Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STA5B_HUMAN
Description:signal transducer and activator of transcription 5B [Source:HGNC Symbol;Acc:11367]
Location:chr17 q21.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T684YSKYYtPVPCEPhosphoSitePlus
Y699KAVDGyVKPQIJAK1RegPhos
Y699KAVDGyVKPQIHCKphosphoELM; RegPhos
S375KATIIsEQQAKSTAT_bindPhosphoSitePlus
Y90IKLGHyATQLQSTAT_intPhosphoSitePlus
Y743AHYNMyPQNPDPhosphoSitePlus
T692PCESAtAKAVDPhosphoSitePlus
Y725GGSATyMDQAPEGFRHPRD; phosphoELM; RegPhos
Y743AHYNMyPQNPDEGFRHPRD; phosphoELM; RegPhos
Y668LNYLIyVFPDRSH2PhosphoSitePlus
S655DFSIRsLADRLHPRD
Y740CPQAHyNMYPQEGFRHPRD; phosphoELM; RegPhos
S193PLAQLsPQERLSTAT_alphaPhosphoSitePlus; SysPTM
Y665LGDLNyLIYVFSH2PhosphoSitePlus
Y679PKDEVySKYYTSRCHPRD; phosphoELM; RegPhos
Y683VYSKYyTPVPCPhosphoSitePlus
Y668LNYLIyVFPDRHPRD
S193PLAQLsPQERLHPRD; phosphoELM; RegPhos; SysPTM
Y725GGSATyMDQAPPhosphoSitePlus
S127EANNGsSPAGSHPRD; phosphoELM; SysPTM
Y90IKLGHyATQLQHPRD; phosphoELM; RegPhos
Y740CPQAHyNMYPQPhosphoSitePlus
Y98QLQNTyDRCPMHPRD
S731MDQAPsPAVCPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S132SSPAGsLADAMPhosphoSitePlus; HPRD
Y114IRHILyNEQRLSTAT_intPhosphoSitePlus
T92LGHYAtQLQNTSTAT_intPhosphoSitePlus
T245LRKQQtIILDDSTAT_alphaPhosphoSitePlus
S128ANNGSsPAGSLPhosphoSitePlus; HPRD; SysPTM
Y679PKDEVySKYYTSrcRegPhos
T372PQVKAtIISEQSTAT_bindPhosphoSitePlus
Y699KAVDGyVKPQIPhosphoSitePlus; phosphoELM
Y682EVYSKyYTPVPPhosphoSitePlus
Y392NTRNDySGEILSTAT_bindPhosphoSitePlus
Y699KAVDGyVKPQIEGFRHPRD; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y699TAKAVDGyVKPQIKQPTPN1HPRD
Y699TAKAVDGyVKPQIKQPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000293328N609KCOSMICOvarian Cancer21720365
ENSP00000293328L412FDing2008, COSMICLung Cancer18948947
ENSP00000293328A91SCOSMICOvarian Cancer21720365
ENSP00000293328L643VCOSMICOvarian Cancer21720365
ENSP00000293328G592VDing2008, COSMICLung Cancer18948947
ENSP00000293328I144FCOSMICHead and Neck Cancer21798893

Differential expressed protein
STA5B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S193STAT_alphaFGPLAQLsPQERLSRacute lymphocytic leukemia; acute myelogenous leukemia; B cell lymphoma22442148PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
HCK_HUMANSTA5B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BTK_HUMANSTA5B_HUMANkinase -> substrateRobert H Newman (2013)
JAK1_HUMANSTA5B_HUMANkinase -> substrateRegPhos
KIT_HUMANSTA5B_HUMANkinase -> substrateNetPath
ZAGL2_HUMANSTA5B_HUMANkinase -> substrateRegPhos
SRC_HUMANSTA5B_HUMANkinase -> substrateHPRD; RegPhos
EGFR_HUMANSTA5B_HUMANkinase -> substrateRegPhos
PTN11_HUMANSTA5B_HUMANphosphatase -> substrateHPRD; NetPath
PTN1_HUMANSTA5B_HUMANphosphatase -> substrateHPRD
STA5B_HUMANCCND1_HUMANTF -> target geneTRANSFAC
STA5B_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STA5B_HUMANCDN1A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04012ErbB signaling pathway
hsa05221Acute myeloid leukemia
hsa04062Chemokine signaling pathway
hsa05203Viral carcinogenesis
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa04630Jak-STAT signaling pathway
hsa05220Chronic myeloid leukemia
hsa05162Measles

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0032870cellular response to hormone stimulusIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0045954positive regulation of natural killer cell mediateIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0007548sex differentiationIEAbiological_process
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0019530taurine metabolic processIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0051272positive regulation of cellular component movementIEAbiological_process
GO:00061032-oxoglutarate metabolic processIEAbiological_process
GO:0007565female pregnancyIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0006105succinate metabolic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005509calcium ion bindingIEAmolecular_function
GO:0001553luteinizationIEAbiological_process
GO:0035259glucocorticoid receptor bindingIPImolecular_function
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0006107oxaloacetate metabolic processIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0045086positive regulation of interleukin-2 biosynthetic IEAbiological_process
GO:0006549isoleucine metabolic processIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0006600creatine metabolic processIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0040014regulation of multicellular organism growthISSbiological_process
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0019915lipid storageIEAbiological_process
GO:0046449creatinine metabolic processIEAbiological_process
GO:0045931positive regulation of mitotic cell cycleIEAbiological_process
GO:0042448progesterone metabolic processIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0019218regulation of steroid metabolic processIEAbiological_process
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0032825positive regulation of natural killer cell differeIEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0030856regulation of epithelial cell differentiationIEAbiological_process
GO:0006101citrate metabolic processIEAbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0070669response to interleukin-2IEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0042104positive regulation of activated T cell proliferatIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045579positive regulation of B cell differentiationIEAbiological_process
GO:0007259JAK-STAT cascadeIEAbiological_process
GO:0045647negative regulation of erythrocyte differentiationIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0046543development of secondary female sexual characterisIEAbiological_process
GO:0045621positive regulation of lymphocyte differentiationIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0006573valine metabolic processIEAbiological_process
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0070670response to interleukin-4IEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007595lactationIEAbiological_process
GO:0045588positive regulation of gamma-delta T cell differenIEAbiological_process
GO:0032819positive regulation of natural killer cell prolifeIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0000255allantoin metabolic processIEAbiological_process
GO:0006953acute-phase responseIEAbiological_process
GO:0046544development of secondary male sexual characteristiIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0070672response to interleukin-15IEAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process