Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSDE1_HUMAN
Description:cold shock domain containing E1, RNA-binding [Source:HGNC Symbol;Acc:29905]
Location:chr1 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S445NPKTTsPNKGKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S123AAPGQsPTGSVPhosphoSitePlus; HPRD; phosphoELM
S514LLGRNsNSKRLPhosphoSitePlus; HPRD
S492DKVEFsISDKQHPRD
T761RLKNItLDDASPhosphoSitePlus
T413SNPKTtSPNKGHPRD
T677PLRRAtVECVKCSDPhosphoSitePlus
T168DNNKHtGAVSAHPRD
T137DNNKHtGAVSAHPRD
S116NLESKsPAAPGPhosphoSitePlus; HPRD; phosphoELM
T444SNPKTtSPNKGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y690FGFINyEVGDSCSDPhosphoSitePlus
S2____MsFDPNLPhosphoSitePlus
S461DKVEFsISDKQHPRD
T450DVEGStSPQIGHPRD
S483LLGRNsNSKRLHPRD
Y597ADPTIySGKVIPhosphoSitePlus
T481DVEGStSPQIGHPRD
Y141VFYLTyTPEDVPhosphoSitePlus
Y138NGEVFyLTYTPPhosphoSitePlus
S782RGPDNsMGFGAPhosphoSitePlus
S414NPKTTsPNKGKHPRD

Dephosphorylation site
CSDE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261443R725HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000351329P776SBIOMARTBreast Cancer21930507, 21930502
ENSP00000351329T35PCOSMICOvarian Cancer21720365
ENSP00000432958Q706*COSMICSkin Cancer21984974
ENSP00000261443E526QBIOMARTBreast Cancer21930507, 21930502
ENSP00000261443P745SBIOMARTBreast Cancer21930507, 21930502
ENSP00000342408E526QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432958L656FCOSMICOvarian Cancer21720365
ENSP00000351329Q706*COSMICSkin Cancer21984974
ENSP00000351329E557QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432958E557QBIOMARTBreast Cancer21930507, 21930502
ENSP00000432958P776SBIOMARTBreast Cancer21930507, 21930502
ENSP00000432958T35PCOSMICOvarian Cancer21720365
ENSP00000351329L656FCOSMICOvarian Cancer21720365
ENSP00000342408P745SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351329Gastric CancerMetastasiscell lineDown0.5617022644
ENSP00000351329Gastric CancerMetastasiscell lineDown0.5617022644

Hyperphosphorylation site
CSDE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCZ_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
STK24_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
NUAK1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
IRAK3_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CSDE1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008584male gonad developmentTASbiological_process