Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MP2K7_HUMAN
Description:mitogen-activated protein kinase kinase 7 [Source:HGNC Symbol;Acc:6847]
Location:chr19 p13.2
Node attribute:PPI(source); substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S271GRLVDsKAKTRMAP3K1phosphoELM; RegPhos
T275DSKAKtRSAGCMAP3K1phosphoELM; RegPhos
S35LNLDIsPQRPRPhosphoSitePlus; HPRD
T401DVMAKtESPRTPhosphoSitePlus
S86LFTPRsMESIEPhosphoSitePlus; HPRD
S89PRSMEsIEIDQPhosphoSitePlus; HPRD
T275DSKAKtRSAGCPkinasePhosphoSitePlus
T142MRFRKtGHVIAPkinasePhosphoSitePlus
T83PSTLFtPRSMEPhosphoSitePlus
S271GRLVDsKAKTRPkinasePhosphoSitePlus
S378KLLEHsFIKRYPkinasePhosphoSitePlus
S277KAKTRsAGCAAPkinasePhosphoSitePlus

Dephosphorylation site
MP2K7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381066R162HHPIColorectal Cancer17344846

Differential expressed protein
MP2K7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MP2K7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MP2K7_HUMANMK09_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
M3K12_HUMANMP2K7_HUMANkinase -> substrateKEGG
MK10_HUMANMP2K7_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
M3K1_HUMANMP2K7_HUMANkinase -> substrateRegPhos
M3K11_HUMANMP2K7_HUMANkinase -> substrateKEGG
MP2K7_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANRO52_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
M3K13_HUMANMP2K7_HUMANkinase -> substrateKEGG; Robert H Newman (2013)
MP2K7_HUMANKAD2_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANMK08_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
MP2K7_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANMP2K7_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
MLTK_HUMANMP2K7_HUMANkinase -> substrateKEGG
RIPK2_HUMANMP2K7_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANEXOS5_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANMK10_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MP2K7_HUMANM3K7_HUMANkinase -> substrateKEGG
MP2K7_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
PPM1A_HUMANMP2K7_HUMANphosphatase -> substrateKEGG
RAC1_HUMANMP2K7_HUMANotherKEGG
MP2K7_HUMANMK08_HUMANotherKEGG
NCK1_HUMANMP2K7_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05164Influenza A
hsa04012ErbB signaling pathway
hsa05169Epstein-Barr virus infection
hsa04620Toll-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa04010MAPK signaling pathway
hsa04380Osteoclast differentiation
hsa04664Fc epsilon RI signaling pathway
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007254JNK cascadeTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005634nucleusISScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007165signal transductionTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007257activation of JUN kinase activityIEAbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0006950response to stressIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0007257activation of JUN kinase activityISSbiological_process
GO:0005737cytoplasmISScellular_component
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0004708MAP kinase kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0004708MAP kinase kinase activityIDAmolecular_function
GO:0031435mitogen-activated protein kinase kinase kinase binIEAmolecular_function
GO:0006950response to stressIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0008545JUN kinase kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0051403stress-activated MAPK cascadeIDAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0019903protein phosphatase bindingISSmolecular_function
GO:0051403stress-activated MAPK cascadeIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function