Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TF65_HUMAN
Description:v-rel reticuloendotheliosis viral oncogene homolog A (avian) [Source:HGNC Symbol;Acc:9955]
Location:chr11 q13.1
Node attribute:TF; substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S543ADMDFsALLSQCK2a1RegPhos
Y306KRKRTyETFKSPhosphoSitePlus
S131LEQAIsQRIQTRHDPhosphoSitePlus
S42KCEGRsAGSIPRHDPhosphoSitePlus
S536DEDFSsIADMDCHUKHPRD
S536DEDFSsIADMDp38a(MAPK14RegPhos
T435QAGEGtLSEALErk2(MAPK1RegPhos
S311YETFKsIMKKSPKCzRegPhos
S536DEDFSsIADMDIKK_alphaphosphoELM
S311YETFKsIMKKSPhosphoSitePlus
S536DEDFSsIADMDIKK_groupphosphoELM; RegPhos
S205NRNSGsCLGGDPhosphoSitePlus
S536DEDFSsIADMDIKKe(IKK epsilonRegPhos
S529PNGLLsGDEDFPhosphoSitePlus
T505ITRLVtGAQRPPhosphoSitePlus; phosphoELM; RegPhos
T71YTGPGtVRISLRHDPhosphoSitePlus
S276QLRRPsDRELSPhosphoSitePlus; phosphoELM
S45GRSAGsIPGERRHDPhosphoSitePlus
S536DEDFSsIADMDIKKaRegPhos
T435QAGEGtLSEALMAPK1phosphoELM
T254AIVFRtPPYADPhosphoSitePlus; phosphoELM; RegPhos
S468FTDLAsVDNSEPhosphoSitePlus; phosphoELM
S276QLRRPsDRELSPKACaRegPhos
T305EKRKRtYETFKPhosphoSitePlus
T435QAGEGtLSEALPhosphoSitePlus
S536DEDFSsIADMDIKKa(IKK alphaRegPhos
S543ADMDFsALLSQCSNK2A1HPRD
S536DEDFSsIADMDIKK_betaphosphoELM
S536DEDFSsIADMDIKK_epsilonphosphoELM
S547FSALLsQISS_PhosphoSitePlus
S276QLRRPsDRELSPRKACAHPRD
S543ADMDFsALLSQCK2a1-rsRegPhos
S281SDRELsEPMEFPhosphoSitePlus
S536DEDFSsIADMDPhosphoSitePlus; phosphoELM
S536DEDFSsIADMDTBK1phosphoELM; RegPhos
S311YETFKsIMKKSPRKCZHPRD
T308KRTYEtFKSIMPhosphoSitePlus
S276QLRRPsDRELSMSK1(RSK5RegPhos
S536DEDFSsIADMDIKKb(IKK betaRegPhos
S276QLRRPsDRELSMSK2RegPhos
S468FTDLAsVDNSEGSK-3_betaphosphoELM
S529PNGLLsGDEDFCK2_alphaphosphoELM
S529PNGLLsGDEDFCK2_groupphosphoELM; RegPhos
S529PNGLLsGDEDFCK2a1(CK2 alphaRegPhos
S276QLRRPsDRELSRSK-5phosphoELM
S468FTDLAsVDNSEGSK3B(GSK3 betaRegPhos
S276QLRRPsDRELSMSK1RegPhos
S311YETFKsIMKKSPKCz(PKC zetaRegPhos
S311YETFKsIMKKSPKC_zetaphosphoELM

Dephosphorylation site
TF65_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384273Q132*COSMICLung Cancer20668451
ENSP00000384273E127QCOSMICOvarian Cancer21720365
ENSP00000384273T55SCOSMICLung Cancer20668451
ENSP00000384273E498KCOSMICLung Cancer18948947

Differential expressed protein
TF65_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S536SGDEDFSsIADMDFShepatocellular carcinoma20224721PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANTF65_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
ZAGL2_HUMANTF65_HUMANkinase -> substrateRegPhos
FGFR4_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANTF65_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KS6A2_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANTF65_HUMANkinase -> substrateRegPhos; NetPath
KPCA_HUMANTF65_HUMANkinase -> substrateHPRD
MK01_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
IKKA_HUMANTF65_HUMANkinase -> substrateHPRD; NetPath
IKKB_HUMANTF65_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
KS6A4_HUMANTF65_HUMANkinase -> substrateRegPhos
YES_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANTF65_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCZ_HUMANTF65_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
MK14_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
2AAB_HUMANTF65_HUMANphosphatase -> substrateNetPath
PP2AA_HUMANTF65_HUMANphosphatase -> substrateNetPath
TF65_HUMANCCL2_HUMANTF -> target geneTRANSFAC
TF65_HUMANIFNB_HUMANTF -> target geneTRANSFAC
TF65_HUMANMEFV_HUMANTF -> target geneTRANSFAC
TF65_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
TF65_HUMANNFKB2_HUMANTF -> target geneTRANSFAC
TF65_HUMANCCND1_HUMANTF -> target geneTRANSFAC
TF65_HUMANFAK1_HUMANTF -> target geneTRANSFAC
TF65_HUMANCO1A2_HUMANTF -> target geneTRANSFAC
TF65_HUMANICAM1_HUMANTF -> target geneTRANSFAC
TF65_HUMANVCAM1_HUMANTF -> target geneTRANSFAC
TF65_HUMANCCL5_HUMANTF -> target geneTRANSFAC
TF65_HUMANIL6_HUMANTF -> target geneTRANSFAC
