| UniProt/SwissProt ID: | SIK2_HUMAN |
| Description: | salt-inducible kinase 2 [Source:HGNC Symbol;Acc:21680] |
| Location: | chr11 q23.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S590 | RASDTsLTQGI | PhosphoSitePlus | |
| S379 | PVTMHsPNMRL | PhosphoSitePlus | |
| S534 | LEDNPsLKDIM | PhosphoSitePlus | |
| S90 | VMETKsMLYLV | Pkinase_CAMK | PhosphoSitePlus |
| Y283 | QRPVLyPQEQE | PhosphoSitePlus | |
| T359 | QRRPStIAEQT | PhosphoSitePlus | |
| T175 | GELLAtWCGSP | LKB1 | phosphoELM |
| S343 | KSHRSsFPVEQ | PhosphoSitePlus | |
| T484 | GQRRHtLSEVT | PhosphoSitePlus | |
| S587 | EGRRAsDTSLT | PhosphoSitePlus; HPRD; phosphoELM | |
| Y65 | NLEKIyREVQI | Pkinase_CAMK | PhosphoSitePlus |
| S512 | SPSLDsVDSEY | PhosphoSitePlus | |
| T589 | RRASDtSLTQG | PhosphoSitePlus | |
| S486 | RRHTLsEVTNQ | PhosphoSitePlus | |
| S358 | RQRRPsTIAEQ | PhosphoSitePlus | |
| T25 | YDIEGtLGKGN | Pkinase_CAMK | PhosphoSitePlus |
| S576 | EVHNRsPVSFR | PhosphoSitePlus | |
| Y700 | NTCQLyCKEPP | PhosphoSitePlus | |
| T175 | GELLAtWCGSP | Pkinase_CAMK | PhosphoSitePlus |
| Dephosphorylation site |
| SIK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000305976 | A635V | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000305976 | G497E | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
| Differential expressed protein |
| SIK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SIK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SIK2_HUMAN | IRS1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| SIK2_HUMAN | CRTC2_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | SIK2_HUMAN | kinase -> substrate | RegPhos |
| STK11_HUMAN | SIK2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SIK2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0046626 | regulation of insulin receptor signaling pathway | ISS | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | ISS | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008286 | insulin receptor signaling pathway | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |