Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LCK_HUMAN
Description:lymphocyte-specific protein tyrosine kinase [Source:HGNC Symbol;Acc:6524]
Location:chr1 p35.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y394IEDNEyTAREGLCKHPRD; RegPhos
Y263EVWMGyYNGHTPkinase_TyrPhosphoSitePlus
Y505ATEGQyQPQPRegPhos
S162ESTAGsFSLSVphosphoELM; RegPhos
S42LIRNGsEVRDPPKCaRegPhos
Y394IEDNEyTAREGPkinase_TyrPhosphoSitePlus
S102WWKAQsLTTGQSH3_1PhosphoSitePlus
Y505ATEGQyQPQPCSKRegPhos
Y264VWMGYyNGHTKPkinase_TyrPhosphoSitePlus
S59SNPPAsPLQDNPhosphoSitePlus; phosphoELM; RegPhos
S194GGFYIsPRITFphosphoELM; RegPhos
Y25CENCHyPIVPLPhosphoSitePlus
S59SNPPAsPLQDNErk2RegPhos
S42LIRNGsEVRDPErk1(MAPK3RegPhos
T50RDPLVtYEGSNPhosphoSitePlus
S42LIRNGsEVRDPPRKCAHPRD
S59SNPPAsPLQDNErk1RegPhos
S42LIRNGsEVRDPErk2(MAPK1RegPhos
S158IRESEsTAGSFSH2PhosphoSitePlus
S274KVAVKsLKQGSPkinase_TyrPhosphoSitePlus
Y394IEDNEyTAREGLckphosphoELM; RegPhos
Y51DPLVTyEGSNPPhosphoSitePlus
S492FDYLRsVLEDFPkinase_TyrPhosphoSitePlus
Y209ELVRHyTNASDSH2PhosphoSitePlus
Y192DNGGFyISPRISH2PhosphoSitePlus
S42LIRNGsEVRDPPKACaRegPhos
T35LDGKGtLLIRNPhosphoSitePlus
Y505ATEGQyQPHPRD; phosphoELM
Y505ATEGQyQPCSKHPRD
S59SNPPAsPLQDNMAPK3HPRD
S133FFKNLsRKDAEHPRD
S194GGFYIsPRITFSH2PhosphoSitePlus
Y192DNGGFyISPRIHPRD; phosphoELM; RegPhos
Y414PEAINyGTFTIPkinase_TyrPhosphoSitePlus
Y505ATEGQyQPLckphosphoELM
T210LVRHYtNASDGPhosphoSitePlus
S158IRESEsTAGSFphosphoELM; RegPhos
Y470CPEELyQLMRLPkinase_TyrPhosphoSitePlus
Y394IEDNEyTAREGFCGR3AHPRD
T395EDNEYtAREGAPkinase_TyrPhosphoSitePlus
S156FLIREsESTAGSH2PhosphoSitePlus
S162ESTAGsFSLSVSH2PhosphoSitePlus
Y505ATEGQyQPQP_PhosphoSitePlus
Y394IEDNEyTAREGP08637(CD16RegPhos
Y489RPTFDyLRSVLPkinase_TyrPhosphoSitePlus
Y394IEDNEyTAREGHPRD; phosphoELM
T159RESEStAGSFSSH2PhosphoSitePlus
T501DFFTAtEGQYQPhosphoSitePlus; phosphoELM; RegPhos
S213HYTNAsDGLCTPhosphoSitePlus; phosphoELM; RegPhos
Y393LIEDNeYTAREHPRD
Y394IEDNEyTAREGautocatalysisRegPhos
T416AINYGtFTIKSPkinase_TyrPhosphoSitePlus
Y505ATEGQyQPQPLckRegPhos
T268YYNGHtKVAVKPkinase_TyrPhosphoSitePlus
T375ILVSDtLSCKIPkinase_TyrPhosphoSitePlus
S42LIRNGsEVRDPMAPK1phosphoELM
S281KQGSMsPDAFLPkinase_TyrPhosphoSitePlus
S42LIRNGsEVRDPPhosphoSitePlus
S59SNPPAsPLQDNMAPK1HPRD
S42LIRNGsEVRDPMAPK3phosphoELM
Y192DNGGFyISPRISYKHPRD; RegPhos
S42LIRNGsEVRDPPRKACAHPRD
Y181EVVKHyKIRNLSH2PhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y505FTATEGQyQPQPPTPRCHPRD
Y394RLIEDNEyTAREGAKPTPN6HPRD
Y394RLIEDNEyTAREGAKPTPN22HPRD
Y394RLIEDNEyTAREGAKPTPRCHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337825P447LHPILeukemia8139546
ENSP00000337825P331SDing2008Lung Cancer18948947
ENSP00000337825A353VHPILeukemia8139546
ENSP00000337825V28LHPILeukemia8139546

Differential expressed protein
LCK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LCK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LCK_HUMANSPTN1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANKPCD_HUMANkinase -> substrateRegPhos
LCK_HUMANMUC1_HUMANkinase -> substrateNetPath
LCK_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANITK_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
LCK_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANZAP70_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
LCK_HUMANNAR4_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANLIME1_HUMANkinase -> substrateRegPhos; NetPath
LCK_HUMANSIG10_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANPLCG2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANKPCT_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LCK_HUMANCD5_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANCD28_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANIRAK1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANSHC1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LCK_HUMANTRI16_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANLCP2_HUMANkinase -> substrateRegPhos; NetPath
LCK_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANPTN6_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANVAV2_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANPPAC_HUMANkinase -> substrateRegPhos
LCK_HUMANP85A_HUMANkinase -> substrateHPRD; RegPhos; NetPath
LCK_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LCK_HUMANSIT1_HUMANkinase -> substrateNetPath
LCK_HUMANVAV_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
LCK_HUMANSOCS3_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANLAX1_HUMANkinase -> substrateNetPath
LCK_HUMANLCK_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANKSYK_HUMANkinase -> substrateNetPath
FCG3A_HUMANLCK_HUMANkinase -> substrateHPRD
