Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYC_HUMAN
Description:v-myc myelocytomatosis viral oncogene homolog (avian) [Source:HGNC Symbol;Acc:7553]
Location:chr8 q24.21
Node attribute:TF; PPI(target); PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T58FELLPtPPLSPGSK3B(GSK3 betaRegPhos
T58FELLPtPPLSPCK2a2RegPhos
T58FELLPtPPLSPGSK3A(GSK3 alphaRegPhos
S249TPPTTsSDSEEMyc_N; TRHPhosphoSitePlus
S252TTSSDsEEEQEMyc_N; TRHPhosphoSitePlus
S363TSPRSsDTEENHPRD
S250PPTTSsDSEEEMyc_N; TRHPhosphoSitePlus
T400ILKKAtAYILSHLHPhosphoSitePlus
S62PTPPLsPSRRSMAPK1phosphoELM
T58FELLPtPPLSPGSK3BRegPhos
T58FELLPtPPLSPMyc_NPhosphoSitePlus
S88GLCSPsYVAVTHPRD
S62PTPPLsPSRRSErk2(MAPK1RegPhos
T8LNVSFtNRNYDMyc_NPhosphoSitePlus
S347CTSPRsSDTEEPhosphoSitePlus
Y16NYDLDyDSVQPMyc_NPhosphoSitePlus
S288SAGGHsKPPHSMyc_N; TRHPhosphoSitePlus
S293SKPPHsPLVLKMyc_NPhosphoSitePlus
S71RSGLCsPSYVAJNK1RegPhos
S337VLRQIsNNRKCMyc_NPhosphoSitePlus
T365PRSSDtEENVKHPRD
T58FELLPtPPLSPGSK-3_betaphosphoELM
T58FELLPtPPLSPCK2a1RegPhos
T58FELLPtPPLSPphosphoELM; RegPhos
S71RSGLCsPSYVAMyc_NPhosphoSitePlus
S359NRKCTsPRSSDHPRD
T358NVKRRtHNVLEHLHPhosphoSitePlus
S21MPLNVsFTNRNHPRD
S64PPLSPsRRSGLMyc_NPhosphoSitePlus
S176RKDSGsPNPARHPRD
S67SPSRRsGLCSPMyc_NPhosphoSitePlus
S79PPLSPsRRSGLHPRD
S86RSGLCsPSYVAMAPK8HPRD
T73FELLPtPPLSPCSNK2A1HPRD
T73FELLPtPPLSPCSNK2A2HPRD
S62PTPPLsPSRRSJNK1RegPhos
S373NELKRsFFALRHLHPhosphoSitePlus
S77PTPPLsPSRRSMAPK8HPRD
T73FELLPtPPLSPGSK3BHPRD
S62PTPPLsPSRRSMyc_NPhosphoSitePlus
S405TAYILsVQAEEHLHPhosphoSitePlus
S348TSPRSsDTEENPhosphoSitePlus
T8LNVSFtNRNYDRAF_groupRegPhos
S161RKDSGsPNPARMyc_NPhosphoSitePlus
T58FELLPtPPLSPGSK-3_groupphosphoELM
T58FELLPtPPLSPCK2a1-rsRegPhos
T58FELLPtPPLSPGSK_groupRegPhos
T58FELLPtPPLSPGSK-3_alphaphosphoELM
S279GKRSEsGSPSAMyc_N; TRHPhosphoSitePlus
S6MPLNVsFTNRNMyc_NPhosphoSitePlus
S344NRKCTsPRSSDMyc_NPhosphoSitePlus
S62PTPPLsPSRRSphosphoELM; RegPhos
S71RSGLCsPSYVAphosphoELM
T343NNRKCtSPRSSMyc_NPhosphoSitePlus

Dephosphorylation site
MYC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367207S265IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000367207Uterine CancerTreatment(none vs. 5-Fluorouracil treatment)cell lineDown15585135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S62Myc_NLLPTPPLsPSRRSGLacute lymphocytic leukemia; chronic myelogenous leukemia; leukemia16855632PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANMYC_HUMANkinase -> substrateKEGG; Robert H Newman (2013)
GSK3A_HUMANMYC_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CSK22_HUMANMYC_HUMANkinase -> substrateHPRD
MK08_HUMANMYC_HUMANkinase -> substrateRegPhos
GSK3B_HUMANMYC_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANMYC_HUMANkinase -> substrateRegPhos
CSK21_HUMANMYC_HUMANkinase -> substrateHPRD
ZHX2_HUMANMYC_HUMANkinase -> substrateRegPhos
MYC_HUMANCCND1_HUMANotherKEGG
MYC_HUMANCDN2B_HUMANotherKEGG
LEF1_HUMANMYC_HUMANotherKEGG
MYC_HUMANZBT17_HUMANotherKEGG
STAT1_HUMANMYC_HUMANTF -> target geneKEGG
LEF1_HUMANMYC_HUMANTF -> target geneKEGG
SOS1_HUMANMYC_HUMANTF -> target geneKEGG
NDKB_HUMANMYC_HUMANTF -> target geneTRANSFAC
MYC_HUMANCXCR4_HUMANTF -> target geneTRANSFAC
CTCF_HUMANMYC_HUMANTF -> target geneTRANSFAC
PO2F2_HUMANMYC_HUMANTF -> target geneTRANSFAC
MYC_HUMANCDK4_HUMANTF -> target geneTRANSFAC
AP2A_HUMANMYC_HUMANTF -> target geneTRANSFAC
MYC_HUMANTERT_HUMANTF -> target geneTRANSFAC
MYC_HUMANDCOR_HUMANTF -> target geneTRANSFAC
USF1_HUMANMYC_HUMANTF -> target geneTRANSFAC
FUBP1_HUMANMYC_HUMANTF -> target geneTRANSFAC
