Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FUBP1_HUMAN
Description:far upstream element (FUSE) binding protein 1 [Source:HGNC Symbol;Acc:4004]
Location:chr1 p31.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S99QQQSRsVMTEEHPRD
S52GDAGTsLNSNDPhosphoSitePlus; HPRD
S84APQNDsFGTQLPhosphoSitePlus; HPRD
Y619AWAEYyRQQAADUF1897PhosphoSitePlus
S55GTSLNsNDYGYHPRD
Y60SNDYGyGGQKRPhosphoSitePlus
Y268EVRNEyGSRIGPhosphoSitePlus
Y4__MADySTVPPPhosphoSitePlus
S630YYAQTsPQGMPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T229DGPQNtGADKPKH_1PhosphoSitePlus
S140QIAPDsGGLPEHPRD; phosphoELM
S270RNEYGsRIGGNPhosphoSitePlus
Y618AAWAEyYRQQADUF1897PhosphoSitePlus
T229DGPQNtGADKPHPRD
T207GKGGEtIKQLQKH_1PhosphoSitePlus
Y58LNSNDyGYGGQPhosphoSitePlus; HPRD; phosphoELM
Y589KAWEEyYKKMGPhosphoSitePlus
S140QIAPDsGGLPEKH_1PhosphoSitePlus
T153CMLTGtPESVQKH_1PhosphoSitePlus; SysPTM
T153CMLTGtPESVQHPRD; phosphoELM; SysPTM
T207GKGGEtIKQLQHPRD
S156TGTPEsVQSAKKH_1PhosphoSitePlus
Y626QQAAYyAQTSPPhosphoSitePlus; HPRD
Y242ITGDPyKVQQAKH_1PhosphoSitePlus
T398GKGGEtIKSISKH_1PhosphoSitePlus
Y4TVPPHPRD
T629AYYAQtSPQGMPhosphoSitePlus; HPRD; SysPTM
Y625RQQAAyYAQTSPhosphoSitePlus; HPRD

Dephosphorylation site
FUBP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359804P281LCOSMICCentral Nervous System Neoplasms18772396
ENSP00000359804H463fs*>182COSMICCentral Nervous System Neoplasms21817013
ENSP00000359804Q548*COSMICHead and Neck Cancer21798893
ENSP00000359804E445*COSMICCentral Nervous System Neoplasms21817013
ENSP00000359804E411*COSMICCentral Nervous System Neoplasms21817013
ENSP00000359804D570fs*>75COSMICCentral Nervous System Neoplasms21817013
ENSP00000359804A596TCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000359804Gastric CancerMetastasiscell lineDown0.6917022644
ENSP00000359804Hepatocellular CarcinomaNormal vs. CancertissueUp2.915759316
ENSP00000359804LeukemiaNormal vs. Cancercell lineDown0.4717022645
ENSP00000359804LeukemiaNormal vs. Cancercell lineDown0.4717022645
ENSP00000359804Lung CancerTreatment (none vs. FK228 treatment)cell lineDown18549279
ENSP00000359804Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.418491314
ENSP00000359804hepatitis B virusNormal vs. CancertissueUp3.619003864
ENSP00000359804Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp5.519137550
ENSP00000359804Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp6.319137550
ENSP00000359804Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.220804217
ENSP00000359804Gastric CancerMetastasiscell lineDown0.6917022644
ENSP00000359804chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineDown20417730
ENSP00000359804acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0617655343
ENSP00000359804acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0917655343
ENSP00000359804acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1217655343
ENSP00000359804acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0717655343
ENSP00000359804acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0917655343
ENSP00000359804acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1817655343
ENSP00000359804acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown17655343
ENSP00000359804Ovarian CancerMetastasiscell lineUp17892554
ENSP00000359804Biliary Tract CancerMetastasiscell lineUp3.119299076
ENSP00000359804Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineDown0.420944110

Hyperphosphorylation site
FUBP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANFUBP1_HUMANkinase -> substrateRobert H Newman (2013)
FUBP1_HUMANMYC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
FUBP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003697single-stranded DNA bindingTASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0005515protein bindingIEAmolecular_function


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