Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ATF4_HUMAN
Description:activating transcription factor 4 (tax-responsive enhancer element B67) [Source:HGNC Symbol;Acc:786]
Location:chr22 q13.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S224SGICMsPESYLPhosphoSitePlus
S245GSPNRsLPSPGRSK2RegPhos
S245GSPNRsLPSPGRSK-2phosphoELM
S69VDGLVsPSNNSHPRD
S219PSDNDsGICMSPhosphoSitePlus; phosphoELM; RegPhos
S245GSPNRsLPSPGPhosphoSitePlus

Dephosphorylation site
ATF4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384587D152HBIOMARTBreast Cancer21930507, 21930502
ENSP00000379912D152HBIOMARTBreast Cancer21930507, 21930502
ENSP00000336790D152HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ATF4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S245TRGSPNRsLPSPGVLbreast cancer22052162PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A3_HUMANATF4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCA_HUMANATF4_HUMANkinase -> substrateKEGG
KS6A6_HUMANATF4_HUMANkinase -> substrateKEGG
MKNK2_HUMANATF4_HUMANkinase -> substrateKEGG
ZAGL2_HUMANATF4_HUMANkinase -> substrateRegPhos
MAPK3_HUMANATF4_HUMANkinase -> substrateKEGG
KS6A4_HUMANATF4_HUMANkinase -> substrateKEGG
ATF4_HUMANTVA2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa05215Prostate cancer
hsa05166HTLV-I infection
hsa04912GnRH signaling pathway
hsa05034Alcoholism
hsa05203Viral carcinogenesis
hsa04725Cholinergic synapse
hsa04141Protein processing in endoplasmic reticulum
hsa04722Neurotrophin signaling pathway
hsa04728Dopaminergic synapse
hsa05030Cocaine addiction
hsa05031Amphetamine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006366transcription from RNA polymerase II promoterISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0070059intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0007214gamma-aminobutyric acid signaling pathwayIEAbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0032590dendrite membraneIEAcellular_component
GO:0006094gluconeogenesisIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0043267negative regulation of potassium ion transportIEAbiological_process
GO:0006520cellular amino acid metabolic processTASbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005815microtubule organizing centerIEAcellular_component
GO:0070059intrinsic apoptotic signaling pathway in response ISSbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0034976response to endoplasmic reticulum stressIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0043525positive regulation of neuron apoptotic processISSbiological_process
GO:0034976response to endoplasmic reticulum stressIDAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0006355regulation of transcription, DNA-dependentISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0006094gluconeogenesisISSbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0005634nucleusISScellular_component


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