 | megakaryocyte differentiation | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0001503 | ossification | IEA | biological_process |
| GO:0017053 | transcriptional repressor complex | IEA | cellular_component |
| GO:0043353 | enucleate erythrocyte differentiation | IEA | biological_process |
| GO:0030851 | granulocyte differentiation | IEA | biological_process |
| GO:0030217 | T cell differentiation | IEA | biological_process |
| GO:0003690 | double-stranded DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IC | cellular_component |
| GO:0001829 | trophectodermal cell differentiation | IEA | biological_process |
| GO:0030324 | lung development | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |