| UniProt/SwissProt ID: | STAT6_HUMAN |
| Description: | signal transducer and activator of transcription 6, interleukin-4 induced [Source:HGNC Symbol;Acc:11368] |
| Location: | chr12 q13.3 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y641 | KDGRGyVPATI | JAK1 | RegPhos |
| T645 | GYVPAtIKMTV | PhosphoSitePlus; phosphoELM; RegPhos | |
| T525 | GVLDLtKRCLR | STAT_bind | PhosphoSitePlus |
| S707 | PYQGLsPEESV | PhosphoSitePlus | |
| Y641 | KDGRGyVPATI | PhosphoSitePlus; HPRD; RegPhos | |
| S8 | LWGLVsKMPPE | HPRD | |
| S8 | LWGLVsKMPPE | STAT_int | PhosphoSitePlus |
| Y641 | KDGRGyVPATI | JAK_group | phosphoELM; RegPhos |
| S756 | EHAVSsPDPLL | PhosphoSitePlus; phosphoELM; RegPhos | |
| S407 | QLQALsLPLVV | STAT_bind | PhosphoSitePlus |
| Dephosphorylation site |
| STAT6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000451742 | D46N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000401486 | D46N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000401486 | V414L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000438451 | D46N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000438451 | Q71R | COSMIC | Lung Cancer | 18948947 | ENSP00000438451 | V414L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000451742 | V414L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000300134 | Q71R | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000451742 | Q71R | COSMIC | Lung Cancer | 18948947 | ENSP00000300134 | D46N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000300134 | V414L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000401486 | Q71R | COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| STAT6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| STAT6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | STAT6_HUMAN | kinase -> substrate | RegPhos |
| AKT1_HUMAN | STAT6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK1_HUMAN | STAT6_HUMAN | kinase -> substrate | RegPhos; NetPath |
| STAT6_HUMAN | OPRM_HUMAN | TF -> target gene | TRANSFAC |
| STAT6_HUMAN | LOX15_HUMAN | TF -> target gene | TRANSFAC |
| STAT6_HUMAN | IL4RA_HUMAN | TF -> target gene | TRANSFAC |
| STAT6_HUMAN | IGHE_HUMAN | TF -> target gene | TRANSFAC |
| STAT6_HUMAN | IL2RA_HUMAN | TF -> target gene | TRANSFAC |
| STAT6_HUMAN | FCGR1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000979 | RNA polymerase II core promoter sequence-specific | IEA | molecular_function |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0033598 | mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0002829 | negative regulation of type 2 immune response | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0002296 | T-helper 1 cell lineage commitment | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0048295 | positive regulation of isotype switching to IgE is | IEA | biological_process |
| GO:0034097 | response to cytokine stimulus | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0060443 | mammary gland morphogenesis | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000790 | nuclear chromatin | IEA | cellular_component |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |