| UniProt/SwissProt ID: | PKNX1_HUMAN |
| Description: | PBX/knotted 1 homeobox 1 [Source:HGNC Symbol;Acc:9022] |
| Location: | chr21 q22.3 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S239 | IRIQNsQLQLQ | PhosphoSitePlus | |
| S166 | SGEPGsPYSPV | PhosphoSitePlus | |
| S156 | KTKMNsETLLS | PhosphoSitePlus | |
| Dephosphorylation site |
| PKNX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000291547 | V265I | HPI | Colorectal Cancer | 16959974 | ENSP00000291547 | E72K | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000291547 | D433G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000291547 | V265I | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| PKNX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PKNX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | PKNX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | PKNX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK6_HUMAN | PKNX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | PKNX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK4_HUMAN | PKNX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKNX1_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PKNX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0030218 | erythrocyte differentiation | IEA | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | IEA | molecular_function |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030097 | hemopoiesis | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0043010 | camera-type eye development | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0030217 | T cell differentiation | IEA | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |