Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANDR_HUMAN
Description:androgen receptor [Source:HGNC Symbol;Acc:644]
Location:chrX q12
Node attribute:gene; deacetylation(target); acetylation(target); ubiquitination(target); sumoylation(target); subst

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S208SEGSSsGRAREAKT1HPRD
S16YPRPPsKTYRGHPRD; phosphoELM; RegPhos
S206SEGSSsGRAREAKT1RegPhos
S94QGEDGsPQAHRAndrogen_recepPhosphoSitePlus
Y534SYSGPyGDMRLCSKRegPhos
S213RAREAsGAPTSAndrogen_recepPhosphoSitePlus
Y267RGDCMyAPLLGCSKRegPhos
Y307EDTAEySPFKGCSKRegPhos
S258ALEHLsPGEQLHPRD
Y357DEAAAyQSRDYCSKRegPhos
Y915KVKPIyFHTQ_PhosphoSitePlus
T850KRKNPtSCSRRHormone_recepPhosphoSitePlus
S96QGEDGsPQAHRHPRD
S310DTAEYsPFKGGHPRD
S792RMRHLsQEFGWAKT1HPRD
Y551VLPIDyYFPPQCSKRegPhos
Y362YQSRDyYNFPLCSKRegPhos
S424AAGPGsGSPSAHPRD
Y346STLSLyKSGALCSKRegPhos
Y357DEAAAyQSRDYAndrogen_recepPhosphoSitePlus
Y551VLPIDyYFPPQPhosphoSitePlus
S515RVPYPsPTCVKPhosphoSitePlus; phosphoELM; RegPhos
S81QQQETsPRQQQAndrogen_recepPhosphoSitePlus
S213RAREAsGAPTSAKT1RegPhos
Y223SSKDNyLGGTSCSKRegPhos
Y363QSRDYyNFPLAAndrogen_recepPhosphoSitePlus
S791RMRHLsQEFGWAKT_groupRegPhos
S791RMRHLsQEFGWPKB_groupphosphoELM
T280PAVRPtPCAPLAndrogen_recepPhosphoSitePlus
Y363QSRDYyNFPLACSKRegPhos
Y534SYSGPyGDMRLPhosphoSitePlus
S308DTAEYsPFKGGphosphoELM; RegPhos
S83QQQETsPRQQQHPRD
Y393ENPLDyGSAWAAndrogen_recepPhosphoSitePlus
S215RAREAsGAPTSAKT1HPRD
Y223SSKDNyLGGTSAndrogen_recepPhosphoSitePlus
S578ALTCGsCKVFFzf-C4PhosphoSitePlus
Y346STLSLyKSGALAndrogen_recepPhosphoSitePlus
S81QQQETsPRQQQphosphoELM; RegPhos
S651ASSTTsPTEETHPRD
S791RMRHLsQEFGWHormone_recepPhosphoSitePlus
S231GTSTIsDNAKEAndrogen_recepPhosphoSitePlus
S302DSAGKsTEDTAHPRD
S244KAVSVsMGLGVAndrogen_recepPhosphoSitePlus
S424GPGSGsPSAAAAndrogen_recepPhosphoSitePlus
S291AECKGsLLDDSAndrogen_recepPhosphoSitePlus
S94QGEDGsPQAHRphosphoELM; RegPhos
S119ASSTTsPTEETHPRD
S791RMRHLsQEFGWAKT1RegPhos
Y267RGDCMyAPLLGAndrogen_recepPhosphoSitePlus
S260RMRHLsQEFGWAKT1HPRD
Y915KVKPIyFHTQCSKRegPhos
R405AAAQCrYGDLAAndrogen_recepPhosphoSitePlus
Y362YQSRDyYNFPLAndrogen_recepPhosphoSitePlus
S424GPGSGsPSAAAphosphoELM; RegPhos
S256ALEHLsPGEQLphosphoELM; RegPhos
S16YPRPPsKTYRGAndrogen_recepPhosphoSitePlus
S119PSQPQsALECHRegPhos
Y307EDTAEySPFKGAndrogen_recepPhosphoSitePlus
T217ASGAPtSSKDNAndrogen_recepPhosphoSitePlus
S650ASSTTsPTEETPhosphoSitePlus; phosphoELM; RegPhos
S213RAREAsGAPTSAKT_groupRegPhos
S213RAREAsGAPTSPKB_groupphosphoELM
S308DTAEYsPFKGGAndrogen_recepPhosphoSitePlus
Y857CSRRFyQLTKLHormone_recepPhosphoSitePlus
Y393ENPLDyGSAWACSKRegPhos
S256ALEHLsPGEQLAndrogen_recepPhosphoSitePlus
S516RVPYPsPTCVKMAPK1HPRD
S300DSAGKsTEDTARegPhos
S242LCKAVsVSMGLAndrogen_recepPhosphoSitePlus

Dephosphorylation site
ANDR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363822L729ITCGAOvarian Cancer21720365, 18772890
ENSP00000363822P724TCOSMICOvarian Cancer20668451
ENSP00000363822E355KCOSMICBreast Cancer20668451
ENSP00000363822E682KCOSMICLung Cancer20668451
ENSP00000379358F282VBIOMARTGastric Cancer21930507, 21930502
ENSP00000363822P613LCOSMICLung Cancer20668451
ENSP00000363822C290YBIOMARTBreast Cancer21930507, 21930502
ENSP00000363822N235KCOSMICOvarian Cancer20668451
ENSP00000363822L729ICOSMICOvarian Cancer21720365
ENSP00000363822E794DBIOMARTGastric Cancer21930507, 21930502
ENSP00000363822D840NCOSMICBreast Cancer20668451

Differential expressed protein
ANDR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y534MDSYSGPyGDMRLETprostate cancer17045208PhosphoSitePlus
S81Androgen_recepQQQQQETsPRQQQQQprostate cancer21799006PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANANDR_HUMANkinase -> substrateRegPhos
GSK3B_HUMANANDR_HUMANkinase -> substrateNetPath
CDK9_HUMANANDR_HUMANkinase -> substrateNetPath
CSK_HUMANANDR_HUMANkinase -> substrateRegPhos
CDK1_HUMANANDR_HUMANkinase -> substrateNetPath
CDK5_HUMANANDR_HUMANkinase -> substrateNetPath
MK01_HUMANANDR_HUMANkinase -> substrateHPRD
PAK6_HUMANANDR_HUMANkinase -> substrateNetPath
AKT1_HUMANANDR_HUMANkinase -> substrateRegPhos; NetPath
IPYR_HUMANANDR_HUMANphosphatase -> substrateNetPath
RNF6_HUMANANDR_HUMANubiquitinationNetPath
MDM2_HUMANANDR_HUMANubiquitinationNetPath
UBC9_HUMANANDR_HUMANsumoylationNetPath
KAT2B_HUMANANDR_HUMANacetylationNetPath
KAT5_HUMANANDR_HUMANacetylationNetPath
EP300_HUMANANDR_HUMANacetylationNetPath
HDAC1_HUMANANDR_HUMANdeacetylationNetPath
CASP7_HUMANANDR_HUMANotherNetPath
CASP8_HUMANANDR_HUMANotherNetPath
CASP3_HUMANANDR_HUMANotherNetPath
CASP1_HUMANANDR_HUMANotherNetPath
ANDR_HUMANPIGR_HUMANTF -> target geneTRANSFAC
ANDR_HUMANFA9_HUMANTF -> target geneTRANSFAC
ANDR_HUMANANDR_HUMANTF -> target geneTRANSFAC
ANDR_HUMANKLK3_HUMANTF -> target geneTRANSFAC
ANDR_HUMANCDN1A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030522intracellular receptor mediated signaling pathwayIDAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0009987cellular processIEAbiological_process
GO:0004882androgen receptor activityNASmolecular_function
GO:0030850prostate gland developmentNASbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0090003regulation of establishment of protein localizatioIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0008013beta-catenin bindingIDAmolecular_function
GO:0030521androgen receptor signaling pathwayIEAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0071383cellular response to steroid hormone stimulusIEAbiological_process
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0005497androgen bindingNASmolecular_function
GO:0051259protein oligomerizationIDAbiological_process
GO:0060520activation of prostate induction by androgen recepIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0043234protein complexIDAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0016049cell growthNASbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0045720negative regulation of integrin biosynthetic proceIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0060740prostate gland epithelium morphogenesisIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0070974POU domain bindingIEAmolecular_function
GO:0050790regulation of catalytic activityIEAbiological_process
GO:0005496steroid bindingIEAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0060748tertiary branching involved in mammary gland duct IEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0030424axonIEAcellular_component
GO:0060685regulation of prostatic bud formationIEAbiological_process
GO:0005497androgen bindingIEAmolecular_function
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0004879ligand-activated sequence-specific DNA binding RNAIDAmolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0003677DNA bindingNASmolecular_function
GO:0019899enzyme bindingIEAmolecular_function
GO:0003073regulation of systemic arterial blood pressureIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0045726positive regulation of integrin biosynthetic proceIDAbiological_process
GO:0006810transportTASbiological_process
GO:0060736prostate gland growthIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0048638regulation of developmental growthIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIDAbiological_process
GO:0048808male genitalia morphogenesisIEAbiological_process
GO:0060742epithelial cell differentiation involved in prostaIEAbiological_process
GO:0046661male sex differentiationIEAbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0010468regulation of gene expressionIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:0008219cell deathIEAbiological_process
GO:0048645organ formationIEAbiological_process
GO:0060571morphogenesis of an epithelial foldIEAbiological_process
GO:0060599lateral sprouting involved in mammary gland duct mIEAbiological_process
GO:0033148positive regulation of intracellular estrogen receIEAbiological_process
GO:0045945positive regulation of transcription from RNA polyIDAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0008283cell proliferationNASbiological_process
GO:0043568positive regulation of insulin-like growth factor IEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0046983protein dimerization activityNASmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0042327positive regulation of phosphorylationIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0019102male somatic sex determinationIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0007548sex differentiationNASbiological_process
GO:0030521androgen receptor signaling pathwayIDAbiological_process
GO:0048608reproductive structure developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0050681androgen receptor bindingIEAmolecular_function