Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SIK2_HUMAN
Description:salt-inducible kinase 2 [Source:HGNC Symbol;Acc:21680]
Location:chr11 q23.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S590RASDTsLTQGIPhosphoSitePlus
S379PVTMHsPNMRLPhosphoSitePlus
S534LEDNPsLKDIMPhosphoSitePlus
S90VMETKsMLYLVPkinase_CAMKPhosphoSitePlus
Y283QRPVLyPQEQEPhosphoSitePlus
T359QRRPStIAEQTPhosphoSitePlus
T175GELLAtWCGSPLKB1phosphoELM
S343KSHRSsFPVEQPhosphoSitePlus
T484GQRRHtLSEVTPhosphoSitePlus
S587EGRRAsDTSLTPhosphoSitePlus; HPRD; phosphoELM
Y65NLEKIyREVQIPkinase_CAMKPhosphoSitePlus
S512SPSLDsVDSEYPhosphoSitePlus
T589RRASDtSLTQGPhosphoSitePlus
S486RRHTLsEVTNQPhosphoSitePlus
S358RQRRPsTIAEQPhosphoSitePlus
T25YDIEGtLGKGNPkinase_CAMKPhosphoSitePlus
S576EVHNRsPVSFRPhosphoSitePlus
Y700NTCQLyCKEPPPhosphoSitePlus
T175GELLAtWCGSPPkinase_CAMKPhosphoSitePlus

Dephosphorylation site
SIK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305976A635VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000305976G497ETCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
SIK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SIK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SIK2_HUMANIRS1_HUMANkinase -> substrateHPRD; RegPhos
SIK2_HUMANCRTC2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANSIK2_HUMANkinase -> substrateRegPhos
STK11_HUMANSIK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
SIK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0046626regulation of insulin receptor signaling pathwayISSbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0005737cytoplasmISScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process


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