Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCG1_HUMAN
Description:phospholipase C, gamma 1 [Source:HGNC Symbol;Acc:9065]
Location:chr20 q12
Node attribute:PPI(source); Enzyme(target); Enzyme(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S981CYRDMsSFPETPI-PLC-YPhosphoSitePlus
Y1253SFESRyQQPFEPDGFR_groupRegPhos; SysPTM
Y977TERACyRDMSSHPRD; phosphoELM; RegPhos
S954IALELsELVVYPI-PLC-YPhosphoSitePlus
Y472AEGSAyEEVPTPhosphoSitePlus; phosphoELM
S470KLAEGsAYEEVPhosphoSitePlus
Y481PTSMMySENDIPhosphoSitePlus; HPRD; RegPhos
Y833WWRGDyGGKKQSH3_1PhosphoSitePlus
Y379GMPVIyHGHTLPI-PLC-XPhosphoSitePlus
Y991TKAEKyVNKAKPI-PLC-YPhosphoSitePlus
Y771TAEPDyGALYESykRegPhos; SysPTM
Y977TERACyRDMSSPI-PLC-YPhosphoSitePlus
Y771TAEPDyGALYESYKHPRD; phosphoELM; RegPhos; SysPTM
T791ANPMPtFKCAVPhosphoSitePlus; HPRD
Y1253SFESRyQQPFEFGFR1RegPhos; SysPTM
S1236RGSDAsGQLFHPhosphoSitePlus
S982YRDMSsFPETKPI-PLC-YPhosphoSitePlus
Y93RDFDRyQEDPAPHPhosphoSitePlus
Y783RNPGFyVEANPRETHPRD; RegPhos; SysPTM
Y186LSQVNyRVPNMEF_hand_4PhosphoSitePlus
Y518TSSKIyYSEETPHPhosphoSitePlus
Y1253SFESRyQQPFEFGFR_groupRegPhos; SysPTM
S1248RAREGsFESRYPRKD1HPRD
T766LEKIGtAEPDYPhosphoSitePlus
Y1253SFESRyQQPFEEGFRphosphoELM; RegPhos; SysPTM
S1248RAREGsFESRYPKD1RegPhos
S1248RAREGsFESRYPhosphoSitePlus
Y472AEGSAyEEVPTEGFRHPRD; RegPhos
T237FLEAStLRAGEPhosphoSitePlus
Y775DYGALyEGRNPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y702NEPNSyAISFRSH2PhosphoSitePlus
Y771TAEPDyGALYEPDGFR_groupRegPhos; SysPTM
S525SEETSsDQGNEHPRD
Y669ESKEWyHASLTSH2PhosphoSitePlus
Y771TAEPDyGALYEEGFRHPRD; phosphoELM; RegPhos; SysPTM
S1251EGSFEsRYQQPPhosphoSitePlus
Y506VNHEWyPHYFVPHPhosphoSitePlus
Y783RNPGFyVEANPFGFR_groupRegPhos; SysPTM
S1263EDFRIsQEHLAPhosphoSitePlus; HPRD; phosphoELM
Y783RNPGFyVEANPSYKHPRD; phosphoELM; RegPhos; SysPTM
Y783RNPGFyVEANPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S219AQLYRsLMYSAPhosphoSitePlus
Y959SELVVyCRPVPPI-PLC-YPhosphoSitePlus
Y1253SFESRyQQPFEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1248RAREGsFESRYPKA_groupphosphoELM; RegPhos
Y472AEGSAyEEVPTFGFR1RegPhos
T1226SPFSGtSLRERPhosphoSitePlus
Y506VNHEWyPHYFVRegPhos
Y379GMPVIyHGHTLRegPhos
Y783RNPGFyVEANPLYNHPRD; RegPhos; SysPTM
Y783RNPGFyVEANPEGFRHPRD; phosphoELM; RegPhos; SysPTM
Y771TAEPDyGALYEFGFR1RegPhos; SysPTM
S1224DLSPFsGTSLRPhosphoSitePlus
Y783RNPGFyVEANPHCKHPRD; RegPhos; SysPTM
Y771TAEPDyGALYEFGFR_groupRegPhos; SysPTM
Y771TAEPDyGALYELYNHPRD; RegPhos; SysPTM
S412YPVILsIEDHCPI-PLC-XPhosphoSitePlus
Y496KNGILyLEDPVPHPhosphoSitePlus
Y210SGDITyGQFAQPhosphoSitePlus
Y509EWYPHyFVLTSPHPhosphoSitePlus
S1227PFSGTsLRERGPhosphoSitePlus
Y771TAEPDyGALYESkyRegPhos; SysPTM
S1248RAREGsFESRYPKC_alphaphosphoELM
S1233LRERGsDASGQPhosphoSitePlus; HPRD; phosphoELM
Y771TAEPDyGALYEHCKHPRD; RegPhos; SysPTM
Y428RNMAQyFKKVLPI-PLC-XPhosphoSitePlus
S1221ENGDLsPFSGTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y771TAEPDyGALYEPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
Y783RNPGFyVEANPPDGFR_groupRegPhos; SysPTM
T477YEEVPtSMMYSPhosphoSitePlus
S6CANGHPRD
Y1253SFESRyQQPFEHCKHPRD; RegPhos; SysPTM
Y783RNPGFyVEANPSykRegPhos; SysPTM
Y783RNPGFyVEANPFGFR1RegPhos; SysPTM
S1248RAREGsFESRYPKCa(PKC alphaRegPhos
Y783RNPGFyVEANPSRCHPRD; RegPhos; SysPTM
Y1003KKFLQyNRLQLPI-PLC-YPhosphoSitePlus

