Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	P73_HUMAN
Description:	tumor protein p73 [Source:HGNC Symbol;Acc:12003]
Location:	chr1 p36.32
Node attribute:	gene; substrate; TF

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y99	PTHSPyAQPSS		PhosphoSitePlus
S47	VGGTDsSMDVF		PhosphoSitePlus
Y28	EPDSTyFDLPQ		PhosphoSitePlus
T86	SASPYtPEHAA	CDC2	RegPhos
S388	QPLVDsYRQQQ		PhosphoSitePlus
S471	MSSSHsAQSMV		PhosphoSitePlus
S235	VTGRQsVVVPY	P53	PhosphoSitePlus
T167	QIKVStPPPPG	P53	PhosphoSitePlus
Y99	PTHSPyAQPSS	Abl	phosphoELM
T86	SASPYtPEHAA	CDK1	HPRD
T86	SASPYtPEHAA	CDK2	HPRD; phosphoELM; RegPhos
T86	SASPYtPEHAA		PhosphoSitePlus
T568	SSNAAtISIGG		PhosphoSitePlus
Y99	PTHSPyAQPSS	ABL1	HPRD; RegPhos
T173	PPPPGtAIRAM	P53	PhosphoSitePlus
S47	VGGTDsSMDVF	CHK1	phosphoELM; RegPhos
T27	LEPDStYFDLP		PhosphoSitePlus

Dephosphorylation site

P73_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000367545	Q133H	COSMIC	Ovarian Cancer	21720365
ENSP00000367545	E373D	Ding2008, COSMIC	Lung Cancer	18948947

Differential expressed protein

P73_HUMAN is not differential expressed protein.

Hyperphosphorylation site

P73_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
CHK1_HUMAN	P73_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK2_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
P53_HUMAN	P73_HUMAN	TF -> target gene	KEGG
P73_HUMAN	BAX_HUMAN	TF -> target gene	TRANSFAC
ZEB1_HUMAN	P73_HUMAN	TF -> target gene	TRANSFAC
P73_HUMAN	P73_HUMAN	TF -> target gene	TRANSFAC
P53_HUMAN	P73_HUMAN	TF -> target gene	TRANSFAC
P73_HUMAN	ADA_HUMAN	TF -> target gene	TRANSFAC
P73_HUMAN	CDN1A_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa04115	p53 signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05162	Measles

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0010332	response to gamma radiation	IBA	biological_process
GO:0048546	digestive tract morphogenesis	IEA	biological_process
GO:0043524	negative regulation of neuron apoptotic process	IBA	biological_process
GO:0003690	double-stranded DNA binding	IBA	molecular_function
GO:0001836	release of cytochrome c from mitochondria	IEA	biological_process
GO:0008134	transcription factor binding	IPI	molecular_function
GO:0021766	hippocampus development	IEA	biological_process
GO:0043065	positive regulation of apoptotic process	IEA	biological_process
GO:0005667	transcription factor complex	IBA	cellular_component
GO:0034644	cellular response to UV	IBA	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0006298	mismatch repair	TAS	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0043565	sequence-specific DNA binding	IEA	molecular_function
GO:0003684	damaged DNA binding	IBA	molecular_function
GO:0030900	forebrain development	IEA	biological_process
GO:0006978	DNA damage response, signal transduction by p53 cl	IBA	biological_process
GO:0002039	p53 binding	IEA	molecular_function
GO:0006974	response to DNA damage stimulus	IDA	biological_process
GO:0043524	negative regulation of neuron apoptotic process	IEA	biological_process
GO:0043066	negative regulation of apoptotic process	IEA	biological_process
GO:0010243	response to organic nitrogen	IEA	biological_process
GO:0009791	post-embryonic development	IEA	biological_process
GO:0006974	response to DNA damage stimulus	IEA	biological_process
GO:0002039	p53 binding	IBA	molecular_function
GO:0048714	positive regulation of oligodendrocyte differentia	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0006351	transcription, DNA-dependent	IEA	biological_process
GO:0000187	activation of MAPK activity	IEA	biological_process
GO:0043508	negative regulation of JUN kinase activity	IBA	biological_process
GO:0019901	protein kinase binding	IPI	molecular_function
GO:0001822	kidney development	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor	IDA	molecular_function
GO:0031571	mitotic cell cycle G1/S transition DNA damage chec	IBA	biological_process
GO:0000785	chromatin	IBA	cellular_component
GO:0007050	cell cycle arrest	IEA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0045893	positive regulation of transcription, DNA-dependen	IDA	biological_process
GO:0033326	cerebrospinal fluid secretion	IEA	biological_process
GO:0045665	negative regulation of neuron differentiation	IEA	biological_process
GO:0003682	chromatin binding	IBA	molecular_function
GO:0000785	chromatin	IEA	cellular_component
GO:0043508	negative regulation of JUN kinase activity	IEA	biological_process
GO:0000122	negative regulation of transcription from RNA poly	IBA	biological_process
GO:0010165	response to X-ray	IBA	biological_process
GO:0042771	intrinsic apoptotic signaling pathway in response	IBA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IDA	biological_process
GO:0045793	positive regulation of cell size	IEA	biological_process
GO:0005829	cytosol	IBA	cellular_component
GO:0042802	identical protein binding	IPI	molecular_function
GO:0008630	intrinsic apoptotic signaling pathway in response	TAS	biological_process
GO:0003677	DNA binding	IEA	molecular_function
GO:0005515	protein binding	IEA	molecular_function
GO:0043523	regulation of neuron apoptotic process	IEA	biological_process
GO:0051262	protein tetramerization	IEA	biological_process
GO:0006355	regulation of transcription, DNA-dependent	IEA	biological_process
GO:0048666	neuron development	IEA	biological_process
GO:0005634	nucleus	IEA	cellular_component

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network