Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AHR_HUMAN
Description:aryl hydrocarbon receptor [Source:HGNC Symbol;Acc:348]
Location:chr7 p21.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S12NITYAsRKRRKPKC_alphaphosphoELM
S68KLDKLsVLRLSHLHPhosphoSitePlus
S36IKSNPsKRHRDPKC_alphaphosphoELM
S12NITYAsRKRRKPhosphoSitePlus
S232LLDNSsGFLAMPhosphoSitePlus
S75LRLSVsYLRAKHLHPhosphoSitePlus
S12NITYAsRKRRKPKCa(PKC alphaRegPhos
Y76RLSVSyLRAKSHLHPhosphoSitePlus
S36IKSNPsKRHRDPKCa(PKC alphaRegPhos
S36IKSNPsKRHRDHLHPhosphoSitePlus
Y322TRGSGyQFIHAPAS_3PhosphoSitePlus
S68KLDKLsVLRLSphosphoELM; RegPhos
Y378NGRPDyIIVTQHPRD; phosphoELM; RegPhos

Dephosphorylation site
AHR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000242057N484KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000242057Q683ECOSMICOvarian Cancer21720365
ENSP00000242057T821SCOSMICRenal Cancer20054297
ENSP00000242057S473*BIOMARTBreast Cancer21930507, 21930502
ENSP00000436466Q683ECOSMICOvarian Cancer21720365
ENSP00000242057M556ICOSMICPancreatic Cancer
ENSP00000436466M556ICOSMICPancreatic Cancer
ENSP00000436466D48NCOSMICOther Cancer
ENSP00000436466T821SCOSMICRenal Cancer20054297
ENSP00000242057D48NCOSMICOther Cancer

Differential expressed protein
AHR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AHR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANAHR_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANAHR_HUMANkinase -> substrateRegPhos
AHR_HUMANFOS_HUMANTF -> target geneTRANSFAC
AHR_HUMANHSPB1_HUMANTF -> target geneTRANSFAC
AHR_HUMANCP1A1_HUMANTF -> target geneTRANSFAC
AHR_HUMANTFF1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
AHR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001568blood vessel developmentNASbiological_process
GO:0006805xenobiotic metabolic processTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0004879ligand-activated sequence-specific DNA binding RNAIDAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0048608reproductive structure developmentIEAbiological_process
GO:0030850prostate gland developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045899positive regulation of RNA polymerase II transcripIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0046982protein heterodimerization activityTASmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0051879Hsp90 protein bindingIDAmolecular_function
GO:0006950response to stressIDAbiological_process
GO:0007049cell cycleTASbiological_process
GO:0034752cytosolic aryl hydrocarbon receptor complexTAScellular_component
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0010468regulation of gene expressionIDAbiological_process
GO:0048732gland developmentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0030522intracellular receptor mediated signaling pathwayIDAbiological_process
GO:0046983protein dimerization activityTASmolecular_function
GO:0009410response to xenobiotic stimulusIDAbiological_process
GO:0030888regulation of B cell proliferationIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005667transcription factor complexTAScellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23