Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFAC2_HUMAN
Description:nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [Source:HGNC Symbol;Acc:7776]
Location:chr20 q13.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T599QQMILtGQNFTHPRD; phosphoELM
S280PSPQPsSHVAPHPRD
S337VSAAPsKAGLPPhosphoSitePlus
S882NGPPVsDQKEVPhosphoSitePlus; HPRD
S171CLSPAsSGSSAHPRD
S177SGSSAsFISDTHPRD
T599QQMILtGQNFTTIGPhosphoSitePlus
Y860LSPGSyPTVIQPhosphoSitePlus
T893LPAGVtIKQEQPhosphoSitePlus
T485TGKTVtTTSYERHDPhosphoSitePlus
Y752PAAVLyQRSKSPhosphoSitePlus
S243VPRPAsRSSSPPhosphoSitePlus; HPRD
S757YQRSKsLSPSLPhosphoSitePlus; HPRD
Y38LFDYEyLNPNEPhosphoSitePlus
T585VERQDtDSCLVHPRD; phosphoELM
S221TSPIMsPRTSLPhosphoSitePlus; HPRD
S268LPPGAsPQRSRHPRD
Y36SILFDyEYLNPPhosphoSitePlus
T652NKHIRtPVKVNTIGPhosphoSitePlus
S77YSPLAsLSGEPHPRD
S110GASGLsPRIEIPhosphoSitePlus
Y904NLDQTyLDDVNPhosphoSitePlus
S225MSPRTsLAEDSPhosphoSitePlus
S180SASFIsDTFSPHPRD
S99PQKFLsAAKPAPhosphoSitePlus; HPRD
T374LLVPPtWPKPLPhosphoSitePlus; HPRD
S755VLYQRsKSLSPPhosphoSitePlus
S245RPASRsSSPGAPhosphoSitePlus
S213IPAHYsPRTSPPhosphoSitePlus; HPRD
T585VERQDtDSCLVTIGPhosphoSitePlus
S236CLGRHsPVPRPPhosphoSitePlus; HPRD
S363GERRNsAPESIPhosphoSitePlus; HPRD
S761KSLSPsLLGYQPhosphoSitePlus
S856QGQRLsPGSYPPhosphoSitePlus
Y212NIPAHySPRTSPhosphoSitePlus
Y346LPRHIyPAVEFPhosphoSitePlus
S776MAAPLsLADAHPhosphoSitePlus
S326KMWKTsPDPSPPhosphoSitePlus; HPRD; phosphoELM
S217YSPRTsPIMSPPhosphoSitePlus; HPRD
T483RITGKtVTTTSRHDPhosphoSitePlus
S736FRTGLsSPDARPhosphoSitePlus
S148AGVAAsPRFTLPhosphoSitePlus
S73GLKPYsPLASLPhosphoSitePlus
S276RSRSPsPQPSSHPRD
S605GQNFTsESKVVTIGPhosphoSitePlus
S107KPAGAsGLSPRPhosphoSitePlus
T483RITGKtVTTTSHPRD
T325PKMWKtSPDPSHPRD
S333DPSPVsAAPSKPhosphoSitePlus
S172LSPASsGSSASHPRD
S274PQRSRsPSPQPHPRD
S174PASSGsSASFIHPRD
S168EPLCLsPASSGHPRD
S247ASRSSsPGAKRPhosphoSitePlus
S53AHKVAsPPSGPPhosphoSitePlus
S859RLSPGsYPTVIPhosphoSitePlus
S255AKRRHsCAEALPhosphoSitePlus
S759RSKSLsPSLLGPhosphoSitePlus; HPRD
S175ASSGSsASFISHPRD
S605GQNFTsESKVVHPRD; phosphoELM
S330TSPDPsPVSAAPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S280RSPSPQPsSHVAPQDPPP3CBHPRD
S213QNIPAHYsPRTSPIMPPP3CBHPRD
S221PRTSPIMsPRTSLAEPPP3CBHPRD
S276PQRSRSPsPQPSSHVPPP3CBHPRD
S363EQGERRNsAPESILLPPP3CBHPRD
S326PPKMWKTsPDPSPVSPPP3CBHPRD
S268VALPPGAsPQRSRSPPPP3CBHPRD
S274ASPQRSRsPSPQPSSHPRD
S236DSCLGRHsPVPRPASPPP3CBHPRD
T116LSPRIEItPSHELIQPPP3CBHPRD
S217AHYSPRTsPIMSPRTPPP3CBHPRD
S274ASPQRSRsPSPQPSSPPP3CBHPRD
S99VGPQKFLsAAKPAGAPPP3CBHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379330G197ECOSMICSkin Cancer21984974
ENSP00000379330I518TCOSMICOvarian Cancer21720365

Differential expressed protein
NFAC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NFAC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANNFAC2_HUMANkinase -> substrateKEGG
PP2BA_HUMANNFAC2_HUMANphosphatase -> substrateNetPath
CHP1_HUMANNFAC2_HUMANphosphatase -> substrateKEGG
PP2BB_HUMANNFAC2_HUMANphosphatase -> substrateHPRD; NetPath
NFAC2_HUMANICAM1_HUMANTF -> target geneTRANSFAC
NFAC2_HUMANEGR3_HUMANTF -> target geneTRANSFAC
NFAC2_HUMANIL4_HUMANTF -> target geneTRANSFAC
NFAC2_HUMANCSF2_HUMANTF -> target geneTRANSFAC
NFAC2_HUMANIL3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation
hsa05166HTLV-I infection
hsa04010MAPK signaling pathway
hsa04310Wnt signaling pathway
hsa04660T cell receptor signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0030890positive regulation of B cell proliferationIMPbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0016477cell migrationIDAbiological_process
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0001816cytokine productionIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0050853B cell receptor signaling pathwayIMPbiological_process
GO:0042493response to drugIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process


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