| UniProt/SwissProt ID: | PO2F1_HUMAN |
| Description: | POU class 2 homeobox 1 [Source:HGNC Symbol;Acc:9212] |
| Location: | chr1 q24.1 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S167 | TQIPLsQPIQI | PhosphoSitePlus | |
| S448 | GGTSSsPIKAI | PhosphoSitePlus; phosphoELM; RegPhos | |
| S143 | QQHSAsQQHSA | PhosphoSitePlus | |
| S267 | QTLPQsQSTPK | PhosphoSitePlus | |
| T445 | PSSGGtSSSPI | PhosphoSitePlus | |
| S283 | SLEEPsDLEEL | phosphoELM | |
| S141 | AVQQHsASQQH | PhosphoSitePlus | |
| T276 | PKRIDtPSLEE | PhosphoSitePlus; phosphoELM | |
| S81 | EESGDsQQPSQ | PhosphoSitePlus | |
| S385 | RKKRTsIETNI | PKA_group | phosphoELM; RegPhos |
| S92 | PSQQPsVQAAI | PhosphoSitePlus | |
| S447 | SGGTSsSPIKA | PhosphoSitePlus; phosphoELM | |
| S78 | KSNEEsGDSQQ | PhosphoSitePlus | |
| T259 | RTIAAtPIQTL | PhosphoSitePlus | |
| S85 | DSQQPsQPSQQ | PhosphoSitePlus | |
| S446 | SSGGTsSSPIK | PhosphoSitePlus | |
| T270 | PQSQStPKRID | PhosphoSitePlus; phosphoELM | |
| S278 | RIDTPsLEEPS | PhosphoSitePlus; phosphoELM | |
| T100 | AAIPQtQLMLA | PhosphoSitePlus | |
| S283 | SLEEPsDLEEL | Pou | PhosphoSitePlus |
| S385 | RKKRTsIETNI | CDK7 | phosphoELM; RegPhos |
| S269 | LPQSQsTPKRI | PhosphoSitePlus; phosphoELM | |
| S232 | QLPQQsQANLL | PhosphoSitePlus | |
| S385 | RKKRTsIETNI | phosphoELM | |
| S385 | RKKRTsIETNI | Homeobox | PhosphoSitePlus |
| T162 | AATPMtQIPLS | PhosphoSitePlus | |
| S88 | QPSQPsQQPSV | PhosphoSitePlus | |
| S335 | EALNLsFKNMC | Pou | PhosphoSitePlus |
| T226 | AQNLLtQLPQQ | PhosphoSitePlus | |
| S147 | ASQQHsAAGAT | PhosphoSitePlus | |
| Dephosphorylation site |
| PO2F1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000453094 | R285Q | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000356836 | R285Q | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000271411 | S88F | Sjoblom2006, HPI, BIOMART | Breast Cancer | 16959974, 21930507, 21930502 |
| Differential expressed protein |
| PO2F1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PO2F1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | PO2F1_HUMAN | kinase -> substrate | RegPhos |
| CDK7_HUMAN | PO2F1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| PO2F1_HUMAN | H2B1J_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | INVO_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | IGLL5_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | LIPL_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | LYN_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | IL3_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | HBG1_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | CCND1_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | IL2_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | IL5_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | HBB_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | U2AFM_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | IGHA1_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | ARY1_HUMAN | TF -> target gene | TRANSFAC |
| PO2F1_HUMAN | MYC_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PO2F1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IDA | molecular_function |
| GO:0006383 | transcription from RNA polymerase III promoter | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0060235 | lens induction in camera-type eye | IEA | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0030910 | olfactory placode formation | IEA | biological_process |
| GO:0001077 | RNA polymerase II core promoter proximal region se | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |