Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRF3_HUMAN
Description:interferon regulatory factor 3 [Source:HGNC Symbol;Acc:6118]
Location:chr19 q13.33
Node attribute:PPI(source); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T404HPLSLtSDQYKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S175PLRSPsLDNPTPhosphoSitePlus; HPRD
S386VGGASsLENTVIKK_epsilonphosphoELM
S402NSHPLsLTSDQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S385RVGGAsSLENTIKKe(IKK epsilonRegPhos
S386VGGASsLENTVIKK_groupRegPhos
S398LHISNsHPLSLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S386VGGASsLENTVTBK1phosphoELM
S173PQPLRsPSLDNPhosphoSitePlus
T135GSTSDtQEDILPhosphoSitePlus
S396VDLHIsNSHPLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T390SSLENtVDLHIPhosphoSitePlus
S339EGSGRsPRYALIRF-3PhosphoSitePlus
S386VGGASsLENTVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S405PLSLTsDQYKAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S385RVGGAsSLENTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T370VKVVPtCLRALIRF-3PhosphoSitePlus
S14LPWLVsQLDLGIRFPhosphoSitePlus
S385RVGGAsSLENTTBK1phosphoELM; RegPhos

Dephosphorylation site
IRF3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000310127E137KCOSMICOvarian Cancer21720365
ENSP00000310127P103SCOSMICOvarian Cancer21720365

Differential expressed protein
IRF3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRF3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WEE1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
PRKY_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
ARAF_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANIRF3_HUMANkinase -> substrateRegPhos
TYK2_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
STK40_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANIRF3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCZ_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
IRF3_HUMANCXCL9_HUMANotherKEGG
IRF3_HUMANCXL11_HUMANTF -> target geneKEGG
IRF3_HUMANTNR5_HUMANTF -> target geneKEGG
IRF3_HUMANIFNB_HUMANTF -> target geneKEGG
IRF3_HUMANCD80_HUMANTF -> target geneKEGG
IRF3_HUMANCXL10_HUMANTF -> target geneKEGG
IRF3_HUMANCD86_HUMANTF -> target geneKEGG
IRF3_HUMANIFNB_HUMANTF -> target geneTRANSFAC
IRF3_HUMANISG15_HUMANTF -> target geneTRANSFAC
IRF3_HUMANIFNA1_HUMANTF -> target geneTRANSFAC
IRF3_HUMANCCL5_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa05169Epstein-Barr virus infection
hsa05168Herpes simplex infection
hsa05160Hepatitis C
hsa04623Cytosolic DNA-sensing pathway
hsa04620Toll-like receptor signaling pathway
hsa05162Measles
hsa05164Influenza A
hsa04622RIG-I-like receptor signaling pathway
hsa05133Pertussis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0071888macrophage apoptotic processTASbiological_process
GO:0006974response to DNA damage stimulusTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0000975regulatory region DNA bindingIEAmolecular_function
GO:0006917induction of apoptosisTASbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0003712transcription cofactor activityTASmolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0032728positive regulation of interferon-beta productionISSbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0032727positive regulation of interferon-alpha productionISSbiological_process
GO:0051607defense response to virusISSbiological_process
GO:0039530MDA-5 signaling pathwayTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045087innate immune responseTASbiological_process


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