Dephosphorylation site
PLCG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362369P325SCOSMICMelanoma
ENSP00000362369P1223SCOSMICSkin Cancer21984974
ENSP00000362369S489CCOSMICLung Cancer
ENSP00000244007A995PSjoblom2006, COSMICBreast Cancer16959974, 18428421
ENSP00000244007S489CCOSMICLung Cancer
ENSP00000362369A995PSjoblom2006, COSMICBreast Cancer16959974, 18428421
ENSP00000244007S582CCOSMICBreast Cancer
ENSP00000244007P964SCOSMICSkin Cancer21984974
ENSP00000362369P964SCOSMICSkin Cancer21984974
ENSP00000362369V108IDing2008, COSMICLung Cancer18948947
ENSP00000244007V108IDing2008, COSMICLung Cancer18948947
ENSP00000362369S582CCOSMICBreast Cancer
ENSP00000244007P325SCOSMICMelanoma
ENSP00000244007P1223SCOSMICSkin Cancer21984974

Differential expressed protein
PLCG1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y977PI-PLC-YIGTERACyRDMSSFPcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
TEC_HUMANPLCG1_HUMANkinase -> substrateNetPath
ZAGL2_HUMANPLCG1_HUMANkinase -> substrateRegPhos
SRC_HUMANPLCG1_HUMANkinase -> substrateHPRD; RegPhos
RET_HUMANPLCG1_HUMANkinase -> substrateHPRD; RegPhos
LYN_HUMANPLCG1_HUMANkinase -> substrateRegPhos
PGFRB_HUMANPLCG1_HUMANkinase -> substrateRegPhos
KPCD1_HUMANPLCG1_HUMANkinase -> substrateHPRD; NetPath
FGFR1_HUMANPLCG1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
TYRO3_HUMANPLCG1_HUMANkinase -> substrateRobert H Newman (2013)
ITK_HUMANPLCG1_HUMANkinase -> substrateNetPath
NCK1_HUMANPLCG1_HUMANkinase -> substrateKEGG
KSYK_HUMANPLCG1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
PKD1_HUMANPLCG1_HUMANkinase -> substrateRegPhos
HCK_HUMANPLCG1_HUMANkinase -> substrateRegPhos
BTK_HUMANPLCG1_HUMANkinase -> substrateKEGG; NetPath
KPCA_HUMANPLCG1_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANPLCG1_HUMANkinase -> substrateRegPhos
PTPRJ_HUMANPLCG1_HUMANphosphatase -> substrateNetPath
PLCG1_HUMANKPCA_HUMANenzyme catalysisKEGG
PI3R5_HUMANPLCG1_HUMANenzyme catalysisKEGG
PLCG1_HUMANKPCT_HUMANotherKEGG
PLCG1_HUMANCHP1_HUMANotherKEGG
PLCG1_HUMANGRP1_HUMANotherKEGG
VGFR2_HUMANPLCG1_HUMANotherKEGG
PLCG1_HUMANPA24B_HUMANotherKEGG
EGFR_HUMANPLCG1_HUMANotherKEGG
PLCG1_HUMANKPCA_HUMANotherKEGG
PLCG1_HUMANKCC2A_HUMANotherKEGG
PLCG1_HUMANNOS3_HUMANotherKEGG
LCP2_HUMANPLCG1_HUMANotherKEGG
PLCG1_HUMANITPR1_HUMANotherKEGG
KCC4_HUMANPLCG1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04064NF-kappa B signaling pathway
hsa05169Epstein-Barr virus infection
hsa04370VEGF signaling pathway
hsa05110Vibrio cholerae infection
hsa05223Non-small cell lung cancer
hsa04670Leukocyte transendothelial migration
hsa04070Phosphatidylinositol signaling system
hsa04650Natural killer cell mediated cytotoxicity
hsa04666Fc gamma R-mediated phagocytosis
hsa01100Metabolic pathways
hsa04012ErbB signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa00562Inositol phosphate metabolism
hsa04020Calcium signaling pathway
hsa05214Glioma
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIDAcellular_component
GO:0007165signal transductionNASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030971receptor tyrosine kinase bindingIEAmolecular_function
GO:0001726ruffleIDAcellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0010634positive regulation of epithelial cell migrationIMPbiological_process
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0071364cellular response to epidermal growth factor stimuIDAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0008180signalosomeIDAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005168neurotrophin TRKA receptor bindingIPImolecular_function
GO:0000186activation of MAPKK activityTASbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0004435phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005057receptor signaling protein activityNASmolecular_function
GO:0004629phospholipase C activityTASmolecular_function
GO:0035254glutamate receptor bindingIEAmolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0043536positive regulation of blood vessel endothelial ceIDAbiological_process
GO:0009395phospholipid catabolic processIEAbiological_process


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