Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMAD3_HUMAN
Description:SMAD family member 3 [Source:HGNC Symbol;Acc:6769]
Location:chr15 q22.33
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S204SMDAGsPNLSPErk2(MAPK1RegPhos
S213SPNPMsPAHNNMAPK1HPRD; phosphoELM
T179SNIPEtPPPGYCDK4HPRD; phosphoELM; RegPhos
T179SNIPEtPPPGYCDK2HPRD; phosphoELM; RegPhos
S418QMGSPsIRCSSPhosphoSitePlus
S208GSPNLsPNPMSMAPK1HPRD; phosphoELM
Y125VCVNPyHYQRVMH1PhosphoSitePlus
T132YQRVEtPVLPPPhosphoSitePlus
T179SNIPEtPPPGYPhosphoSitePlus; phosphoELM
S423SIRCSsMAP3K7HPRD
S208GSPNLsPNPMSCDK2HPRD; RegPhos
S208GSPNLsPNPMSCDK4HPRD; RegPhos
S416LTQMGsPSIRCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S423SIRCSsVS___PhosphoSitePlus
S422PSIRCsSMAP3K7HPRD
S422PSIRCsSphosphoELM
S208GSPNLsPNPMSErk2(MAPK1RegPhos
S78GRLQVsHRKGLMH1PhosphoSitePlus
S422PSIRCsSVSRegPhos
S425RCSSVsTAK1RegPhos
S423SIRCSsVSTAK1RegPhos
S204SMDAGsPNLSPPhosphoSitePlus; phosphoELM
Y88LPHVIyCRLWRMH1PhosphoSitePlus
T179SNIPEtPPPGYMAPK1HPRD; phosphoELM
T388EYRRQtVTSTPMH2PhosphoSitePlus
S208GSPNLsPNPMSErk2RegPhos
S423SIRCSsVSRegPhos
S423SIRCSsphosphoELM
T8SILPFtPPIVKCDK4HPRD; phosphoELM; RegPhos
T8SILPFtPPIVKCDK2HPRD; phosphoELM; RegPhos
S208GSPNLsPNPMSMAPK14HPRD
S425RCSSphosphoELM
S208GSPNLsPNPMSp38aRegPhos
S422PSIRCsSVS__PhosphoSitePlus
T179SNIPEtPPPGYErk2RegPhos
T8SILPFtPPIVKPhosphoSitePlus; phosphoELM
S213SPNPMsPAHNNCDK2HPRD; phosphoELM; RegPhos
S204SMDAGsPNLSPMAPK1HPRD; phosphoELM
S208GSPNLsPNPMSPhosphoSitePlus; phosphoELM
S422PSIRCsSVSTAK1RegPhos
S213SPNPMsPAHNNPhosphoSitePlus; phosphoELM
S425RCSSMAP3K7HPRD
S309FAECLsDSAIFMH2PhosphoSitePlus
S425RCSSVs_____PhosphoSitePlus
S425RCSSVsRegPhos
S204SMDAGsPNLSPErk2RegPhos
S204SMDAGsPNLSPCDK4HPRD; RegPhos
S204SMDAGsPNLSPCDK2HPRD; RegPhos
S213SPNPMsPAHNNErk2RegPhos
S213SPNPMsPAHNNCDK4HPRD; phosphoELM; RegPhos
S213SPNPMsPAHNNMAPK14HPRD
S213SPNPMsPAHNNp38aRegPhos

Dephosphorylation site
SMAD3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000332973V294MBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000332973S422FCOSMICPancreatic Cancer
ENSP00000441856S422FCOSMICPancreatic Cancer
ENSP00000332973P393LSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000332973S425CCOSMICHead and Neck Cancer21798897
ENSP00000332973S423GCOSMICOvarian Cancer20826764
ENSP00000441856S425CCOSMICHead and Neck Cancer21798897
ENSP00000441856S423GCOSMICOvarian Cancer20826764
ENSP00000332973P393LHPIColorectal Cancer16959974
ENSP00000332973S317FBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000441856P393LCOSMICIntestines Cancer16959974

Differential expressed protein
SMAD3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMAD3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANSMAD3_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PKN1_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSMAD3_HUMANkinase -> substrateRegPhos
AKT1_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANSMAD3_HUMANkinase -> substrateHPRD
KS6A2_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
PRKY_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
KCC1D_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANSMAD3_HUMANkinase -> substrateHPRD
CDK18_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
NR2C2_HUMANSMAD3_HUMANkinase -> substrateRegPhos
CDK4_HUMANSMAD3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK5_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANSMAD3_HUMANkinase -> substrateRegPhos
ACVR1_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)
SMAD3_HUMANPAI1_HUMANTF -> target geneTRANSFAC
SMAD3_HUMANCO1A2_HUMANTF -> target geneTRANSFAC
SMAD3_HUMANPTHR_HUMANTF -> target geneTRANSFAC
SMAD3_HUMANMMP1_HUMANTF -> target geneTRANSFAC
SMAD3_HUMANCO7A1_HUMANTF -> target geneTRANSFAC
SMAD3_HUMANJUN_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05142Chagas disease (American trypanosomiasis)
hsa04144Endocytosis
hsa04310Wnt signaling pathway
hsa05166HTLV-I infection
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa04520Adherens junction
hsa04350TGF-beta signaling pathway
hsa05220Chronic myeloid leukemia
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001102RNA polymerase II activating transcription factor IPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0071141SMAD protein complexIDAcellular_component
GO:0046332SMAD bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0019049evasion or tolerance of host defenses by virusIDAbiological_process
GO:0048340paraxial mesoderm morphogenesisIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0050927positive regulation of positive chemotaxisIEAbiological_process
GO:0007369gastrulationIEAbiological_process
