| UniProt/SwissProt ID: | RIPK3_HUMAN |
| Description: | receptor-interacting serine-threonine kinase 3 [Source:HGNC Symbol;Acc:10021] |
| Location: | chr14 q12 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S372 | SLTKRsRAQEE | PhosphoSitePlus | |
| S227 | LPTEPsLVYEA | Pkinase | PhosphoSitePlus |
| S410 | RNQMPsPTSTG | PhosphoSitePlus | |
| T325 | SGQGGtEMDGF | PhosphoSitePlus | |
| S339 | IENQHsRNDVM | PhosphoSitePlus | |
| S320 | FSIPEsGQGGT | PhosphoSitePlus | |
| T412 | QMPSPtSTGTP | PhosphoSitePlus | |
| T398 | AQPPQtPETST | PhosphoSitePlus | |
| S359 | LEEPPsSVPKK | PhosphoSitePlus | |
| S316 | SNRRFsIPESG | PhosphoSitePlus | |
| Dephosphorylation site |
| RIPK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000216274 | A13V | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000216274 | Gastric Cancer | Metastasis | cell line | Down | 0.58 | 17022644 | ENSP00000216274 | Gastric Cancer | Metastasis | cell line | Down | 0.58 | 17022644 |
| Hyperphosphorylation site |
| RIPK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K7_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK07_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ACVR1_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | RIPK1_HUMAN | kinase -> substrate | NetPath |
| RIPK3_HUMAN | F16P1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC2D_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MYLK2_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TBK1_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK1_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ILK_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | E2AK2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC2B_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK2_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K4_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | BAD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | NFAC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | PLMN_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR4_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | MK01_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RIPK3_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SNRK_HUMAN | RIPK3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04623 | Cytosolic DNA-sensing pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051260 | protein homooligomerization | IDA | biological_process |
| GO:0097190 | apoptotic signaling pathway | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0060545 | positive regulation of necroptosis | IMP | biological_process |
| GO:0051092 | positive regulation of NF-kappaB transcription fac | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0051291 | protein heterooligomerization | IDA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0006464 | cellular protein modification process | TAS | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | IEA | biological_process |
| GO:0038061 | NIK/NF-kappaB cascade | IEA | biological_process |
| GO:0004704 | NF-kappaB-inducing kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006917 | induction of apoptosis | IEA | biological_process |
| GO:0032481 | positive regulation of type I interferon productio | TAS | biological_process |
| GO:0032147 | activation of protein kinase activity | IMP | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |