Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EP300_HUMAN
Description:E1A binding protein p300 [Source:HGNC Symbol;Acc:3373]
Location:chr22 q13.2
Node attribute:acetylation(source); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S89LLRSGsSPNLNPKC_alphaphosphoELM
S89LLRSGsSPNLNPKC_deltaphosphoELM
S1834RRRMAsMQRTGPKB_groupphosphoELM
S89LLRSGsSPNLNCaM-KI_groupphosphoELM
S1037TSATQsSPAPGPhosphoSitePlus; HPRD; phosphoELM
S24SSPALsASASDCaMK4RegPhos
S833HQNSPsPVPSRPhosphoSitePlus
T938PPQPAtPLSQPPhosphoSitePlus
S2328PHSSPsPRMQPPhosphoSitePlus
S1044PAPGQsKKKIFPhosphoSitePlus
Y1414LRTAVyHEILIKAT11PhosphoSitePlus
S2309SNQVRsPQPVPPhosphoSitePlus
S1834RRRMAsMQRTGPhosphoSitePlus
S1834RRRMAsMQRTGAKT1HPRD; RegPhos
Y1446SEGDDyIFHCHKAT11PhosphoSitePlus
Y620VEGDMyESANNKIXPhosphoSitePlus
S2366QGHFAsPDQNSPhosphoSitePlus
Y1424IGYLEyVKKLGKAT11PhosphoSitePlus
T841PSRTPtPHHTPPhosphoSitePlus
S2279QPNPMsPQQHMPhosphoSitePlus
S1038SATQSsPAPGQPhosphoSitePlus; HPRD
T845PTPHHtPPSIGPhosphoSitePlus
Y638LAEKIyKIQKEKIXPhosphoSitePlus
S1834RRRMAsMQRTGAKT_groupRegPhos
T839PVPSRtPTPHHPhosphoSitePlus
T885PPPRQtPTPPTPhosphoSitePlus; HPRD; phosphoELM
S89LLRSGsSPNLNCaMK1_groupRegPhos
S12EPGPPsAKRPKPhosphoSitePlus
T1296KRLPStRLGTFPhosphoSitePlus
S89LLRSGsSPNLNPKCa(PKC alphaRegPhos
S831ALHQNsPSPVPPhosphoSitePlus
S89LLRSGsSPNLNAMPK_groupphosphoELM; RegPhos
S1295AKRLPsTRLGTPhosphoSitePlus
S1534REENTsNESTDKAT11PhosphoSitePlus
T1960QMPPMtPMAPMPhosphoSitePlus
T1533KREENtSNESTKAT11PhosphoSitePlus
S89LLRSGsSPNLNPKCdRegPhos
S285LSNNLsPFAMDPhosphoSitePlus; HPRD
S2315PQPVPsPRPQSPhosphoSitePlus
S24SSPALsASASDCaM-KIVphosphoELM
T1857PATPTtPTGQQHPRD
Y630NRAEYyHLLAEKIXPhosphoSitePlus
Y611ENLVAyARKVEKIXPhosphoSitePlus
Y1421EILIGyLEYVKKAT11PhosphoSitePlus
S89LLRSGsSPNLNPKCd(PKC deltaRegPhos
Y1355AESFPyRTKALKAT11PhosphoSitePlus
T887PRQTPtPPTTQPhosphoSitePlus; HPRD
Y2219PQGVGyPPQQQPhosphoSitePlus
Y629NNRAEyYHLLAKIXPhosphoSitePlus
T1135LYNRKtSRVYKBromodomainPhosphoSitePlus
T317QPGLVtPVAQGPhosphoSitePlus
S89LLRSGsSPNLNPhosphoSitePlus; phosphoELM
S106GQVMAsQAQQSPhosphoSitePlus
S89LLRSGsSPNLNPRKCDHPRD
T1859TPTTPtGQQPTHPRD

Dephosphorylation site
EP300_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263253Y1397HCOSMICLymphoma21390126
ENSP00000263253P1452HCOSMICSkin Cancer21984974
ENSP00000263253Y1131NBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000263253R580*COSMICIntestines Cancer10700188
ENSP00000263253E1013GHPI, COSMICBreast Cancer10700188
ENSP00000263253P1880SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000263253E1014*COSMICIntestines Cancer12402157
ENSP00000263253R1680CCOSMICIntestines Cancer8622873
ENSP00000263253P2221QCOSMICIntestines Cancer10700188
ENSP00000263253R86*COSMICIntestines Cancer12385008
ENSP00000263253F2211LBIOMARTBrain Cancer21930507, 21930502
ENSP00000263253D1399YCOSMICGastric Cancer8622873
ENSP00000263253S1650YHPI, COSMICPancreatic Cancer10700188
ENSP00000263253Q974*COSMICSkin Cancer22006338
ENSP00000263253D618EBIOMARTBreast Cancer21930507, 21930502
ENSP00000263253S697NBIOMARTBreast Cancer21930507, 21930502
ENSP00000263253S507GCOSMICLymphoma21390126
ENSP00000263253P2221QOMIM, HPIColorectal Cancer10700188
ENSP00000263253K1570NCOSMICLymphoma21390126
ENSP00000263253A2143TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000263253R1599HCOSMICLymphoma21390126
ENSP00000263253R1312*COSMICOvarian Cancer21720365
ENSP00000263253G1506VCOSMICLymphoma21390126
ENSP00000263253R1950SCOSMICLung Cancer
ENSP00000263253M2175LCOSMICLymphoma21390126
ENSP00000263253L2303FCOSMICSkin Cancer21984974
ENSP00000263253R1627WCOSMICLymphoma21390126
