Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AAPK2_HUMAN
Description:protein kinase, AMP-activated, alpha 2 catalytic subunit [Source:HGNC Symbol;Acc:9377]
Location:chr1 p32.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T524SLTGStLSSVSPhosphoSitePlus
T172GEFLRtSCGSPAMPK_groupphosphoELM; RegPhos
T521LTGSLtGSTLSPhosphoSitePlus
S176RTSCGsPNYAAPkinasePhosphoSitePlus; SysPTM
S377PLIADsPKARCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S173EFLRTsCGSPNphosphoELM; RegPhos
S173EFLRTsCGSPNPkinasePhosphoSitePlus
S501HRPRSsFDSTTPhosphoSitePlus
S161ADFGLsNMMSDPkinasePhosphoSitePlus
S483EQRSGsSTPQRPhosphoSitePlus
S509STTAEsHSLSGPhosphoSitePlus
T172GEFLRtSCGSPPkinasePhosphoSitePlus
T172GEFLRtSCGSPLKB1(STK11) RegPhos
S534SPRLGsHTMDFPhosphoSitePlus
S500LHRPRsSFDSTPhosphoSitePlus; HPRD; RegPhos
S176RTSCGsPNYAAHPRD; phosphoELM; SysPTM
S491PQRSCsAAGLHPhosphoSitePlus
S511TAESHsLSGSLPhosphoSitePlus
S527GSTLSsVSPRLPhosphoSitePlus
Y232RGGVFyIPEYLPkinasePhosphoSitePlus
Y324QLAVAyHLIIDPhosphoSitePlus; HPRD
S165LSNMMsDGEFLPkinasePhosphoSitePlus
Y179CGSPNyAAPEVPkinasePhosphoSitePlus
T172GEFLRtSCGSPHPRD; RegPhos

Dephosphorylation site
AAPK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360290T506ATCGAOvarian Cancer21720365, 18772890
ENSP00000360290R407QGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000360290H73QCOSMICOvarian Cancer21720365
ENSP00000360290S355TCOSMICLung Cancer20668451
ENSP00000360290T506ACOSMICOvarian Cancer21720365
ENSP00000360290R239CCOSMICMelanoma21499247
ENSP00000360290A417DCOSMICHead and Neck Cancer21798893
ENSP00000360290P371TSjoblom2006, COSMIC, HPI, Greenman2007Breast Cancer15908952, 16959974, 17344846, 18428421, 16959974, 17344846, 16959974 17344846
ENSP00000360290S523GSjoblom2006, HPI, BIOMARTBreast Cancer15908952, 16959974, 18428421, 21930507, 21930502
ENSP00000360290D461NCOSMICLung Cancer20668451
ENSP00000360290D271YBIOMARTBreast Cancer21930507, 21930502
ENSP00000360290D503HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
AAPK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AAPK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAPK2_HUMANAAPK1_HUMANkinase -> substrateRegPhos
AAPK2_HUMANACACA_HUMANkinase -> substrateRegPhos
AAPK2_HUMANEP300_HUMANkinase -> substrateRegPhos
AAPK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANRAF1_HUMANkinase -> substrateRegPhos
AAPK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANZMYM3_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANSPN1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
STK11_HUMANAAPK2_HUMANkinase -> substrateRegPhos
AAPK2_HUMANNOS3_HUMANkinase -> substrateRegPhos
AAPK2_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANARI3A_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANEF1D_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANAAPK2_HUMANkinase -> substrateRegPhos
AAPK2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANNOL7_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANTBX20_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANCSN6_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANACACB_HUMANkinase -> substrateHPRD; RegPhos
AAPK2_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANLIPS_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANAAPK2_HUMANkinase -> substrateRegPhos
AAPK2_HUMANLUZP1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANF262_HUMANkinase -> substrateHPRD; RegPhos
AAPK2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANCASP6_HUMANkinase -> substrateRegPhos
AAPK2_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANEF2K_HUMANkinase -> substrateRegPhos
AAPK2_HUMANHNF4A_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04140Regulation of autophagy
hsa04920Adipocytokine signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035404histone-serine phosphorylationIEAbiological_process
GO:0032007negative regulation of TOR signaling cascadeIEAbiological_process
GO:0042304regulation of fatty acid biosynthetic processTASbiological_process
GO:0050405[acetyl-CoA carboxylase] kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityISSmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process
GO:0042752regulation of circadian rhythmISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0008610lipid biosynthetic processISSbiological_process
GO:0047322[hydroxymethylglutaryl-CoA reductase (NADPH)] kinaIEAmolecular_function
GO:0046320regulation of fatty acid oxidationTASbiological_process
GO:0010508positive regulation of autophagyISSbiological_process
GO:0031669cellular response to nutrient levelsISSbiological_process
GO:0006914autophagyIEAbiological_process
GO:0035174histone serine kinase activityISSmolecular_function
GO:0005829cytosolTAScellular_component
GO:2000505regulation of energy homeostasisISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0042149cellular response to glucose starvationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0006633fatty acid biosynthetic processIEAbiological_process
GO:0042593glucose homeostasisISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0007050cell cycle arrestTASbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0045821positive regulation of glycolysisISSbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0006853carnitine shuttleTASbiological_process
GO:0008610lipid biosynthetic processIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004679AMP-activated protein kinase activityIDAmolecular_function
GO:0003682chromatin bindingISSmolecular_function
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0042752regulation of circadian rhythmIEAbiological_process
GO:0042149cellular response to glucose starvationISSbiological_process
GO:0048511rhythmic processIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0031669cellular response to nutrient levelsIEAbiological_process
GO:0006950response to stressISSbiological_process
GO:0032007negative regulation of TOR signaling cascadeISSbiological_process
GO:0006695cholesterol biosynthetic processIEAbiological_process
GO:0035174histone serine kinase activityIEAmolecular_function
GO:0010508positive regulation of autophagyIEAbiological_process
GO:0055089fatty acid homeostasisISSbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process