Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EGR2_HUMAN
Description:early growth response 2 [Source:HGNC Symbol;Acc:3239]
Location:chr10 q21.3
Node attribute:TF; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T391TTHIRtHTGEKzf-C2H2PhosphoSitePlus
T393HIRTHtGEKPFPhosphoSitePlus
S70TGEKRsLDLPYPhosphoSitePlus

Dephosphorylation site
EGR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000242480G284VCOSMICHead and Neck Cancer21798893
ENSP00000242480G45RCOSMICOvarian Cancer21720365

Differential expressed protein
EGR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EGR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EGR2_HUMANMDR1_HUMANTF -> target geneTRANSFAC
ELK1_HUMANEGR2_HUMANTF -> target geneTRANSFAC
SRF_HUMANEGR2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
EGR2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0035284brain segmentationIEAbiological_process
GO:0048168regulation of neuronal synaptic plasticityIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0044212transcription regulatory region DNA bindingISSmolecular_function
GO:0008045motor neuron axon guidanceIEAbiological_process
GO:0021569rhombomere 3 developmentIEAbiological_process
GO:0016925protein sumoylationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0030278regulation of ossificationIEAbiological_process
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0007622rhythmic behaviorIEAbiological_process
GO:0006611protein export from nucleusISSbiological_process
GO:0001102RNA polymerase II activating transcription factor ISSmolecular_function
GO:0001102RNA polymerase II activating transcription factor IEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007420brain developmentTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0021612facial nerve structural organizationIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0007422peripheral nervous system developmentTASbiological_process
GO:0006366transcription from RNA polymerase II promoterISSbiological_process
GO:0045444fat cell differentiationISSbiological_process
GO:0014037Schwann cell differentiationIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0006611protein export from nucleusIEAbiological_process
GO:0021660rhombomere 3 formationIEAbiological_process
GO:0003682chromatin bindingISSmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0042552myelinationIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0016874ligase activityIEAmolecular_function
GO:0021666rhombomere 5 formationIEAbiological_process


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