ENSP00000263253C1790GBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000263253L827PHPI, COSMICBreast Cancer10700188
ENSP00000263253A590PCOSMICLymphoma21390126
ENSP00000263253P1337SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000263253P925TCOSMICLymphoma21390126
ENSP00000263253E646QCOSMICBreast Cancer20668451
ENSP00000263253Q1904PCOSMICLymphoma21390126
ENSP00000263253Q821*COSMICLymphoma21390126
ENSP00000263253M126VCOSMICLymphoma21390126
ENSP00000263253Q63*COSMICLymphoma21390126
ENSP00000263253C1385FCOSMICHead and Neck Cancer21798893

Differential expressed protein
EP300_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EP300_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAPK2_HUMANEP300_HUMANkinase -> substrateRegPhos
KPCA_HUMANEP300_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANEP300_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
AKT1_HUMANEP300_HUMANkinase -> substrateHPRD; RegPhos
EP300_HUMANSTAT3_HUMANacetylationNetPath
EP300_HUMANANDR_HUMANacetylationNetPath
EP300_HUMANCCND1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04720Long-term potentiation
hsa05211Renal cell carcinoma
hsa04630Jak-STAT signaling pathway
hsa04330Notch signaling pathway
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa04916Melanogenesis
hsa05203Viral carcinogenesis
hsa04520Adherens junction
hsa04110Cell cycle
hsa05215Prostate cancer
hsa05016Huntington's disease
hsa04350TGF-beta signaling pathway
hsa04310Wnt signaling pathway
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa05152Tuberculosis
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042771intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0043923positive regulation by host of viral transcriptionIDAbiological_process
GO:0001666response to hypoxiaIDAbiological_process
GO:0004468lysine N-acetyltransferase activityIDAmolecular_function
GO:0071456cellular response to hypoxiaTASbiological_process
GO:0043967histone H4 acetylationIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0001102RNA polymerase II activating transcription factor IEAmolecular_function
GO:0016407acetyltransferase activityIMPmolecular_function
GO:0009887organ morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0001102RNA polymerase II activating transcription factor IPImolecular_function
GO:0007219Notch signaling pathwayTASbiological_process
GO:0003712transcription cofactor activityIEAmolecular_function
GO:0060765regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0043627response to estrogen stimulusIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001047core promoter bindingIDAmolecular_function
GO:0003682chromatin bindingIMPmolecular_function
GO:0050681androgen receptor bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0018076N-terminal peptidyl-lysine acetylationIDAbiological_process
GO:0004402histone acetyltransferase activityIDAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0033554cellular response to stressTASbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0061418regulation of transcription from RNA polymerase IITASbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0018393internal peptidyl-lysine acetylationIDAbiological_process
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0002039p53 bindingIEAmolecular_function
GO:0016746transferase activity, transferring acyl groupsIDAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0000123histone acetyltransferase complexIEAcellular_component
GO:0030324lung developmentIEAbiological_process
GO:0006915apoptotic processIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0016573histone acetylationIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIEAmolecular_function