LCK_HUMANEZRI_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LCK_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANPTEN_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANMAD1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANLCK_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
LCK_HUMANMED28_HUMANkinase -> substrateHPRD
CSK_HUMANLCK_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANCD79B_HUMANkinase -> substrateRegPhos; NetPath
LCK_HUMANCD3Z_HUMANkinase -> substrateNetPath
KSYK_HUMANLCK_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANSLAF1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANDAPP1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LCK_HUMANT22D3_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos; NetPath
ZAGL2_HUMANLCK_HUMANkinase -> substrateRegPhos
LCK_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANDEFI6_HUMANkinase -> substrateHPRD
LCK_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANGAB2_HUMANkinase -> substrateNetPath
LCK_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LCK_HUMANCD3E_HUMANkinase -> substrateRegPhos
LCK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANMK01_HUMANkinase -> substrateNetPath
LCK_HUMANTRAT1_HUMANkinase -> substrateNetPath
LCK_HUMANSH2B3_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
KPCA_HUMANLCK_HUMANkinase -> substrateHPRD
LCK_HUMANCD33_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANHDAC8_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANLCK_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
LCK_HUMANIL2RB_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
LCK_HUMANRASA1_HUMANkinase -> substrateHPRD; RegPhos
LCK_HUMANVDR_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANCD79A_HUMANkinase -> substrateNetPath
PTPRH_HUMANLCK_HUMANphosphatase -> substrateNetPath
PTN22_HUMANLCK_HUMANphosphatase -> substrateHPRD
PTN6_HUMANLCK_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANLCK_HUMANphosphatase -> substrateHPRD; KEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05340Primary immunodeficiency
hsa05166HTLV-I infection
hsa04650Natural killer cell mediated cytotoxicity
hsa04064NF-kappa B signaling pathway
hsa04660T cell receptor signaling pathway
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042610CD8 receptor bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0051209release of sequestered calcium ion into cytosolIEAbiological_process
GO:0030097hemopoiesisNASbiological_process
GO:0042493response to drugISSbiological_process
GO:0006882cellular zinc ion homeostasisISSbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIPImolecular_function
GO:0042609CD4 receptor bindingIPImolecular_function
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0006919activation of cysteine-type endopeptidase activityISSbiological_process
GO:0005829cytosolTAScellular_component
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0070474positive regulation of uterine smooth muscle contrIEAbiological_process
GO:0006917induction of apoptosisISSbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0051249regulation of lymphocyte activationNASbiological_process
GO:0050862positive regulation of T cell receptor signaling pNASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0003823antigen bindingIEAmolecular_function
GO:0000242pericentriolar materialISScellular_component
GO:0016032viral reproductionTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0010038response to metal ionIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0030217T cell differentiationISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0050856regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0050870positive regulation of T cell activationISSbiological_process
GO:0042169SH2 domain bindingISSmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0030139endocytic vesicleIEAcellular_component
GO:0042523positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0004722protein serine/threonine phosphatase activityISSmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0001948glycoprotein bindingIPImolecular_function
GO:0031295T cell costimulationTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0001772immunological synapseIDAcellular_component
GO:0050690regulation of defense response to virus by virusTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0045588positive regulation of gamma-delta T cell differenIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0051117ATPase bindingIPImolecular_function
GO:0010043response to zinc ionIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function


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