Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RIPK3_HUMAN
Description:receptor-interacting serine-threonine kinase 3 [Source:HGNC Symbol;Acc:10021]
Location:chr14 q12
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S372SLTKRsRAQEEPhosphoSitePlus
S227LPTEPsLVYEAPkinasePhosphoSitePlus
S410RNQMPsPTSTGPhosphoSitePlus
T325SGQGGtEMDGFPhosphoSitePlus
S339IENQHsRNDVMPhosphoSitePlus
S320FSIPEsGQGGTPhosphoSitePlus
T412QMPSPtSTGTPPhosphoSitePlus
T398AQPPQtPETSTPhosphoSitePlus
S359LEEPPsSVPKKPhosphoSitePlus
S316SNRRFsIPESGPhosphoSitePlus

Dephosphorylation site
RIPK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216274A13VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000216274Gastric CancerMetastasiscell lineDown0.5817022644
ENSP00000216274Gastric CancerMetastasiscell lineDown0.5817022644

Hyperphosphorylation site
RIPK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
MK07_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANRIPK1_HUMANkinase -> substrateNetPath
RIPK3_HUMANF16P1_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
KCC2B_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
HIPK1_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANPLMN_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
SNRK_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04623Cytosolic DNA-sensing pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051260protein homooligomerizationIDAbiological_process
GO:0097190apoptotic signaling pathwayTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0060545positive regulation of necroptosisIMPbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0051291protein heterooligomerizationIDAbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0006464cellular protein modification processTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0007249I-kappaB kinase/NF-kappaB cascadeIEAbiological_process
GO:0038061NIK/NF-kappaB cascadeIEAbiological_process
GO:0004704NF-kappaB-inducing kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006917induction of apoptosisIEAbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0032147activation of protein kinase activityIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0004672protein kinase activityIEAmolecular_function


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