GO:0045930negative regulation of mitotic cell cycleIMPbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0006810transportIDAbiological_process
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0048589developmental growthIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0007492endoderm developmentIEAbiological_process
GO:0042177negative regulation of protein catabolic processIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032924activin receptor signaling pathwayIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIMPbiological_process
GO:0030618transforming growth factor beta receptor, pathway-IDAmolecular_function
GO:0038092nodal signaling pathwayIMPbiological_process
GO:0070410co-SMAD bindingIPImolecular_function
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0005160transforming growth factor beta receptor bindingIPImolecular_function
GO:0000988protein binding transcription factor activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0070412R-SMAD bindingIPImolecular_function
GO:0002520immune system developmentIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0001666response to hypoxiaIMPbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0032909regulation of transforming growth factor beta2 proIMPbiological_process
GO:0031053primary miRNA processingTASbiological_process
GO:0070306lens fiber cell differentiationIEAbiological_process
GO:0001836release of cytochrome c from mitochondriaIEAbiological_process
GO:0030501positive regulation of bone mineralizationIEAbiological_process
GO:0010694positive regulation of alkaline phosphatase activiIEAbiological_process
GO:0001933negative regulation of protein phosphorylationIMPbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0035413positive regulation of catenin import into nucleusIMPbiological_process
GO:0008637apoptotic mitochondrial changesIEAbiological_process
GO:0043130ubiquitin bindingIDAmolecular_function
GO:0042060wound healingTASbiological_process
GO:0050821protein stabilizationIMPbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0017015regulation of transforming growth factor beta receIEAbiological_process
GO:0006917induction of apoptosisIMPbiological_process
GO:0032731positive regulation of interleukin-1 beta productiIEAbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0043235receptor complexIMPcellular_component
GO:0007183SMAD protein complex assemblyIEAbiological_process
GO:0061045negative regulation of wound healingIEAbiological_process
GO:0045216cell-cell junction organizationIMPbiological_process
GO:0005518collagen bindingIEAmolecular_function
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0007050cell cycle arrestIMPbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0060290transdifferentiationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0050776regulation of immune responseIEAbiological_process
GO:1901313positive regulation of gene expression involved inIMPbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0032332positive regulation of chondrocyte differentiationIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0060039pericardium developmentIEAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0016202regulation of striated muscle tissue developmentIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0009880embryonic pattern specificationIEAbiological_process
GO:0051894positive regulation of focal adhesion assemblyIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0042993positive regulation of transcription factor importIDAbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0001756somitogenesisIEAbiological_process
GO:0006955immune responseIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0000987core promoter proximal region sequence-specific DNIDAmolecular_function
GO:0048617embryonic foregut morphogenesisIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0043234protein complexIEAcellular_component
GO:0019902phosphatase bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0051496positive regulation of stress fiber assemblyIEAbiological_process
GO:0032916positive regulation of transforming growth factor IEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0030878thyroid gland developmentIEAbiological_process
GO:0002076osteoblast developmentIEAbiological_process
GO:0005637nuclear inner membraneIDAcellular_component
GO:0010718positive regulation of epithelial to mesenchymal tIMPbiological_process
GO:0033689negative regulation of osteoblast proliferationIEAbiological_process
GO:0051098regulation of bindingIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIMPbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function