Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	CDK1_HUMAN
Description:	cyclin-dependent kinase 1 [Source:HGNC Symbol;Acc:1722]
Location:	chr10 q21.2
Node attribute:	PPI(target); substrate; kinase; gene

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
T161	PIRVYtHEVVT		HPRD
Y15	IGEGTyGVVYK	LYN	HPRD
S178	EVLLGsARYST		HPRD
Y15	IGEGTyGVVYK	PKMYT1	HPRD
S39	KIRLEsEEEGV	Pkinase	PhosphoSitePlus
T14	KIGEGtYGVVY	MYT1	HPRD
T222	FRALGtPNNEV	Pkinase	PhosphoSitePlus
Y160	IPIRVyTHEVV		HPRD
S39	KIRLEsEEEGV	CK2_alpha	phosphoELM
T165	FRALGtPNNEV		HPRD
Y15	IGEGTyGVVYK	Pkinase	PhosphoSitePlus
Y19	TYGVVyKGRHK		HPRD; phosphoELM
Y160	IPIRVyTHEVV	Pkinase	PhosphoSitePlus
Y15	IGEGTyGVVYK		phosphoELM
T5	_MEDYtKIEKI	Pkinase	PhosphoSitePlus
T141	IDDKGtIKLAD	Pkinase	PhosphoSitePlus
Y286	ALNHPyFNDLD	Pkinase	PhosphoSitePlus
T222	FRALGtPNNEV		HPRD
Y19	TYGVVyKGRHK	Pkinase	PhosphoSitePlus
S248	KWKPGsLASHV	Pkinase	PhosphoSitePlus
Y4	__MEDyTKIEK	Pkinase	PhosphoSitePlus
S46	EEGVPsTAIRE	Pkinase	PhosphoSitePlus
S39	KIRLEsEEEGV	CSNK2A1	HPRD
Y77	QDSRLyLIFEF		HPRD
S46	EEGVPsTAIRE		HPRD
Y77	QDSRLyLIFEF	Pkinase	PhosphoSitePlus
S233	WPEVEsLQDYK	Pkinase	PhosphoSitePlus
T161	PIRVYtHEVVT	Pkinase	PhosphoSitePlus
T5	IEKI		HPRD
T14	KIGEGtYGVVY		phosphoELM
Y19	TYGVVyKGRHK	CDK1	HPRD
S121	EVLLGsARYST		HPRD
T161	PIRVYtHEVVT	CDK7	HPRD; phosphoELM
T14	KIGEGtYGVVY	Pkinase	PhosphoSitePlus
T14	KIGEGtYGVVY	PKMYT1	HPRD
Y4	KIEK		HPRD
S39	KIRLEsEEEGV	CK2_group	phosphoELM
Y15	IGEGTyGVVYK	WEE1	HPRD; phosphoELM
Y270	SKMLIyDPAKR	Pkinase	PhosphoSitePlus
S178	EVLLGsARYST	Pkinase	PhosphoSitePlus

Dephosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y15	EKIGEGTyGVVYKGR	CDC25C	HPRD
T14	IEKIGEGtYGVVYKG	CDC25C	HPRD

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000378699	D73H	COSMIC	Ovarian Cancer	21720365

Differential expressed protein

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000378699	Breast Cancer	Normal vs. Cancer	cell line	Up	1.3	20543960

Hyperphosphorylation site

Site	Motif	Peptide	Cancer name	Pubmed	Source
Y15	Pkinase	EKIGEGTyGVVYKGR	cholangiocellular carcinoma	21253578	PhosphoSitePlus

Direct Interaction Pair

Source	Target	Relationship	Resource
CDK1_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD
CDK1_HUMAN	TLE2_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	NDE1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	RAB1A_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	APLP2_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	DLGP5_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	RFA2_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	MPIP3_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK1_HUMAN	RIR2_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	RBBP5_HUMAN	kinase -> substrate	RegPhos
LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	CSK2B_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	KITH_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	UBE2A_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	LBR_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	PTHR_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	PTN2_HUMAN	kinase -> substrate	HPRD
CDK1_HUMAN	TSC1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	FOXM1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	H11_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	ORC1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	NDEL1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	KHDR1_HUMAN	kinase -> substrate	HPRD; RegPhos
PLK1_HUMAN	CDK1_HUMAN	kinase -> substrate	KEGG
CDK1_HUMAN	P3C2A_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	TOP2A_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	KI20B_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	GOGA2_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	APC1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	K2C8_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	STMN2_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	MPIP2_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	ESPL1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	KAT5_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	APC4_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	ANDR_HUMAN	kinase -> substrate	NetPath
CDK1_HUMAN	CREM_HUMAN	kinase -> substrate	RegPhos
WEE1_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
CDK1_HUMAN	MAP4_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	TLE4_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	41_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	PP1A_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	FANCG_HUMAN	kinase -> substrate	HPRD; RegPhos
PMYT1_HUMAN	CDK1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	NPM_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	ITPR1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	SKAP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK1_HUMAN	RAB5B_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	K1C18_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	SYN3_HUMAN	kinase -> substrate	RegPhos
CSK21_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
CDK1_HUMAN	MEF2C_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	CDC23_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	LMNB1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	RB_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	RCC1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	TOPK_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	KIF11_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	RAB4A_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	NSF1C_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	STMN1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	MPIP1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	PITM1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	PTTG1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	KIF22_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	TLE1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	DDX3X_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	PO210_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	EF1D_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	CEP55_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	CDC16_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	GRK5_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK1_HUMAN	VIME_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	FEN1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	NEST_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	DUT_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	PLEC_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	LATS1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	EPN1_HUMAN	kinase -> substrate	HPRD; RegPhos
CHK1_HUMAN	CDK1_HUMAN	kinase -> substrate	KEGG
CDK1_HUMAN	PTN1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	IL16_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	UBA1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	GFAP_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	ECT2_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	RGAP1_HUMAN	kinase -> substrate	HPRD
WEE2_HUMAN	CDK1_HUMAN	kinase -> substrate	KEGG
CDK1_HUMAN	ABL1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	AMPH_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	MYOD1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	KS6B1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	LMNA_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	MCM4_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	CSK21_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	SLBP_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	BUB1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	RGCC_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	WEE1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	P53_HUMAN	kinase -> substrate	RegPhos
CDK7_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
CDK1_HUMAN	PRDX1_HUMAN	kinase -> substrate	RegPhos
ZAGL2_HUMAN	CDK1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	BIRC5_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	RPGP1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK1_HUMAN	CALD1_HUMAN	kinase -> substrate	RegPhos
CDK1_HUMAN	CDC27_HUMAN	kinase -> substrate	RegPhos
PLK1_HUMAN	CDK1_HUMAN	phosphatase -> substrate	KEGG
MPIP1_HUMAN	CDK1_HUMAN	phosphatase -> substrate	KEGG
MPIP3_HUMAN	CDK1_HUMAN	phosphatase -> substrate	HPRD
ORN_HUMAN	CDK1_HUMAN	other	KEGG
GA45G_HUMAN	CDK1_HUMAN	other	KEGG
E2F4_HUMAN	CDK1_HUMAN	TF -> target gene	TRANSFAC
MYB_HUMAN	CDK1_HUMAN	TF -> target gene	TRANSFAC
NFYB_HUMAN	CDK1_HUMAN	TF -> target gene	TRANSFAC
NFYA_HUMAN	CDK1_HUMAN	TF -> target gene	TRANSFAC
ETS2_HUMAN	CDK1_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05169	Epstein-Barr virus infection
hsa04110	Cell cycle
hsa04114	Oocyte meiosis
hsa04914	Progesterone-mediated oocyte maturation
hsa05168	Herpes simplex infection
hsa04540	Gap junction
hsa05203	Viral carcinogenesis
hsa04115	p53 signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0014823	response to activity	IEA	biological_process
GO:0051403	stress-activated MAPK cascade	TAS	biological_process
GO:0002755	MyD88-dependent toll-like receptor signaling pathw	TAS	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pat	TAS	biological_process
GO:0051437	positive regulation of ubiquitin-protein ligase ac	TAS	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0035666	TRIF-dependent toll-like receptor signaling pathwa	TAS	biological_process
GO:0000278	mitotic cell cycle	IEA	biological_process
GO:0016572	histone phosphorylation	IEA	biological_process
GO:0005876	spindle microtubule	IDA	cellular_component
GO:0014070	response to organic cyclic compound	IEA	biological_process
GO:0007067	mitosis	IEA	biological_process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0030544	Hsp70 protein binding	IEA	molecular_function
GO:0055015	ventricular cardiac muscle cell development	IEA	biological_process
GO:0000082	G1/S transition of mitotic cell cycle	TAS	biological_process
GO:0000278	mitotic cell cycle	TAS	biological_process
GO:0000186	activation of MAPKK activity	TAS	biological_process
GO:0008286	insulin receptor signaling pathway	TAS	biological_process
GO:0043066	negative regulation of apoptotic process	IDA	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0031100	organ regeneration	IEA	biological_process
GO:0060045	positive regulation of cardiac muscle cell prolife	IEA	biological_process
GO:0000083	regulation of transcription involved in G1/S phase	TAS	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0048011	nerve growth factor receptor signaling pathway	TAS	biological_process
GO:0007411	axon guidance	TAS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0045995	regulation of embryonic development	TAS	biological_process
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0007569	cell aging	IEA	biological_process
GO:0008543	fibroblast growth factor receptor signaling pathwa	TAS	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	TAS	biological_process
GO:0034130	toll-like receptor 1 signaling pathway	TAS	biological_process
GO:0046688	response to copper ion	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0005739	mitochondrion	TAS	cellular_component
GO:0014038	regulation of Schwann cell differentiation	TAS	biological_process
GO:0070301	cellular response to hydrogen peroxide	IEA	biological_process
GO:0004672	protein kinase activity	NAS	molecular_function
GO:0014075	response to amine stimulus	IEA	biological_process
GO:0005815	microtubule organizing center	IEA	cellular_component
GO:0007264	small GTPase mediated signal transduction	TAS	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0051439	regulation of ubiquitin-protein ligase activity in	TAS	biological_process
GO:0000165	MAPK cascade	TAS	biological_process
GO:0045087	innate immune response	TAS	biological_process
GO:0005524	ATP binding	IEA	molecular_function
GO:0042542	response to hydrogen peroxide	IEA	biological_process
GO:0000226	microtubule cytoskeleton organization	TAS	biological_process
GO:0007095	mitotic cell cycle G2/M transition DNA damage chec	IEA	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	biological_process
GO:0000187	activation of MAPK activity	TAS	biological_process
GO:0031145	anaphase-promoting complex-dependent proteasomal u	TAS	biological_process
GO:0035173	histone kinase activity	IEA	molecular_function
GO:0033160	positive regulation of protein import into nucleus	IEA	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:0045931	positive regulation of mitotic cell cycle	IEA	biological_process
GO:0034501	protein localization to kinetochore	IDA	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0006260	DNA replication	TAS	biological_process
GO:0030332	cyclin binding	IEA	molecular_function
GO:0034138	toll-like receptor 3 signaling pathway	TAS	biological_process
GO:0009636	response to toxin	IEA	biological_process
GO:0016301	kinase activity	IEA	molecular_function
GO:0030261	chromosome condensation	IEA	biological_process
GO:0045740	positive regulation of DNA replication	IEA	biological_process
GO:0008063	Toll signaling pathway	TAS	biological_process
GO:0007265	Ras protein signal transduction	TAS	biological_process
GO:0030496	midbody	IDA	cellular_component
GO:0034142	toll-like receptor 4 signaling pathway	TAS	biological_process
GO:0002224	toll-like receptor signaling pathway	TAS	biological_process
GO:0046686	response to cadmium ion	IEA	biological_process
GO:0007344	pronuclear fusion	TAS	biological_process
GO:0016477	cell migration	TAS	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0007098	centrosome cycle	TAS	biological_process
GO:0051301	cell division	IEA	biological_process
GO:0000086	G2/M transition of mitotic cell cycle	TAS	biological_process
GO:0010628	positive regulation of gene expression	IEA	biological_process
GO:0008353	RNA polymerase II carboxy-terminal domain kinase a	IDA	molecular_function
GO:0000075	cell cycle checkpoint	TAS	biological_process
GO:0010243	response to organic nitrogen	IEA	biological_process
GO:0006461	protein complex assembly	IEA	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0004693	cyclin-dependent protein kinase activity	IDA	molecular_function
GO:0006281	DNA repair	TAS	biological_process
GO:0048678	response to axon injury	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network