MYC_HUMANDDX18_HUMANTF -> target geneTRANSFAC
MYC_HUMANYBOX1_HUMANTF -> target geneTRANSFAC
SP1_HUMANMYC_HUMANTF -> target geneTRANSFAC
MYC_HUMANMPIP1_HUMANTF -> target geneTRANSFAC
MYC_HUMANMYC_HUMANTF -> target geneTRANSFAC
STAT3_HUMANMYC_HUMANTF -> target geneTRANSFAC
MYC_HUMANERBB2_HUMANTF -> target geneTRANSFAC
STAT4_HUMANMYC_HUMANTF -> target geneTRANSFAC
HNRPK_HUMANMYC_HUMANTF -> target geneTRANSFAC
MAZ_HUMANMYC_HUMANTF -> target geneTRANSFAC
MYC_HUMANIF4E_HUMANTF -> target geneTRANSFAC
ZBT7A_HUMANMYC_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANMYC_HUMANTF -> target geneTRANSFAC
CNBP_HUMANMYC_HUMANTF -> target geneTRANSFAC
ENOA_HUMANMYC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa05202Transcriptional misregulation in cancer
hsa05166HTLV-I infection
hsa04010MAPK signaling pathway
hsa04110Cell cycle
hsa05213Endometrial cancer
hsa04310Wnt signaling pathway
hsa05210Colorectal cancer
hsa04630Jak-STAT signaling pathway
hsa05222Small cell lung cancer
hsa05221Acute myeloid leukemia
hsa04012ErbB signaling pathway
hsa05219Bladder cancer
hsa04350TGF-beta signaling pathway
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmIDAcellular_component
GO:0002053positive regulation of mesenchymal cell proliferatISSbiological_process
GO:2001220negative regulation of G2 phase of mitotic cell cyIDAbiological_process
GO:0010332response to gamma radiationIDAbiological_process
GO:0005819spindleIEAcellular_component
GO:0044346fibroblast apoptotic processTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0006879cellular iron ion homeostasisIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0043280positive regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0042493response to drugIEPbiological_process
GO:0048147negative regulation of fibroblast proliferationIDAbiological_process
GO:0032873negative regulation of stress-activated MAPK cascaISSbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0051276chromosome organizationIDAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0051782negative regulation of cell divisionIDAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0045656negative regulation of monocyte differentiationIMPbiological_process
GO:0006112energy reserve metabolic processNASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0043234protein complexIDAcellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0005730nucleolusIDAcellular_component
GO:2000573positive regulation of DNA biosynthetic processIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0032204regulation of telomere maintenanceIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0015671oxygen transportNASbiological_process
GO:0090096positive regulation of metanephric cap mesenchymalISSbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0000165MAPK cascadeIMPbiological_process
GO:0070848response to growth factor stimulusTASbiological_process
GO:0032403protein complex bindingIDAmolecular_function
GO:2001022positive regulation of response to DNA damage stimIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0048146positive regulation of fibroblast proliferationIMPbiological_process
GO:0070491repressing transcription factor bindingIPImolecular_function
GO:0050679positive regulation of epithelial cell proliferatiIDAbiological_process
GO:0006338chromatin remodelingIDAbiological_process
GO:0035690cellular response to drugIDAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0034644cellular response to UVIEPbiological_process