Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOXO1_HUMAN
Description:forkhead box O1 [Source:HGNC Symbol;Acc:3819]
Location:chr13 q14.11
Node attribute:PPI(source); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S256RRRAAsMDNNSPKB_groupphosphoELM
S325NASTIsGRLSPPhosphoSitePlus
S319RPRTSsNASTISGK_groupphosphoELM; RegPhos
S322TSSNAsTISGRCK1a(CK1 alphaRegPhos
S325NASTIsGRLSPPKB_groupphosphoELM
S322TSSNAsTISGRPKB_groupphosphoELM
T24RPRSCtWPLPRAKT_groupRegPhos
S325NASTIsGRLSPCK1a(CK1 alphaRegPhos
S319RPRTSsNASTIAKT_groupRegPhos
S218IRHNLsLHSKFFork_headPhosphoSitePlus
S432GQSSMsPLPQMPhosphoSitePlus; HPRD; phosphoELM
S651KTTTHsWVSG_PhosphoSitePlus
S322TSSNAsTISGRCSNK1G1HPRD
S325NASTIsGRLSPGSK3BHPRD; RegPhos
S256RRRAAsMDNNSFork_headPhosphoSitePlus
S383LNLLSsPTSLTPhosphoSitePlus
S319RPRTSsNASTIAKT1(PKB) RegPhos
S394VSTQSsPGTMMPhosphoSitePlus
S322TSSNAsTISGRAKT_groupRegPhos
S287EGAGDsPGSQFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S303SPGSHsNDDFDPhosphoSitePlus
S319RPRTSsNASTIPhosphoSitePlus
S212AGWKNsIRHNLFork_headPhosphoSitePlus
T24RPRSCtWPLPRAKT1HPRD; RegPhos
S416NTSLNsPSPNYPhosphoSitePlus
T24RPRSCtWPLPRSGK_groupphosphoELM; RegPhos
T402TMMQQtPCYSFPhosphoSitePlus
S509MSTYGsQASHNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S256RRRAAsMDNNSAKT1HPRD; RegPhos
S298SKWPAsPGSHSPhosphoSitePlus
T478HNDIMtPVDPGHPRD; phosphoELM
S325NASTIsGRLSPCK1_alphaphosphoELM
S468KELLTsDSPPHRegPhos
S418SLNSPsPNYQKPhosphoSitePlus
S319RPRTSsNASTIPKB_groupphosphoELM
S256RRRAAsMDNNSSGK_groupphosphoELM; RegPhos
S322TSSNAsTISGRDYRK1ARegPhos
T467LKELLtSDSPPRegPhos
S325NASTIsGRLSPGSK_groupRegPhos
S325NASTIsGRLSPAKT_groupRegPhos
S256RRRAAsMDNNSPAK1HPRD; RegPhos
S249GKSGKsPRRRAFork_headPhosphoSitePlus
S301PASPGsHSNDDPhosphoSitePlus
S322TSSNAsTISGRPhosphoSitePlus
S234EGTGKsSWWMLFork_headPhosphoSitePlus
T24RPRSCtWPLPRPKB_groupphosphoELM
S322TSSNAsTISGRCK1g1RegPhos
S293PGSQFsKWPASPhosphoSitePlus
S235GTGKSsWWMLNFork_headPhosphoSitePlus
S322TSSNAsTISGRCK1_alphaphosphoELM
S329ISGRLsPIMTEDYRK1AHPRD; phosphoELM; RegPhos
T24RPRSCtWPLPRAKT1(PKB) RegPhos
S256RRRAAsMDNNSAKT1(PKB) RegPhos
S319RPRTSsNASTIAKT1HPRD; RegPhos
S505PNSVMsTYGSQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T24RPRSCtWPLPRPhosphoSitePlus
S256RRRAAsMDNNSAKT_groupRegPhos
S329ISGRLsPIMTEPhosphoSitePlus
S470LLTSDsPPHNDPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
FOXO1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368880T358ICOSMICHead and Neck Cancer21798893

Differential expressed protein
FOXO1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S256Fork_headSPRRRAAsMDNNSKFhepatitis18316359PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
SGK1_HUMANFOXO1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANFOXO1_HUMANkinase -> substrateRegPhos
AKT1_HUMANFOXO1_HUMANkinase -> substrateRegPhos; NetPath
KC1A_HUMANFOXO1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANFOXO1_HUMANkinase -> substrateHPRD; RegPhos
KC1G1_HUMANFOXO1_HUMANkinase -> substrateHPRD
DYR1A_HUMANFOXO1_HUMANkinase -> substrateRegPhos
PKN1_HUMANFOXO1_HUMANkinase -> substrateHPRD; RegPhos
AKT3_HUMANFOXO1_HUMANkinase -> substrateKEGG
FOXO1_HUMANPRGC1_HUMANotherKEGG
FOXO1_HUMANPCKGC_HUMANTF -> target geneKEGG
FOXO1_HUMANF16P1_HUMANTF -> target geneKEGG
FOXO1_HUMANG6PC_HUMANTF -> target geneKEGG
FOXO1_HUMANIBP1_HUMANTF -> target geneTRANSFAC
FOXO1_HUMANPDK4_HUMANTF -> target geneTRANSFAC
FOXO1_HUMANG6PC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05215Prostate cancer
hsa04910Insulin signaling pathway
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0003690double-stranded DNA bindingIBAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005667transcription factor complexIBAcellular_component
GO:0001568blood vessel developmentIBAbiological_process
GO:0001078RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0001659temperature homeostasisISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0045599negative regulation of fat cell differentiationISSbiological_process
GO:0003682chromatin bindingISSmolecular_function
GO:0045722positive regulation of gluconeogenesisIEAbiological_process
GO:0070417cellular response to coldISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006473protein acetylationISSbiological_process
GO:0031018endocrine pancreas developmentTASbiological_process
GO:0019901protein kinase bindingIBAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0034599cellular response to oxidative stressISSbiological_process
GO:0005829cytosolIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0009790embryo developmentIBAbiological_process
GO:0045444fat cell differentiationISSbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0009888tissue developmentIBAbiological_process
GO:0051721protein phosphatase 2A bindingISSmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0001678cellular glucose homeostasisISSbiological_process
GO:0008134transcription factor bindingIBAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006974response to DNA damage stimulusISSbiological_process
GO:0071732cellular response to nitric oxideIEAbiological_process
GO:0042127regulation of cell proliferationIBAbiological_process
GO:0048513organ developmentIBAbiological_process
GO:0044429mitochondrial partISScellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0034599cellular response to oxidative stressIEAbiological_process
GO:0007389pattern specification processIBAbiological_process
GO:0032873negative regulation of stress-activated MAPK cascaIDAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0071732cellular response to nitric oxideISSbiological_process
GO:2000505regulation of energy homeostasisISSbiological_process
GO:0008286insulin receptor signaling pathwayISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051721protein phosphatase 2A bindingIEAmolecular_function
GO:0051090regulation of sequence-specific DNA binding transcIBAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0009267cellular response to starvationISSbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIBAmolecular_function
GO:0005829cytosolISScellular_component