Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SIK3_HUMAN
Description:SIK family kinase 3 [Source:HGNC Symbol;Acc:29165]
Location:chr11 q23.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T163GQLLKtWCGSPPhosphoSitePlus
T411SMRRHtVGVADPhosphoSitePlus
T1159LQRHHtIQNSDPhosphoSitePlus
S916LQGLLsPRHSLPhosphoSitePlus
T163GQLLKtWCGSPLKB1phosphoELM
S568PVRRFsDGAASPhosphoSitePlus; HPRD
T13YEIDRtIGKGNHPRD
Y604QLQKMyGGQIDPhosphoSitePlus
S493LGRRAsDGGANPhosphoSitePlus
Y1249DILLSyKHPEVPhosphoSitePlus

Dephosphorylation site
SIK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000292055A1103VSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000292055H331LSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502

Differential expressed protein
SIK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SIK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSIK3_HUMANkinase -> substrateRegPhos
SIK3_HUMANCRTC2_HUMANkinase -> substrateHPRD
STK11_HUMANSIK3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
SIK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23