TF65_HUMANP53_HUMANTF -> target geneTRANSFAC
TF65_HUMANIFNG_HUMANTF -> target geneTRANSFAC
TF65_HUMANTNFA_HUMANTF -> target geneTRANSFAC
TF65_HUMANIL12B_HUMANTF -> target geneTRANSFAC
SP1_HUMANTF65_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04620Toll-like receptor signaling pathway
hsa04062Chemokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05221Acute myeloid leukemia
hsa05030Cocaine addiction
hsa04210Apoptosis
hsa05145Toxoplasmosis
hsa05212Pancreatic cancer
hsa05140Leishmaniasis
hsa05200Pathways in cancer
hsa05169Epstein-Barr virus infection
hsa04662B cell receptor signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05168Herpes simplex infection
hsa04010MAPK signaling pathway
hsa05146Amoebiasis
hsa05162Measles
hsa04064NF-kappa B signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04380Osteoclast differentiation
hsa05164Influenza A
hsa04623Cytosolic DNA-sensing pathway
hsa05160Hepatitis C
hsa05133Pertussis
hsa05215Prostate cancer
hsa05202Transcriptional misregulation in cancer
hsa04660T cell receptor signaling pathway
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05142Chagas disease (American trypanosomiasis)
hsa05134Legionellosis
hsa05203Viral carcinogenesis
hsa05166HTLV-I infection
hsa05131Shigellosis
hsa05152Tuberculosis
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa05132Salmonella infection
hsa04622RIG-I-like receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006952defense responseIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0032570response to progesterone stimulusIEAbiological_process
GO:0006954inflammatory responseIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0071532ankyrin repeat bindingIEAmolecular_function
GO:0032495response to muramyl dipeptideIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0071356cellular response to tumor necrosis factorIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0019899enzyme bindingIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0010224response to UV-BIDAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0010035response to inorganic substanceIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0070555response to interleukin-1IGIbiological_process
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0050727regulation of inflammatory responseIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0042177negative regulation of protein catabolic processIEAbiological_process
GO:0006117acetaldehyde metabolic processIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0051059NF-kappaB bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0014040positive regulation of Schwann cell differentiatioIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0042301phosphate ion bindingIDAmolecular_function
GO:0010033response to organic substanceIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0046627negative regulation of insulin receptor signaling IEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0010033response to organic substanceIDAbiological_process
GO:0006968cellular defense responseNASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0032332positive regulation of chondrocyte differentiationIEAbiological_process
GO:0043278response to morphineIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0071347cellular response to interleukin-1IDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0051607defense response to virusNASbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0070431nucleotide-binding oligomerization domain containiIDAbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0006950response to stressIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0070491repressing transcription factor bindingIPImolecular_function
GO:0051591response to cAMPIEAbiological_process
GO:0033590response to cobalaminIEAbiological_process
GO:0045084positive regulation of interleukin-12 biosyntheticIEAbiological_process