Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ESR2_HUMAN
Description:estrogen receptor 2 (ER beta) [Source:HGNC Symbol;Acc:3468]
Location:chr14 q23.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S463LLMLLsHVRHAHormone_recepPhosphoSitePlus
S165HYGVWsCEGCKRSK-1phosphoELM
Y488NVVPVyDLLLERegPhos
S469HVRHAsNKGMEHormone_recepPhosphoSitePlus
S87TPGHLsPLVVHphosphoELM; RegPhos
S105AEPQKsPWCEAphosphoELM; RegPhos
Y56PAVMNySIPSNERbeta_N; Oest_recepPhosphoSitePlus
S105AEPQKsPWCEAERbeta_N; Oest_recepPhosphoSitePlus
S176AFFKRsIQGHNzf-C4PhosphoSitePlus
S200KNRRKsCQACRzf-C4PhosphoSitePlus
S87TPGHLsPLVVHERbeta_N; Oest_recepPhosphoSitePlus
S165HYGVWsCEGCKRSK1RegPhos

Dephosphorylation site
ESR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000343925W80*COSMICCentral Nervous System Neoplasms18772890
ENSP00000343925T271ICOSMICSkin Cancer21984974
ENSP00000343925A287TCOSMICOvarian Cancer21720365
ENSP00000343925S448TCOSMICSkin Cancer21984974
ENSP00000343925D365fs*6COSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
ESR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S105ERbeta_N; Oest_recepLYAEPQKsPWCEARSbreast cancer20696772PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANESR2_HUMANkinase -> substrateRegPhos
KS6A1_HUMANESR2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ESR2_HUMANCO3_HUMANTF -> target geneTRANSFAC
ESR2_HUMANTFF1_HUMANTF -> target geneTRANSFAC
ESR2_HUMANCATD_HUMANTF -> target geneTRANSFAC
ESR2_HUMANNQO1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ESR2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmTAScellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0003707steroid hormone receptor activityTASmolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0048019receptor antagonist activityNASmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0060743epithelial cell maturation involved in prostate glIEAbiological_process
GO:0030308negative regulation of cell growthNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0060068vagina developmentIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0005496steroid bindingTASmolecular_function
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0001046core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0030520intracellular estrogen receptor signaling pathwayIEAbiological_process
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0030520intracellular estrogen receptor signaling pathwayTASbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0030284estrogen receptor activityTASmolecular_function
GO:0060065uterus developmentIEAbiological_process
GO:1900116extracellular negative regulation of signal transdNASbiological_process
GO:0034056estrogen response element bindingIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0060740prostate gland epithelium morphogenesisIEAbiological_process
GO:0005634nucleusTAScellular_component
GO:0005576extracellular regionNAScellular_component
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0004879ligand-activated sequence-specific DNA binding RNANASmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0060766negative regulation of androgen receptor signalingIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0005496steroid bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003713transcription coactivator activityTASmolecular_function