| UniProt/SwissProt ID: | SIK3_HUMAN |
| Description: | SIK family kinase 3 [Source:HGNC Symbol;Acc:29165] |
| Location: | chr11 q23.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T163 | GQLLKtWCGSP | PhosphoSitePlus | |
| T411 | SMRRHtVGVAD | PhosphoSitePlus | |
| T1159 | LQRHHtIQNSD | PhosphoSitePlus | |
| S916 | LQGLLsPRHSL | PhosphoSitePlus | |
| T163 | GQLLKtWCGSP | LKB1 | phosphoELM |
| S568 | PVRRFsDGAAS | PhosphoSitePlus; HPRD | |
| T13 | YEIDRtIGKGN | HPRD | |
| Y604 | QLQKMyGGQID | PhosphoSitePlus | |
| S493 | LGRRAsDGGAN | PhosphoSitePlus | |
| Y1249 | DILLSyKHPEV | PhosphoSitePlus | |
| Dephosphorylation site |
| SIK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000292055 | A1103V | Sjoblom2006, HPI, BIOMART | Breast Cancer | 16959974, 21930507, 21930502 | ENSP00000292055 | H331L | Sjoblom2006, HPI, BIOMART | Breast Cancer | 16959974, 21930507, 21930502 |
| Differential expressed protein |
| SIK3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SIK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | SIK3_HUMAN | kinase -> substrate | RegPhos |
| SIK3_HUMAN | CRTC2_HUMAN | kinase -> substrate | HPRD |
| STK11_HUMAN | SIK3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SIK3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |