Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNF4A_HUMAN
Description:hepatocyte nuclear factor 4, alpha [Source:HGNC Symbol;Acc:5024]
Location:chr20 q13.12
Node attribute:gene; substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S170ITSPVsGINGDFoamy_virus_ENV; Se-cys_sPhosphoSitePlus
S436ETPQPsPPGGSPhosphoSitePlus
S138ERDRIsTRRSSFoamy_virus_ENVPhosphoSitePlus
S143STRRSsYEDSSFoamy_virus_ENVPhosphoSitePlus
S313IKRLRsQVQVSAMPKa2RegPhos
S443PGGSGsEPYKLPhosphoSitePlus
S313IKRLRsQVQVSHormone_recepPhosphoSitePlus
S143STRRSsYEDSSphosphoELM; RegPhos
Y23ALDPAyTTLEFPhosphoSitePlus
T429RGQAAtPETPQRegPhos
S167SRQITsPVSGIp38b(MAPK11RegPhos
S313IKRLRsQVQVSAMPK_groupphosphoELM; RegPhos
S142ISTRRsSYEDSphosphoELM; RegPhos
S167SRQITsPVSGIMAPK11phosphoELM
T432AATPEtPQPSPPhosphoSitePlus; RegPhos
S142ISTRRsSYEDSFoamy_virus_ENVPhosphoSitePlus
S303DAKGLsDPGKIHormone_recepPhosphoSitePlus
S190ADVCEsMKEQLFoamy_virus_ENV; Se-cys_sPhosphoSitePlus
Y288DNEYAyLKAIIHormone_recepPhosphoSitePlus
T469PQPTItKQEVIPhosphoSitePlus; RegPhos
T455PGAVAtIVKPLPhosphoSitePlus
S145SRQITsPVSGIMAPK14HPRD
S147SSYEDsSLPSIFoamy_virus_ENV; Se-cys_sPhosphoSitePlus
S75KHYGAsSCDGCzf-C4; Foamy_virus_ENVPhosphoSitePlus
S151DSSLPsINALLFoamy_virus_ENV; Se-cys_sPhosphoSitePlus
S190ADVCEsMKEQLphosphoELM; RegPhos
S167SRQITsPVSGIp38aRegPhos
T166LSRQItSPVSGFoamy_virus_ENV; Se-cys_sPhosphoSitePlus
S167SRQITsPVSGIFoamy_virus_ENV; Se-cys_sPhosphoSitePlus
S318SQVQVsLEDYIHormone_recepPhosphoSitePlus
S313IKRLRsQVQVSPRKAA2HPRD
S167SRQITsPVSGIMAPK14HPRD
Y72ATGKHyGASSCzf-C4; Foamy_virus_ENVPhosphoSitePlus
Y286IDDNEyAYLKAHormone_recepPhosphoSitePlus
S378MLLGGsPSDAPPhosphoSitePlus
T469PQPTItKQEphosphoELM
S76HYGASsCDGCKzf-C4; Foamy_virus_ENVPhosphoSitePlus

Dephosphorylation site
HNF4A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312987Q164*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000312987M125IBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000312987N49ICOSMICLung Cancer
ENSP00000312987M394ICOSMICMelanoma

Differential expressed protein
HNF4A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HNF4A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANHNF4A_HUMANkinase -> substrateHPRD
ZAGL2_HUMANHNF4A_HUMANkinase -> substrateRegPhos
MK11_HUMANHNF4A_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANHNF4A_HUMANkinase -> substrateHPRD; RegPhos
HNF4A_HUMANSHBG_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANCP8B1_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANEPO_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANCP27A_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANAMBP_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANCEAM1_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANHGFL_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANPPARA_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANFA10_HUMANTF -> target geneTRANSFAC
GATA6_HUMANHNF4A_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANANT3_HUMANTF -> target geneTRANSFAC
SP1_HUMANHNF4A_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANHNF4A_HUMANTF -> target geneTRANSFAC
HNF6_HUMANHNF4A_HUMANTF -> target geneTRANSFAC
COT2_HUMANHNF4A_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANTHRB_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANFA11_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANCP2D6_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANFA7_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANSTAR_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANGLPK_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANHMOX1_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANCP2C9_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANAPOC3_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANCP3A4_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANFA12_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANAK1C4_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANAPOB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04950Maturity onset diabetes of the young

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0031018endocrine pancreas developmentTASbiological_process
GO:0030308negative regulation of cell growthIMPbiological_process
GO:0007596blood coagulationIDAbiological_process
GO:0005504fatty acid bindingIDAmolecular_function
GO:0050796regulation of insulin secretionIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:2000189positive regulation of cholesterol homeostasisISSbiological_process
GO:0070328triglyceride homeostasisISSbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
GO:0050796regulation of insulin secretionISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region seISSmolecular_function
GO:0055091phospholipid homeostasisIEAbiological_process
GO:0009749response to glucose stimulusISSbiological_process
GO:0019216regulation of lipid metabolic processIDAbiological_process
GO:0055091phospholipid homeostasisISSbiological_process
GO:0042593glucose homeostasisISSbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0070328triglyceride homeostasisIEAbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0055088lipid homeostasisIMPbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0007548sex differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005102receptor bindingIDAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0060398regulation of growth hormone receptor signaling paNASbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0033613activating transcription factor bindingISSmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0023019signal transduction involved in regulation of geneIEAbiological_process
GO:0006805xenobiotic metabolic processIMPbiological_process
GO:0033613activating transcription factor bindingIEAmolecular_function
GO:0010470regulation of gastrulationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:2000189positive regulation of cholesterol homeostasisIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0006591ornithine metabolic processIMPbiological_process